Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes

Autor: Thomas H Julian, Nicholas Glascow, A Dylan Fisher Barry, Tobias Moll, Calum Harvey, Yann C Klimentidis, Michelle Newell, Sai Zhang, Michael P Snyder, Johnathan Cooper-Knock, Pamela J Shaw

Publikováno v: EBioMedicine, Vol 68, Iss , Pp 103397- (2021)

Background: Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease. ALS is determined by gene-environment interactions and improved understanding of these interactions may lead to effective personalised medicine. The rol

Externí odkaz: https://doaj.org/article/b14f3c3d161c4cbdb4b00a743b2e8d20

Identification of genetic loci simultaneously associated with multiple cardiometabolic traits

Autor: Alexis C. Wood, Amit Arora, Michelle Newell, Victoria L. Bland, Jin Zhou, Nicola Pirastu, Jose M. Ordovas, Yann C. Klimentidis

Publikováno v: Wood, A C, Arora, A, Newell, M, Bland, V L, Zhou, J, Pirastu, N, Ordovas, J M & Klimentidis, Y C 2022, ' Identification of genetic loci simultaneously associated with multiple cardiometabolic traits ', Nutrition, Metabolism and Cardiovascular Diseases, vol. 32, no. 4, pp. 1027-1034 . https://doi.org/10.1016/j.numecd.2022.01.002
Nutr Metab Cardiovasc Dis

Background and AimsCardiometabolic disorders (CMD) arise from a constellation of features such as increased adiposity, hyperlipidemia, hypertension and compromised glucose control. Many genetic loci have shown associations with individual CMD-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa8ebf1e6e5a094873a9521606f1634
https://doi.org/10.1016/j.numecd.2022.01.002

1137-P: Continuous Glucose Monitoring (CGM) Use and Its Impact on Glycemic Control and Acute Complications among Older-Onset Type 1 Diabetes Patients within the Veterans Health Administration (VHA)

Autor: JIN ZHOU, MICHELLE NEWELL, SALVADOR RIVAS, XINKAI ZHOU, GREGORY J. NORMAN, PETER REAVEN

Publikováno v: Diabetes. 71

There is increasing recognition that older onset type 1 diabetes (T1D) is not uncommon. Although CGM use is rising dramatically among those with T1D, little is known regarding its use and benefits within this older T1D population. To address these qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f17bbc5a76f00c35232c0d46a3b48081
https://doi.org/10.2337/db22-1137-p

Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank

Autor: Amit Arora, Alexis C. Wood, Michelle Newell, Benjamin J. Renquist, Jose M. Ordovas, Jin Zhou, Yann C. Klimentidis

Publikováno v: Diabetes

Although hyperlipidemia is traditionally considered a risk factor for type 2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL cholesterol (LDL-C) increases T2D risk. We thus sought to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e9cd5d55afc44ec1a1688fb2b969aa
http://europepmc.org/articles/PMC7506834

Phenotypic and genetic characterization of lower LDL-C and increased type-2 diabetes risk in the UK Biobank

Autor: Alexis C. Wood, Benjamin J. Renquist, Jose M. Ordovas, Jin Zhou, Michelle Newell, Amit Arora, Yann C. Klimentidis, Ada Admin

Although hyperlipidemia is traditionally considered a risk factor for type-2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL-C increases T2D risk. We thus sought to more comprehensiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb86d70ccf09b2661250d9f15f291a5
https://doi.org/10.2337/figshare.12389273.v1