Zobrazeno 1 - 10
of 253
pro vyhledávání: '"MITSUOMI HIRASHIMA"'
Autor:
Laia Querol Cano, Oya Tagit, Yusuf Dolen, Anne van Duffelen, Shannon Dieltjes, Sonja I. Buschow, Toshiro Niki, Mitsuomi Hirashima, Ben Joosten, Koen van den Dries, Alessandra Cambi, Carl G. Figdor, Annemiek B. van Spriel
Publikováno v:
iScience, Vol 22, Iss , Pp 240-255 (2019)
Summary: Endogenous extracellular Galectins constitute a novel mechanism of membrane protein organization at the cell surface. Although Galectins are also highly expressed intracellularly, their cytosolic functions are poorly understood. Here, we inv
Externí odkaz:
https://doaj.org/article/6745288dbb9f4c4897d631f4b7fb6703
Autor:
Toshiro Niki, Koji Fujita, Hugo Rosen, Mitsuomi Hirashima, Tsutomu Masaki, Toshio Hattori, Katsuaki Hoshino
Publikováno v:
Cellular Physiology and Biochemistry, Vol 50, Iss 5, Pp 1856-1868 (2018)
Background/Aims: Galectin-9 is a soluble immune modulator with versatile functions, including a role as an immune checkpoint molecule. Therefore, the amount of galectin-9 in the blood may reflect an individual’s immunological balance. Many studies
Externí odkaz:
https://doaj.org/article/88ccacaf700a4665ae0a0f99f66fc4b5
Autor:
Claire Lhuillier, Clément Barjon, Valentin Baloche, Toshiro Niki, Aurore Gelin, Rami Mustapha, Laetitia Claër, Sylviane Hoos, Yoichi Chiba, Masaki Ueno, Mitsuomi Hirashima, Ming Wei, Olivier Morales, Bertrand Raynal, Nadira Delhem, Olivier Dellis, Pierre Busson
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0202512 (2018)
Extra-cellular galectin-9 (gal-9) is an immuno-modulatory protein with predominant immunosuppressive effects. Inappropriate production of gal-9 has been reported in several human malignancies and viral diseases like nasopharyngeal, pancreatic and ren
Externí odkaz:
https://doaj.org/article/be03e2d39ec746f28578ce32f3a9e63a
Autor:
Yuko Horio, Hidenori Ichiyasu, Keisuke Kojima, Naoki Saita, Yohei Migiyama, Toyohisa Iriki, Kazuhiko Fujii, Toshiro Niki, Mitsuomi Hirashima, Hirotsugu Kohrogi
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180742 (2017)
Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and pulmonary emphysema. Persistent inflammation and remodeling of the lungs and airways result in reduced lung function and a lower quality of life. Ga
Externí odkaz:
https://doaj.org/article/45ffe8f6bebf433f880c22e1b485cca1
Autor:
Taiga Chiyo, Koji Fujita, Hisakazu Iwama, Shintaro Fujihara, Tomoko Tadokoro, Kyoko Ohura, Takanori Matsui, Yasuhiro Goda, Nobuya Kobayashi, Noriko Nishiyama, Tatsuo Yachida, Asahiro Morishita, Hideki Kobara, Hirohito Mori, Toshiro Niki, Mitsuomi Hirashima, Takashi Himoto, Tsutomu Masaki
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2634 (2019)
Galectin-9 (Gal-9) enhances tumor immunity mediated by T cells, macrophages, and dendritic cells. Its expression level in various cancers correlates with prognosis. Furthermore, Gal-9 directly induces apoptosis in various cancers; however, its mechan
Externí odkaz:
https://doaj.org/article/5ac950014df34c469602f2370e1fa7e7
Autor:
Mohamed Abdel-Mohsen, Leonard Chavez, Ravi Tandon, Glen M Chew, Xutao Deng, Ali Danesh, Sheila Keating, Marion Lanteri, Michael L Samuels, Rebecca Hoh, Jonah B Sacha, Philip J Norris, Toshiro Niki, Cecilia M Shikuma, Mitsuomi Hirashima, Steven G Deeks, Lishomwa C Ndhlovu, Satish K Pillai
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005677 (2016)
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (A
Externí odkaz:
https://doaj.org/article/99df66f3b2f4407eb323bcc5b84708fd
Autor:
Koji Fujita, Hisakazu Iwama, Kyoko Oura, Tomoko Tadokoro, Eri Samukawa, Teppei Sakamoto, Takako Nomura, Joji Tani, Hirohito Yoneyama, Asahiro Morishita, Takashi Himoto, Mitsuomi Hirashima, Tsutomu Masaki
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 1, p 74 (2017)
Dysregulation of apoptosis is a major hallmark in cancer biology that might equip tumors with a higher malignant potential and chemoresistance. The anti-cancer activities of lectin, defined as a carbohydrate-binding protein that is not an enzyme or a
Externí odkaz:
https://doaj.org/article/96d63aa9ee8f44aab3bef95210a149ef
Autor:
Reiji Kojima, Tatsukuni Ohno, Motoyasu Iikura, Toshiro Niki, Mitsuomi Hirashima, Keichi Iwaya, Hitoshi Tsuda, Shigeaki Nonoyama, Akio Matsuda, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86106 (2014)
Galectin-9 (Gal-9), a lectin having a β-galactoside-binding domain, can induce apoptosis of Th1 cells by binding to TIM-3. In addition, Gal-9 inhibits IgE/Ag-mediated degranulation of mast cell/basophilic cell lines by binding to IgE, thus blocking
Externí odkaz:
https://doaj.org/article/2e08c6e91f53490aa0974e16fd19a436
Autor:
Masahiro Moritoki, Takeshi Kadowaki, Toshiro Niki, Daisuke Nakano, Genichiro Soma, Hirohito Mori, Hideki Kobara, Tsutomu Masaki, Masakazu Kohno, Mitsuomi Hirashima
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60807 (2013)
Galectin-9 ameliorates various murine autoimmune disease models by regulating T cells and macrophages, although it is not known what role it may have in B cells. The present experiment shows that galectin-9 ameliorates a variety of clinical symptoms,
Externí odkaz:
https://doaj.org/article/d5298e4a49ce4cf18331804bad226c09
Autor:
Marloes J M Gooden, Valerie R Wiersma, Douwe F Samplonius, Jurjen Gerssen, Robert J van Ginkel, Hans W Nijman, Mitsuomi Hirashima, Toshiro Niki, Paul Eggleton, Wijnand Helfrich, Edwin Bremer
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e65616 (2013)
Galectin-9 (Gal-9) is known for induction of apoptosis in IFN-γ and IL-17 producing T-cells and amelioration of autoimmunity in murine models. On the other hand, Gal-9 induced IFN-γ positive T-cells in a sarcoma mouse model and in food allergy, sug
Externí odkaz:
https://doaj.org/article/178b512177d741349047e38af52a219e