Zobrazeno 1 - 10
of 82
pro vyhledávání: '"MICHAEL R. VASKO"'
Autor:
Ragini Vittal, Amanda J. Fisher, Eric L. Thompson, Ellyse M. Cipolla, Hongmei Gu, Elizabeth A. Mickler, Ananya Varre, Manisha Agarwal, Kevin K. Kim, Michael R. Vasko, Bethany B. Moore, Vibha N. Lama
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:459-470
CD55 or decay accelerating factor (DAF), a ubiquitously expressed glycosylphosphatidylinositol (GPI)-anchored protein, confers a protective threshold against complement dysregulation which is linked to the pathogenesis of idiopathic pulmonary fibrosi
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104529 (2014)
We examined whether nerve growth factor (NGF), an inflammatory mediator that contributes to chronic hypersensitivity, alters the intracellular signaling that mediates the sensitizing actions of PGE2 from activation of protein kinase A (PKA) to exchan
Externí odkaz:
https://doaj.org/article/5ba58510d4a94797a3a87966b7efaadb
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106485 (2014)
Although chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of platinum drugs, the mechanisms of this toxicity remain unknown. Previous work in our laboratory suggests that cisplatin-induced CIPN is secondary to DNA dama
Externí odkaz:
https://doaj.org/article/40cd0620932046fbb7a88a310540a022
Publikováno v:
Molecular and Cellular Neuroscience. 70:54-67
Guanine nucleotide exchange factors directly activated by cAMP (Epacs) have emerged as important signaling molecules mediating persistent hypersensitivity in animal models of inflammation, by augmenting the excitability of sensory neurons. Although E
Autor:
Michael R. Vasko, Suk Hee Lee, Eric L. Thompson, Mark R. Kelley, Hyun Suk Kim, Chunlu Guo, Yanlin Jiang
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 779:96-104
Peripheral neuropathy is one of the major side effects of treatment with the anticancer drug, cisplatin. One proposed mechanism for this neurotoxicity is the formation of platinum adducts in sensory neurons that could contribute to DNA damage. Althou
Although inflammation-induced peripheral sensitization oftentimes resolves as an injury heals, this sensitization can be pathologically maintained and contribute to chronic inflammatory pain. Numerous inflammatory mediators increase the production of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d436e42d68c5ad48850bf79a78ceb35a
https://europepmc.org/articles/PMC5954980/
https://europepmc.org/articles/PMC5954980/
Autor:
Alexander V. Sorokin, Daisy Zamora, Santosh K. Mishra, Michael J. Iadarola, Danielle M. LaPaglia, Christopher E. Ramsden, Joshua J. Wheeler, Zhi-Xin Yuan, Anthony F. Domenichiello, John M. Davis, Michael R. Vasko, Mark S. Horowitz, Matthew R. Sapio, Amit K. Dey, Nehal N. Mehta, Andrew J. Mannes, Sharon F. Majchrzak-Hong, Jacklyn R. Gross, Gregory S. Keyes
Chronic pain and itch are common hypersensitivity syndromes that are affected by endogenous mediators. We applied a systems-based, translational approach to predict, discover, and characterize mediators of pain and itch that are regulated by diet and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08679686abbed4b176fc85779619fbc
https://europepmc.org/articles/PMC5805383/
https://europepmc.org/articles/PMC5805383/
Publikováno v:
Journal of Neuroinflammation
Background Acute exposure to prostaglandin E2 (PGE2) activates EP receptors in sensory neurons which triggers the cAMP-dependent protein kinase A (PKA) signaling cascade resulting in enhanced excitability of the neurons. With long-term exposure to PG
Autor:
James H. Wikel, Mark R. Kelley, Chunlu Guo, Michael R. Vasko, Melissa L. Fishel, Karen E. Pollok, Barbara J. Bailey, Randy Wireman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 359(2)
Chemotherapy-induced peripheral neuropathy (CIPN) is a potentially debilitating side effect of a number of chemotherapeutic agents. There are currently no U.S. Food and Drug Administration-approved interventions or prevention strategies for CIPN. Alt
Autor:
David A. Flockhart, Behzad Shariati, Jason D. Robarge, Ruizhong Wang, Djane B. Duarte, Michael R. Vasko
Although aromatase inhibitors (AIs) are commonly used therapies for breast cancer, their use is limited because they produce arthralgia in a large number of patients. To determine whether AIs produce hypersensitivity in animal models of pain, we exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9ff15de207d8e3852f462032d00a54
https://europepmc.org/articles/PMC4877294/
https://europepmc.org/articles/PMC4877294/