Zobrazeno 1 - 10
of 31
pro vyhledávání: '"MIRZA MUHAMMAD FAHD QADIR"'
Autor:
Luciana Mateus Gonçalves, Mirza Muhammad Fahd Qadir, Maria Boulina, Madina Makhmutova, Elizabeth Pereira, Joana Almaça
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112913- (2023)
Summary: Pancreatic islets are endocrine organs that depend on their microvasculature to function. Along with endothelial cells, pericytes comprise the islet microvascular network. These mural cells are crucial for microvascular stability and functio
Externí odkaz:
https://doaj.org/article/4e192eb5f2dc482c9e6f9eb1a20b3cc0
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The ability to culture live pancreatic tissue slices for long periods of time would enable longitudinal studies ex vivo. Here the authors culture human and mouse pancreatic slices in a perfluorocarbon-based culture system and show stable endocrine an
Externí odkaz:
https://doaj.org/article/e297d8d44f204d96a98c13a905c50452
Autor:
Mirza Muhammad Fahd Qadir, Manika Bhondeley, Wandy Beatty, Dina D. Gaupp, Lara A. Doyle-Meyers, Tracy Fischer, Ishitri Bandyopadhyay, Robert V. Blair, Rudolf Bohm, Jay Rappaport, Eric Lazartigues, Richard S. Vander Heide, Jay K. Kolls, Xuebin Qin, Franck Mauvais-Jarvis
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Evidence suggests an association between severe acute respiratory syndrome–cornavirus-2 (SARS-CoV-2) infection and the occurrence of new-onset diabetes. We examined pancreatic expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane s
Externí odkaz:
https://doaj.org/article/ab20e4679d6241fc94e5adaa63e03b0e
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Kinsley Belle, Tamar Sapir, Fanuel Messaggio, Kevin B. Johnson, Oliver Umland, Darrell Hardin, Dagmar Klein, Ingrid Pérez-Álvarez, Fatima Sadiq, Oscar Alcázar, Luca A. Inverardi, Camillo Ricordi, Peter Buchwald, Christopher A. Fraker, Ricardo L. Pastori, Juan Domínguez-Bendala
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 611-623 (2019)
Summary: The transplantation of human embryonic stem cell (hESC)-derived insulin-producing β cells for the treatment of diabetes is finally approaching the clinical stage. However, even with state-of-the-art differentiation protocols, a significant
Externí odkaz:
https://doaj.org/article/4370bf27b2c441a0890f656127747865
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Dagmar Klein, Giacomo Lanzoni, Carlos García-Santana, Abelardo Montalvo, Fabiola Pláceres-Uray, Emilia Maria Cristina Mazza, Camillo Ricordi, Luca Alessandro Inverardi, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2408-2420 (2018)
Summary: Treatment of human pancreatic non-endocrine tissue with Bone Morphogenetic Protein 7 (BMP-7) leads to the formation of glucose-responsive β-like cells. Here, we show that BMP-7 acts on extrainsular cells expressing PDX1 and the BMP receptor
Externí odkaz:
https://doaj.org/article/2c05052cc5ed4b3f80bd04bc9324c419
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/2a1cc15a96f04c4e9605fe345f65874d
Publikováno v:
Trends Endocrinol Metab
The application of single-cell analytic techniques to the study of stem/progenitor cell niches supports the emerging view that pancreatic cell lineages are in a state of flux between differentiation stages. For all their value, however, such analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c13a9794a9a6eab28430dfbfea64cda
https://doi.org/10.1016/j.tem.2021.04.009
https://doi.org/10.1016/j.tem.2021.04.009
Autor:
SILVIA ALVAREZ-CUBELA, DAGMAR KLEIN, CHARLES G. ALVER, MIRZA MUHAMMAD FAHD QADIR, LUCIANA MATEUS GONCALVES, FARHAN QURESHI, JOANA ALMACA, CHRISTOPHER FRAKER, ALEJANDRO CAICEDO, ALBERTO PUGLIESE, CAMILLO RICORDI, ELISA OLTRA, ASHUTOSH G. AGARWAL, RICARDO PASTORI, JUAN DOMÍNGUEZ-BENDALA
Publikováno v:
Diabetes. 71
Introduction: The study of pancreatic regeneration would benefit greatly from the design and validation of robust human-based models. Human Pancreatic Slices (HPSs) are thin organotypic sections of live pancreatic tissue. The sectioning method preser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ab35f62fc17727fe8d85f4a813d83d7
https://doi.org/10.2337/db22-251-lb
https://doi.org/10.2337/db22-251-lb
Autor:
PAULA MOTA DE SA, MIRZA MUHAMMAD FAHD QADIR, MANUEL BLANDINO-ROSANO, JIA FAN, WEIWEI XU, ERNESTO BERNAL-MIZRACHI, FRANCK MAUVAIS-JARVIS
Publikováno v:
Diabetes. 71
Male mice lacking the androgen receptor (AR) in islet β cells exhibit blunted glucose-stimulated insulin secretion (GSIS) , leading to hypoinsulinemia and hyperglycemia. We showed that dihydrotestosterone (DHT) activation of an extranuclear AR in β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::524b4a9bd1f07092f4f571cf04faf076
https://doi.org/10.2337/db22-1456-p
https://doi.org/10.2337/db22-1456-p
Autor:
MIRZA MUHAMMAD FAHD QADIR, WEIWEI XU, DANIELA NASTESKA, MANIKA BHONDELEY, PAULA MOTA DE SA, CHARLES R. EVANS, JOCHEN BUCK, LONNY LEVIN, CHARLES BURANT, DAVID HODSON, FRANCK MAUVAIS-JARVIS
Publikováno v:
Diabetes. 71
Male mice with elimination of the androgen receptor (AR) in islet β cells (βARKO) exhibit blunted glucose-stimulated insulin secretion (GSIS) , leading to hypoinsulinemia and hyperglycemia. We showed that dihydrotestosterone (DHT) activation of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa7e52881982619abe0e1ca03c4b8f72
https://doi.org/10.2337/db22-1474-p
https://doi.org/10.2337/db22-1474-p