Zobrazeno 1 - 10
of 33
pro vyhledávání: '"MIKAEL GILLNER"'
Autor:
Mikael Gillner, Anthony P. H. Wright, Paulette Greenidge, Konrad F. Koehler, Jan Carlstedt-Duke, Ulrika Lind
Publikováno v:
Journal of Biological Chemistry. 275:19041-19049
To elucidate which amino acids in the glucocorticoid receptor ligand-binding domain might be involved in determining steroid binding specificity by interaction with the D-ring of glucocorticoids, we have performed site-directed mutagenesis of the fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb0da368a5cb4a8b8ccc1eb80022c95
https://doi.org/10.1074/jbc.m000228200
https://doi.org/10.1074/jbc.m000228200
Publikováno v:
Journal of Medicinal Chemistry. 41:2503-2512
In the present study we investigate whether augmentation of pharmacophores with excluded (ligand-inaccessible) volumes can condense the lengthy unspecific hit lists often obtained in 3D-database searching. Our pharmacophores contained hydrophobic fea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a6d838b9e367589687af2f696f248b
https://doi.org/10.1021/jm9708691
https://doi.org/10.1021/jm9708691
Publikováno v:
Current Opinion in Immunology. 5:579-584
Major emphasis is currently being placed on unraveling the molecular basis of various forms of primary human immunodeficiencies. It is clear from recent studies that not only can different mutations give rise to different phenotypes but the same muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d1a9120901f4820227a65b7405302a
https://doi.org/10.1016/0952-7915(93)90041-p
https://doi.org/10.1016/0952-7915(93)90041-p
Autor:
Herbert S. Rosenkranz, Ulf Rannug, Michael Sjögren, Mikael Gillner, Jan-Åke Gustafsson, Agneta Rannug, Gilles Klopman, Rune Toftgård
Publikováno v:
Carcinogenesis. 12:2007-2015
The Computer-Automated Structure Evaluation (CASE) Program, an expert system that automatically selects relevant descriptors for structure-activity relationships, has been used to analyze the binding of various ligands to the tetrachloro-dibenzo-p-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a212ddc4a0c906b80f5e5e4e812847
https://doi.org/10.1093/carcin/12.11.2007
https://doi.org/10.1093/carcin/12.11.2007
Autor:
Tommy Johansson, Ivan Romero, Emma Dahlstedt, Mikael Gillner, Linda Rickardson, Marita Högberg, Olof Smitt
Publikováno v:
Molecular Cancer Therapeutics. 12:A298-A298
Purpose: Microtubule targeting agents, represented by vinca alkaloids and taxanes, are extensively used in the clinic with good effects. However, these large molecules can only be administered by intravenous injections to the patient and they are als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ddbe9a78aebf1077bd6be4add870f2e
https://doi.org/10.1158/1535-7163.targ-13-a298
https://doi.org/10.1158/1535-7163.targ-13-a298
Autor:
Henry J. Barnes, Johan Lund, Mikael Gillner, Lena Nordlund-Möller, Jan-Åke Gustafsson, Olof Andersson, Magnus Nord
Publikováno v:
Journal of molecular biology. 256(2)
Uteroglobins, i.e. proteins with similar three-dimensional structure and ligand binding specificity to uteroglobin from rabbit uterus, have been found in rat, mouse and human lung. We have recently demonstrated the binding of calcium by human uterogl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fe2903034e48b570b4bcdae963c42c
https://pubmed.ncbi.nlm.nih.gov/8594205
https://pubmed.ncbi.nlm.nih.gov/8594205
Publikováno v:
Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds ISBN: 9781468472868
The relative amounts of some of the cytochrome P-450 enzymes are known to be selectively increased by chemicals (Conney, 1982, Whit lock, 1986). Especially interesting is the induction of certain forms of cytochrome P-450 by 5,6-benzof lavone (BNF),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57413d65b79681ce1ec3212a092172ba
https://doi.org/10.1007/978-1-4684-7284-4_16
https://doi.org/10.1007/978-1-4684-7284-4_16
Autor:
Mikael Gillner, R. Ahlgren, Lena Nordlund-Möller, Johan Lund, Olof Andersson, J Schilling, J-Å Gustafsson
Publikováno v:
The Journal of biological chemistry. 265(21)
Certain metabolites of polychlorinated biphenyls (PCBs) are retained in the Clara cells and in the airway lumen of rodent lung due to their interaction with a secretory 13-kDa protein. Here, we report the isolation of a cDNA encoding the rat lung PCB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dfe14656cd1485b50b31837f418aee
https://pubmed.ncbi.nlm.nih.gov/2115524
https://pubmed.ncbi.nlm.nih.gov/2115524
Autor:
Mikael Gillner, Bertil Högberg, Jan Carlstedt-Duke, Johan Lund, Jan-Åke Gustafsson, Rabinder N. Kurl, Lorenz Poellinger
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 714:516-523
The intranuclear binding of radioactive 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) in rat liver has been studied both in vivo and in vitro. Following the intravenous administration of [1,6- 3 H]TCDD, a maximum uptake by cell nuclei could be observe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d1550061ff2007df615c4ec2d646b4
https://doi.org/10.1016/0304-4165(82)90162-3
https://doi.org/10.1016/0304-4165(82)90162-3
Autor:
Mikael Gillner, Christian Cambillau, Jan-Ake Gustafsson, M. Alexandersson, Å Bergman, U. Hurtig, E. Klasson-Wehler, Johan Lund
Publikováno v:
Journal of Steroid Biochemistry. 31:27-33
The binding of methylsulfonyl-polychloro-biphenyls (methylsulfonyl-PCBs) to purified uteroglobin was studied by a dextran-coated charcoal assay using 4,4'-bis([ 3H]methylsulfonyl)-2,2',5,5'-tetrachlorobiphenyl [(3H-MeSO2)2TCB] as radiolabeled ligand.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e4bd9a6c5bc7ff207eecae637cdd8f
https://doi.org/10.1016/0022-4731(88)90201-4
https://doi.org/10.1016/0022-4731(88)90201-4