Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner.

Autor: Vanhoutte D; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Schips TG; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Minerath RA; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Huo J; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Kavuri NSS; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Prasad V; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Lin SC; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Bround MJ; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Sargent MA; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Adams CM; Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Molkentin JD; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: jeff.molkentin@cchmc.org.

Publikováno v: Cell reports [Cell Rep] 2024 May 28; Vol. 43 (5), pp. 114149. Date of Electronic Publication: 2024 Apr 26.

MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle.

Autor: Huo J; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA., Prasad V; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA., Grimes KM; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA., Vanhoutte D; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA., Blair NS; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA., Lin SC; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA., Bround MJ; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA., Bers DM; Department of Pharmacology, University of California, Davis, Davis, CA 95616, USA., Molkentin JD; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA. Electronic address: jeff.molkentin@cchmc.org.

Publikováno v: Cell reports [Cell Rep] 2023 Nov 28; Vol. 42 (11), pp. 113465. Date of Electronic Publication: 2023 Nov 16.

MCUb Induction Protects the Heart From Postischemic Remodeling.

Autor: Huo J; From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (J.H., M.J.B., K.M.G., M.A.S., J.D.M.)., Lu S; Department of Pharmacology, University of California, Davis (S.L., D.M.B.)., Kwong JQ; Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA (J.Q.K.)., Bround MJ; From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (J.H., M.J.B., K.M.G., M.A.S., J.D.M.)., Grimes KM; From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (J.H., M.J.B., K.M.G., M.A.S., J.D.M.)., Sargent MA; From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (J.H., M.J.B., K.M.G., M.A.S., J.D.M.)., Brown ME; Wallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, GA (M.E.B., M.E.D.)., Davis ME; Wallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, GA (M.E.B., M.E.D.)., Bers DM; Department of Pharmacology, University of California, Davis (S.L., D.M.B.)., Molkentin JD; From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (J.H., M.J.B., K.M.G., M.A.S., J.D.M.).; Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, OH (J.D.M.).

Publikováno v: Circulation research [Circ Res] 2020 Jul 17; Vol. 127 (3), pp. 379-390. Date of Electronic Publication: 2020 Apr 17.

A novel class of cardioprotective small-molecule PTP inhibitors.

Autor: Antonucci S; Department of Biomedical Sciences, University of Padova, Padova, Italy., Di Sante M; Department of Biomedical Sciences, University of Padova, Padova, Italy., Sileikyte J; Vollum Institute, and Department of Physiology and Pharmacology, Portland, OR, USA., Deveraux J; Vollum Institute, and Department of Physiology and Pharmacology, Portland, OR, USA., Bauer T; Systems Biology Center, NHLBI, NIH, Bethesda, MD, USA., Bround MJ; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA., Menabò R; Department of Biomedical Sciences, University of Padova, Padova, Italy; National Research Council of Italy (CNR), Padova, Italy., Paillard M; CarMeN Laboratory, University Claude Bernard Lyon 1, INSA Lyon, Oullins, France., Alanova P; Department of Biomedical Sciences, University of Padova, Padova, Italy; Department of Developmental Cardiology, Institute of Physiology CAS, Prague, Czech Republic., Carraro M; Department of Biomedical Sciences, University of Padova, Padova, Italy., Ovize M; CarMeN Laboratory, University Claude Bernard Lyon 1, INSA Lyon, Oullins, France., Molkentin JD; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA; Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Cohen M; Vollum Institute, and Department of Physiology and Pharmacology, Portland, OR, USA., Forte MA; Vollum Institute, and Department of Physiology and Pharmacology, Portland, OR, USA., Bernardi P; Department of Biomedical Sciences, University of Padova, Padova, Italy; National Research Council of Italy (CNR), Padova, Italy., Di Lisa F; Department of Biomedical Sciences, University of Padova, Padova, Italy; National Research Council of Italy (CNR), Padova, Italy. Electronic address: dilisa@bio.unipd.it., Murphy E; Systems Biology Center, NHLBI, NIH, Bethesda, MD, USA. Electronic address: murphy1@nhlbi.nih.gov.

Publikováno v: Pharmacological research [Pharmacol Res] 2020 Jan; Vol. 151, pp. 104548. Date of Electronic Publication: 2019 Nov 20.

The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle.

Autor: Kwong JQ; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.; Department of Pediatrics, Division of Cardiovascular Biology, Emory University School of Medicine, Atlanta, Georgia, USA., Huo J; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Bround MJ; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Boyer JG; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Schwanekamp JA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Ghazal N; Department of Pediatrics, Division of Cardiovascular Biology, Emory University School of Medicine, Atlanta, Georgia, USA., Maxwell JT; Department of Pediatrics, Division of Cardiovascular Biology, Emory University School of Medicine, Atlanta, Georgia, USA., Jang YC; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA., Khuchua Z; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.; Sechenov University, Moscow, Russia., Shi K; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Bers DM; Department of Pharmacology, University of California, Davis, California, USA., Davis J; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Molkentin JD; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.; Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Publikováno v: JCI insight [JCI Insight] 2018 Nov 15; Vol. 3 (22). Date of Electronic Publication: 2018 Nov 15.