Syncope after successful implantation of atrioventricular synchronous leadless pacemaker caused by polymorphic ventricular tachycardia

Autor: Ahmad Halawa, MD, Martin Aguilar, MD, PhD, Michael O. Sweeney, MD, Sunil Kapur, MD, FHRS

Publikováno v: HeartRhythm Case Reports, Vol 6, Iss 8, Pp 503-506 (2020)

Externí odkaz: https://doaj.org/article/f7f86b1c2b91477ab0838814e4d97e7b

Acute flaccid myelitis

Autor: Jessica Rice, Janet Dean, Andrew Pekosz, Priya Duggal, Jonathan B. Strober, Matthew J. Elrick, Raquel Farias-Moeller, Sue Hong, Cristina L. Sadowsky, Leslie Benson, Thomas O. Crawford, Nalin Gupta, Amy Bayliss, Kavita Thakkar, Ryutaro Kira, Samuel R. Dominguez, Pin Fee Chong, Meghan Moore, Eoin P. Flanagan, Melania Bembea, S. K. Das, Jason Zucker, Maria A. Garcia-Dominguez, Naila Makhani, Molly Wilson-Murphy, Jiri Vajsar, Wendy Vargas, Payal Patel, Nusrat Ahsan, Mark J. Abzug, Olwen C. Murphy, Roberta L. DeBiasi, Kevin Messacar, Gabrielle deFiebre, Sarah Hopkins, Glendaliz Bosques, Gadi Revivo, Kristen Chao, Dennis W. Simon, Anusha K. Yeshokumar, Joyce Oleszek, Jay Desai, Lileth Mondok, Apurva Shah, Amary Fall, Benjamin Greenberg, Dawn Deike, Dan Zlotolow, Jessica Nance, Michelle Melicosta, Kaitlin Hagen, Divakar Mithal, Grace Y. Gombolay, Jessica L. Carpenter, Caitlin O'Brien, Catherine Otten, Rebecca Riggs, Michael O. Sweeney, Allison Navis, NgocHanh Vu, Timothy Lotze, Vykuntaraju K Gowda, Matthew Vogt, E. Ann Yeh, Allan Belzberg, Leigh Ramos-Platt, Keith Van Haren, Andrea Bauer, Kendall B. Nash, Matthew Harmelink, Emmanuelle Tiongson, Margaret Tunney, Erlinda Ulloa, Eduardo Lopez, Michele L. Yang, Kiran T. Thakur, Elizabeth Wells, Courtney Porter, Chamindra Konersman, Matthew P. Kirschen, Craig A. Press, Andrea Salazar-Camelo, Elana Katz, William Jackson, Kristen Davidge, Jelte Helfferich, Teri Schreiner, Ann Tilton, Jacqueline S. Gofshteyn, Amy Moore, Ming K. Lim, Richard H. Scheuermann, Amy B. Rosenfeld, Charles Y. Chiu, Carolina M Carballo, Eliza Gordon-Lipkin, Peggy Lazerow, Carlos A. Pardo, Ari Bitnun, Jan Mendelt Tillema, Jonathan D. Cheng, Sabrina Yum, Aaron M. Milstone, John Luce, Colyn Watkins, Riley Bove, Megan Blaufuss, Sonal Bhatia, Mitchel Seruya

Publikováno v: Lancet
Lancet (London, England), vol 397, iss 10271

Acute flaccid myelitis (AFM) is a disabling, polio-like illness mainly affecting children. Outbreaks of AFM have occurred across multiple global regions since 2012, and the disease appears to be caused by non-polio enterovirus infection, posing a maj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68eddf40e4f7f4a3215ba77056cd9708
https://doi.org/10.1016/s0140-6736(20)32723-9

Effect of selective BET protein inhibitor apabetalone on cardiovascular outcomes in patients with acute coronary syndrome and diabetes: Rationale, design, and baseline characteristics of the BETonMACE trial

Autor: Ewelina Kulikowski, Kamyar Kalantar-Zadeh, Kausik K. Ray, Henry D Ginsberg, Norman C.W. Wong, Peter P. Toth, Jan O. Johansson, Stephen J. Nicholls, Michael O. Sweeney, Jeffrey L. Cummings, Gregory G. Schwartz

Publikováno v: American Heart Journal. 217:72-83

Background After an acute coronary syndrome (ACS), patients with diabetes remain at high risk for additional cardiovascular events despite use of current therapies. Bromodomain and extra-terminal (BET) proteins are epigenetic modulators of inflammati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd5056ad11317bbf05de93a9e53aebd
https://doi.org/10.1016/j.ahj.2019.08.001

MO072APABETALONE DOWNREGULATES FIBROTIC, INFLAMMATORY AND CALCIFIC PROCESSES IN RENAL MESANGIAL CELLS WHICH MAY CONTRIBUTE TO REDUCED CARDIAC EVENTS OBSERVED IN CKD PATIENTS

Autor: Laura Tsujikawa, Brooke Rakai, Li Fu, Kamyar Kalantar-Zadeh, Ravi Jahagirdar, Jan Johansson, Christopher Halliday, Christopher D. Sarsons, Sylwia Wasiak, Dean Gilham, Michael O. Sweeney, Norman C.W. Wong, Stephanie C. Stotz, Ewelina Kulikowski

Publikováno v: Nephrology Dialysis Transplantation. 36

Background and Aims Major adverse cardiac events (MACE) remain a leading cause of mortality in chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain & extraterminal (BET) proteins – epigenetic readers that modula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8285874fa178fe9aa0c6d6d30a01b3ff
https://doi.org/10.1093/ndt/gfab078.008

BET Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection

Autor: Cameron Bishop, Kathy Karavendzas, Kamil A. Sokolowski, Brian W.C. Tse, Brendan Griffen, Rajeev Rudraraju, Wei Zhao, Norman C.W. Wong, Charley Mackenzie-Kludas, Kelli P. A. MacDonald, Thuy T. Le, Sophie Krumeich, Gregory A. Quaife-Ryan, Leo J. Lee, Richard J. Mills, David A. Elliott, Stephen J. Nicholls, Holly K. Voges, Christian R. Engwerda, Daniel J. Rawle, Andreas Suhrbier, Li Fu, Jan Johansson, Rebecca L Johnston, Kanta Subbarao, Sean J. Humphrey, Mary Lor, James H McMahon, Enzo R. Porrello, Dad Abu-Bonsrah, Ewelina Kulikowski, Patrick R. J. Fortuna, Lynn Devilee, James E. Hudson, Tobias Bald, Troy Dumenil, Ellen Mathieson, Liam T Reynolds, David E. James, Michael O. Sweeney, Simon R. Foster, Drew M. Titmarsh, Christopher Halliday, Neda R Mehdiabadi, Dean Gilham, Mark J. Smyth

Publikováno v: Cell

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined, but could be direct cardiac infection and/or inflammation-induced dysfunction. To identify mechanisms and cardio-protective drugs, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8980f221c915141159a88aa5bcdc235
https://hdl.handle.net/2123/24826