Zobrazeno 1 - 10
of 209
pro vyhledávání: '"MING-DERG LAI"'
Autor:
Shiang-Jie Yang, Sheng-Tsung Chang, Kung-Chao Chang, Bo-Wen Lin, Kwang-Yu Chang, Yao-Wen Liu, Ming-Derg Lai, Liang-Yi Hung
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Cancer cells can evade immune elimination by activating immunosuppressive signaling pathways in the tumor microenvironment (TME). Targeting immunosuppressive signaling pathways to promote antitumor immunity has become an attractive strategy
Externí odkaz:
https://doaj.org/article/b94056659c6b490db5774d2e266dbf85
Autor:
Feng-Wei Chen, Yung-Ling Wu, Chao-Chun Cheng, Yu-Wei Hsiao, Jhih-Ying Chi, Liang-Yi Hung, Chih-Peng Chang, Ming-Derg Lai, Ju-Ming Wang
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-19 (2024)
Abstract Background The tumor microenvironment is characterized by inflammation-like and immunosuppression situations. Although cancer-associated fibroblasts (CAFs) are among the major stromal cell types in various solid cancers, including colon canc
Externí odkaz:
https://doaj.org/article/fc78de390566478a976181459c9e7cc0
Autor:
Chung-Yen Li, Gangga Anuraga, Chih-Peng Chang, Tzu-Yang Weng, Hui-Ping Hsu, Hoang Dang Khoa Ta, Pei-Fang Su, Pin-Hsuan Chiu, Shiang-Jie Yang, Feng-Wei Chen, Pei-Hsuan Ye, Chih-Yang Wang, Ming-Derg Lai
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-22 (2023)
Abstract Background Nitric oxide-releasing drugs are used for cardiovascular diseases; however, their effects on the tumor immune microenvironment are less clear. Therefore, this study explored the impact of nitric oxide donors on tumor progression i
Externí odkaz:
https://doaj.org/article/db9c532167bf4e4c8e7ab9851c25166b
Autor:
Yen-Hung Wu, I-Jeng Yeh, Nam Nhut Phan, Meng-Chi Yen, Jui-Hsiang Hung, Chung-Chieh Chiao, Chien-Fu Chen, Zhengda Sun, Hui-Ping Hsu, Chih-Yang Wang, Ming-Derg Lai
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 54, Iss 5, Pp 845-857 (2021)
Background: Pathogenic coronaviruses include Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and SARS-CoV-2. These viruses have induced outbreaks worldwide, and there are currently no
Externí odkaz:
https://doaj.org/article/7e6444b82eac4c1286777a043bf79e7a
Autor:
Che-Yuan Hu, Chi-Feng Hung, Pi-Che Chen, Jia-Yu Hsu, Chung-Teng Wang, Ming-Derg Lai, Yuh-Shyan Tsai, Ai-Li Shiau, Gia-Shing Shieh, Chao-Liang Wu
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2598 (2023)
Immunotherapy has emerged as a promising modality for cancer treatment. Dendritic cell immunoreceptor (DCIR), a C-type lectin receptor, is expressed mainly by dendritic cells (DCs) and mediates inhibitory intracellular signaling. Inhibition of DCIR a
Externí odkaz:
https://doaj.org/article/3d33ad029c674c0685ee1e0eeb188d69
Autor:
Shao-Ming Wang, Sher-Wei Lim, Ya-Han Wang, Hong-Yi Lin, Ming-Derg Lai, Chiung-Yuan Ko, Ju-Ming Wang
Publikováno v:
Redox Biology, Vol 16, Iss , Pp 104-112 (2018)
Excessive reactive oxygen species (ROS) can form an oxidative stress and an associated neuroinflammation. However, the contribution of astrocytes to ROS formation, the cause of the resistance of astrocytes to oxidative stress, and the consequences on
Externí odkaz:
https://doaj.org/article/6a5cb95f678c4e63affae58933ddabc8
Autor:
Tzu-Yang Weng, Chia-Jung Li, Chung-Yen Li, Yu-Hsuan Hung, Meng-Chi Yen, Yu-Wei Chang, Yu-Hung Chen, Yi-Ling Chen, Hui-Ping Hsu, Jang-Yang Chang, Ming-Derg Lai
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 419-427 (2017)
Clec4a has been reported to be an immune suppressor of dendritic cells (DCs), but its potential role in cancer therapy remains to be elucidated. The present study investigated whether downregulating the expression of Clec4a via skin delivery of small
Externí odkaz:
https://doaj.org/article/ce0629a3fb0b40d9a20fb951640d29af
Autor:
Hui-Ping Hsu, Ming-Derg Lai, Jenq-Chang Lee, Meng-Chi Yen, Tzu-Yang Weng, Wei-Ching Chen, Jung-Hua Fang, Yi-Ling Chen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Downregulation of Mucin 2 (MUC2) expression is associated with early carcinogenesis events in colon cancer. MUC2 plays a role in the progression of colon cancer, and reduced MUC2 protein expression correlates with increased interleukin-6 (IL
Externí odkaz:
https://doaj.org/article/b26b679bc14e475ebaf6edd19ce6bd06
Autor:
Zhengda Sun, Devon A. Lawson, Elizabeth Sinclair, Chih-Yang Wang, Ming-Derg Lai, Steven W. Hetts, Randall T. Higashida, Christopher F. Dowd, Van V. Halbach, Zena Werb, Hua Su, Daniel L. Cooke
Publikováno v:
Biotechnology Reports, Vol 7, Iss C, Pp 157-165 (2015)
Purpose: To develop a strategy of achieving targeted collection of endothelial cells (ECs) by endovascular methods and analyzing the gene expression profiles of collected single ECs. Methods and results: 134 ECs and 37 leukocytes were collected from
Externí odkaz:
https://doaj.org/article/878189fa67264805b5536908b09393cd
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155660 (2016)
Dysregulated lipid metabolism contributes to cancer progression. Our previous study indicates that long-chain fatty acyl-Co A synthetase (ACSL) 3 is essential for lipid upregulation induced by endoplasmic reticulum stress. In this report, we aimed to
Externí odkaz:
https://doaj.org/article/107019bc5f6c4789b25f762a935c98d5