Zobrazeno 1 - 10
of 223
pro vyhledávání: '"MITCH A. PHELPS"'
Autor:
Avinash K. Persaud, Matthew C. Bernier, Michael A. Massey, Shipra Agrawal, Tejinder Kaur, Debasis Nayak, Zhiliang Xie, Brenna Weadick, Ruchika Raj, Kasey Hill, Nicole Abbott, Arnav Joshi, Nadeen Anabtawi, Claire Bryant, Arpad Somogyi, Zobeida Cruz-Monserrate, Foued Amari, Vincenzo Coppola, Alex Sparreboom, Sharyn D. Baker, Jashvant D. Unadkat, Mitch A. Phelps, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Concentrative nucleoside transporters (CNTs) are active nucleoside influx systems, but their in vivo roles are poorly defined. By generating CNT1 knockout (KO) mice, here we identify a role of CNT1 in the renal reabsorption of nucleosides. D
Externí odkaz:
https://doaj.org/article/bab63ae328b3450a9e6f8d180eccc7bc
Autor:
Nathan D. Seligson, Xunjie Zhang, Mark C. Zemanek, Jasmine A. Johnson, Zachary VanGundy, Danxin Wang, Mitch A. Phelps, Julianna Roddy, Craig C. Hofmeister, Junan Li, Ming J. Poi
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Introduction: Polymorphisms in genes responsible for the metabolism and transport of tacrolimus have been demonstrated to influence clinical outcomes for patients following allogeneic hematologic stem cell transplant (allo-HSCT). However, the clinica
Externí odkaz:
https://doaj.org/article/74d23d0d6a3644e1ac4dd5f599fa8963
Autor:
Trang T. Vu, Kyeongmin Kim, Millennium Manna, Justin Thomas, Bryan C. Remaily, Emma J. Montgomery, Travis Costa, Lauren Granchie, Zhiliang Xie, Yizhen Guo, Min Chen, Alyssa Marie M. Castillo, Samuel K. Kulp, Xiaokui Mo, Sridhar Nimmagadda, Paul Gregorevic, Dwight H. Owen, Latha P. Ganesan, Thomas A. Mace, Christopher C. Coss, Mitch A. Phelps
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107048- (2024)
High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients. Mechanisms linking ICI clearance, cachexia and ICI therapy failure are unknown
Externí odkaz:
https://doaj.org/article/2e67e650671f4d189b77c2eafc481db4
Autor:
Nicole O. Williams, Dionisia Quiroga, Courtney Johnson, Adam Brufsky, Mara Chambers, Saveri Bhattacharya, Maria Patterson, Sagar D. Sardesai, Daniel Stover, Maryam Lustberg, Anne M. Noonan, Mathew Cherian, Darlene M. Bystry, Kasey L. Hill, Min Chen, Mitch A. Phelps, Michael Grever, Julie A. Stephens, Bhuvaneswari Ramaswamy, William E. Carson, Robert Wesolowski
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Background: Heat shock protein 90 (HSP90) is a molecular chaperone required for stabilization of client proteins over-activated in triple-negative breast cancer (TNBC). Over-expression of HSP90 client proteins has been implicated in paclitaxel resist
Externí odkaz:
https://doaj.org/article/c53632218637477c91145bbc4eb4d598
Autor:
Alyssa Marie M. Castillo, Trang T. Vu, Sophia G. Liva, Min Chen, Zhiliang Xie, Justin Thomas, Bryan Remaily, Yizhen Guo, Uma L. Subrayan, Travis Costa, Timothy H. Helms, Donald J. Irby, Kyeongmin Kim, Dwight H. Owen, Samuel K. Kulp, Thomas A. Mace, Mitch A. Phelps, Christopher C. Coss
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 2, Pp 232-244 (2021)
Abstract Background Monoclonal antibody (mAb) immune checkpoint inhibitor (ICI) therapies have dramatically impacted oncology this past decade. However, only about one‐third of patients respond to treatment, and biomarkers to predict responders are
Externí odkaz:
https://doaj.org/article/db94475297f14a02937ba2decc4f78d7
Autor:
Avinash K. Persaud, Matthew C. Bernier, Michael A. Massey, Shipra Agrawal, Tejinder Kaur, Debasis Nayak, Zhiliang Xie, Brenna Weadick, Ruchika Raj, Kasey Hill, Nicole Abbott, Arnav Joshi, Nadeen Anabtawi, Claire Bryant, Arpad Somogyi, Zobeida Cruz-Monserrate, Foued Amari, Vincenzo Coppola, Alex Sparreboom, Sharyn D. Baker, Jashvant D. Unadkat, Mitch A. Phelps, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/2b638685a878448bb21750b2e6773983
Autor:
Donald J. Irby, Mustafa E. Ibrahim, Anees M. Dauki, Mohamed A. Badawi, Sílvia M. Illamola, Mingqing Chen, Yuhuan Wang, Xiaoxi Liu, Mitch A. Phelps, Diane R. Mould
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 4, Pp 291-308 (2021)
Abstract Missing or erroneous information is a common problem in the analysis of pharmacokinetic (PK) data. This may present as missing or inaccurate dose level or dose time, drug concentrations below the analytical limit of quantification, missing s
Externí odkaz:
https://doaj.org/article/4bf8b31dc4b54808be5ad450089a9a56
Autor:
Timothy H. Helms, Riley D. Mullins, Jennifer M. Thomas-Ahner, Samuel K. Kulp, Moray J. Campbell, Fabienne Lucas, Nathan Schmidt, Dana M. LeMoine, Surafel Getaneh, Zhiliang Xie, Mitch A. Phelps, Steven K. Clinton, Christopher C. Coss
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract A promotional role for androgen receptor (AR) signaling in hepatocellular carcinogenesis is emerging. In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatoca
Externí odkaz:
https://doaj.org/article/c25b0208e10b4d27952527a2f7974c56
Autor:
Alireza Safa, Allison R. Lau, Sydney Aten, Karl Schilling, Karen L. Bales, Victoria A. Miller, Julie Fitzgerald, Min Chen, Kasey Hill, Kyle Dzwigalski, Karl Obrietan, Mitch A. Phelps, Wolfgang Sadee, John Oberdick
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Newborns exposed to prenatal opioids often experience intense postnatal withdrawal after cessation of the opioid, called neonatal opioid withdrawal syndrome (NOWS), with limited pre- and postnatal therapeutic options available. In a prior study in pr
Externí odkaz:
https://doaj.org/article/8682fde484134ec2b6aa095fb25e2262
Autor:
Dhruvitkumar S. Sutaria, Jinmai Jiang, Ola A. Elgamal, Steven M. Pomeroy, Mohamed Badawi, Xiaohua Zhu, Ryan Pavlovicz, Ana Clara P. Azevedo-Pouly, Jeffrey Chalmers, Chenglong Li, Mitch A. Phelps, Thomas D. Schmittgen
Publikováno v:
Journal of Extracellular Vesicles, Vol 6, Iss 1 (2017)
Extracellular vesicles (EVs) hold great potential as novel systems for nucleic acid delivery due to their natural composition. Our goal was to load EVs with microRNA that are synthesized by the cells that produce the EVs. HEK293T cells were engineere
Externí odkaz:
https://doaj.org/article/7c22fd9364884b21810f63bf8ad71308