Zobrazeno 1 - 10
of 1 982
pro vyhledávání: '"MITOTIC CHECKPOINT"'
Autor:
HOU Yiying, WEI Fang
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 12, Pp 1717-1721 (2024)
The BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) maintains a high fidelity of mitotic chromosome segregation by preventing the initiation of anaphase without the attachment of one or more kinetochore to the spindle, and plays a major rol
Externí odkaz:
https://doaj.org/article/5562fd34179b48829b44d642b0663cdd
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract The spindle assembly checkpoint (SAC) ensures chromosome segregation fidelity by manipulating unattached kinetochore‐dependent assembly of the mitotic checkpoint complex (MCC). The MCC binds to and inhibits the anaphase promoting complex/c
Externí odkaz:
https://doaj.org/article/a3d7929ddeff42388b6daf2ea3db6f97
Autor:
Elisa Zanini, Nicole Forster-Gross, Felix Bachmann, Adrian Brüngger, Paul McSheehy, Karine Litherland, Karin Burger, Anna C. Groner, Mila Roceri, Luc Bury, Martin Stieger, Nicole Willemsen-Seegers, Jos de Man, Diep Vu-Pham, Helma W. E. van Riel, Guido J. R. Zaman, Rogier C. Buijsman, Laurenz Kellenberger, Heidi A. Lane
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThreonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1) are common essential kinases that collaborate in activating the spindle assembly checkpoint (SAC) at the kinetochore, ensuring appropriate chromosome alignment and segregation pr
Externí odkaz:
https://doaj.org/article/cf9a84a3e06f4b3a99f2975a86de17db
Autor:
Nongnapas Pokaew, Piya Prajumwongs, Kulthida Vaeteewoottacharn, Sopit Wongkham, Chawalit Pairojkul, Kanlayanee Sawanyawisuth
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1611 (2024)
Budding Uninhibited by Benzimidazole-Related 1 (BubR1) or BUB1 Mitotic Checkpoint Serine/Threonine Kinase B (BUB1B) is an essential component of the spindle assembly checkpoint (SAC), which controls chromosome separation during mitosis. Overexpressio
Externí odkaz:
https://doaj.org/article/21c3bc3e0400495b828fb38ecaef4df6
Publikováno v:
Chinese Journal of Lung Cancer, Vol 26, Iss 4, Pp 310-318 (2023)
Spindle assembly checkpoint (SAC) is a protective mechanism for cells to undergo accurate mitosis. SAC prevented chromosome segregation when kinetochores were not, or incorrectly attached to microtubules in the anaphase of mitosis, thus avoiding aneu
Externí odkaz:
https://doaj.org/article/56fa1a86c3324ab8bf32979a8897ef66
Autor:
Li-Ting Qin, Si-Wei Huang, Zhi-Guang Huang, Yi-Wu Dang, Ye-Ying Fang, Juan He, Yi-Tong Niu, Cai-Xing Lin, Ji-Yun Wu, Zhu-Xin Wei
Publikováno v:
BMC Medical Genomics, Vol 15, Iss 1, Pp 1-15 (2022)
Abstract Nasopharyngeal carcinoma (NPC) has insidious onset, late clinical diagnosis and high recurrence rate, which leads to poor quality of patient life. Therefore, it is necessary to further explore the pathogenesis and therapy targets of NPC. BUB
Externí odkaz:
https://doaj.org/article/e6eb68f28f9f4d69a7f88ad8a6769fad
Akademický článek
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Autor:
Zichen He, Andrew Wilson, Fenella Rich, Diane Kenwright, Aaron Stevens, Yee Syuen Low, Michelle Thunders
Publikováno v:
Cancer Reports, Vol 6, Iss 6, Pp n/a-n/a (2023)
Abstract Background Cancer cell lines are invaluable model systems for biomedical research because they provide an almost unlimited supply of biological materials. However, there is considerable skepticism regarding the reproducibility of data derive
Externí odkaz:
https://doaj.org/article/6e0fa8497500496db52c81ae721aae39
Autor:
Samantha Bruno, Andrea Ghelli Luserna di Rorà, Roberta Napolitano, Simona Soverini, Giovanni Martinelli, Giorgia Simonetti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it controls the correct segregation of chromosomes during mitosis. Many studies have focused on the biological role of CDC20 in cancer development, as alter
Externí odkaz:
https://doaj.org/article/0c69bd628a4a45b0ad8924f3ed144bf6
Autor:
Eric M. C. Britigan, Jun Wan, Daniel K. Sam, Sarah E. Copeland, Amber L. Lasek, Laura C. F. Hrycyniak, Lei Wang, Anjon Audhya, Mark E. Burkard, Avtar Roopra, Beth A. Weaver
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Increased Aurora B protein expression, which is common in cancers, is expected to increase Aurora B kinase activity, yielding elevated phosphorylation of Aurora B substrates. In contrast, here we show that elevated expression of Aurora B reduces phos
Externí odkaz:
https://doaj.org/article/6fbce553832f4f44b8f03156cb8b9c18