Zobrazeno 1 - 10
of 680
pro vyhledávání: '"MICHAEL P. LISANTI"'
Autor:
Marta Mauro-Lizcano, Filippo Di Pisa, Luis Larrea Murillo, Conor J. Sugden, Federica Sotgia, Michael P. Lisanti
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-13 (2024)
Abstract Here, we examined the potential role of mitochondrial DNA (mtDNA) levels in conveying aggressive phenotypes in cancer cells, using two widely-used breast cell lines as model systems (MCF7[ER+] and MDA-MB-231[ER-]). These human breast cancer
Externí odkaz:
https://doaj.org/article/d958f5e76ee84067bc0ca9f7782ac59c
Publikováno v:
Cells, Vol 13, Iss 10, p 841 (2024)
Although cellular senescence was originally defined as an irreversible form of cell cycle arrest, in therapy-induced senescence models, the emergence of proliferative senescence-escaped cancer cells has been reported by several groups, challenging th
Externí odkaz:
https://doaj.org/article/8ab5f7bfa7794efca2bd76edf57859fd
Autor:
Marco Fiorillo, Elena Ricci, Mariarosa Fava, Camilla Longobucco, Federica Sotgia, Pietro Rizza, Marilena Lanzino, Daniela Bonofiglio, Francesca Luisa Conforti, Stefania Catalano, Ines Barone, Catia Morelli, Saveria Aquila, Michael P. Lisanti, Diego Sisci
Publikováno v:
Cells, Vol 12, Iss 24, p 2777 (2023)
Tamoxifen-resistant breast cancer cells (TamR-BCCs) are characterized by an enhanced metabolic phenotype compared to tamoxifen-sensitive cells. FoxO3a is an important modulator of cell metabolism, and its deregulation has been involved in the acquisi
Externí odkaz:
https://doaj.org/article/a318d65fff1b4bb8820e166359d731bb
Autor:
Baljinder Kaur, Yahya Sohrabi, Abhinav Achreja, Michael P. Lisanti, Ubaldo Emilio Martinez-Outschoorn
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/d118893d69ff4a1ea6f3116c1a9c92ee
Autor:
Filippo Di Pisa, Elisa Pesenti, Maria Bono, Andrea N. Mazzarello, Cinzia Bernardi, Michael P. Lisanti, Giovanni Renzone, Andrea Scaloni, Ermanno Ciccone, Franco Fais, Silvia Bruno, Paolo Scartezzini, Fabio Ghiotto
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background The human SH3 domain Binding Glutamic acid Rich Like 3 (SH3BGRL3) gene is highly conserved in phylogeny and widely expressed in human tissues. However, its function is largely undetermined. The protein was found to be overexpresse
Externí odkaz:
https://doaj.org/article/bdaeeebccdf8400995bd192ebe53393f
New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes
Autor:
Cristian Scatena, Giovanni Fanelli, Giuseppe Nicolò Fanelli, Michele Menicagli, Paolo Aretini, Valerio Ortenzi, Sara Piera Civitelli, Lorenzo Innocenti, Federica Sotgia, Michael P. Lisanti, Antonio Giuseppe Naccarato
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Recent evidence suggests that a loss of expression of caveolin in the stromal compartment (sCav-1) of human invasive breast carcinoma (IBC) may be a predictor of disease recurrence, metastasis and poor outcome. At present, there is little kn
Externí odkaz:
https://doaj.org/article/daa8355ce42840c988783df105fba6a4
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Recently, we presented evidence that high mitochondrial ATP production is a new therapeutic target for cancer treatment. Using ATP as a biomarker, we isolated the “metabolically fittest” cancer cells from the total cell population. Importantly, A
Externí odkaz:
https://doaj.org/article/60572a77be624bc495261202d31f4c9b
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
MitoTracker Deep Red (MTDR) is a relatively non-toxic, carbocyanine-based, far-red, fluorescent probe that is routinely used to chemically mark and visualize mitochondria in living cells. Previously, we used MTDR at low nano-molar concentrations to s
Externí odkaz:
https://doaj.org/article/8099c2cd0db642268c25c292aebc1b54
Autor:
Rosa Sánchez-Alvarez, Ernestina Marianna De Francesco, Marco Fiorillo, Federica Sotgia, Michael P. Lisanti
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Elevated mitochondrial biogenesis and metabolism represent key features of breast cancer stem cells (CSCs), whose propagation is conducive to disease onset and progression. Therefore, interfering with mitochondria biology and function may be regarded
Externí odkaz:
https://doaj.org/article/8b1850cf07814085b3ed4409d1e29d0f
Autor:
Béla Ózsvári, Luma G. Magalhães, Joe Latimer, Jussi Kangasmetsa, Federica Sotgia, Michael P. Lisanti
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Here, we describe the chemical synthesis and biological activity of a new Doxycycline derivative, designed specifically to more effectively target cancer stem cells (CSCs). In this analog, a myristic acid (14 carbon) moiety is covalently attached to
Externí odkaz:
https://doaj.org/article/8c80ce471acf425ca74005bae7311c97