Zobrazeno 1 - 10
of 74
pro vyhledávání: '"MICHAEL J. RUNSWICK"'
Autor:
Michael J. Runswick, John V. Bason, Martin G. Montgomery, Graham C. Robinson, Ian M. Fearnley, John E. Walker
Publikováno v:
Open Biology, Vol 3, Iss 2 (2013)
The mitochondrial F1-ATPase inhibitor protein, IF1, inhibits the hydrolytic, but not the synthetic activity of the F-ATP synthase, and requires the hydrolysis of ATP to form the inhibited complex. In this complex, the α-helical inhibitory region of
Externí odkaz:
https://doaj.org/article/cd035229ce724da68e175bd514bdacc5
Publikováno v:
Journal of Molecular Biology
In the structure of bovine F1-ATPase inhibited with residues 1–60 of the bovine inhibitor protein IF1, the α-helical inhibitor interacts with five of the nine subunits of F1-ATPase. In order to understand the contributions of individual amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de6008ee1bdd18f7682b5d4e4834fbf
Publikováno v:
Proceedings of the National Academy of Sciences. 107:16823-16827
The catalytic domain of the F-ATPase in mitochondria protrudes into the matrix of the organelle, and is attached to the membrane domain by central and peripheral stalks. Energy for the synthesis of ATP from ADP and phosphate is provided by the transm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4453f44b30c8b0a8c23bde4de42baa2
https://doi.org/10.1073/pnas.1011099107
https://doi.org/10.1073/pnas.1011099107
Autor:
Veronica Kane Dickson, John E. Walker, Andrew G. W. Leslie, Michael J. Runswick, Jocelyn A. Silvester
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 62:530-533
A subcomplex of the peripheral stalk or stator domain of the ATP synthase from bovine mitochondria has been expressed to high levels in a soluble form in Escherichia coli. The subcomplex consists of residues 79-184 of subunit b, residues 1-124 of sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ebc0725da096604192ca94cd1cea92
https://doi.org/10.1107/s1744309106015338
https://doi.org/10.1107/s1744309106015338
Publikováno v:
Journal of Molecular Biology. 342:593-603
The ATP synthase enzyme structure includes two stalk assemblies, the central stalk and the peripheral stalk. Catalysis involves rotation of the central stalk assembly together with the membrane-embedded ring of c-subunits driven by the trans-membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a809e7260ceaf49cf1da683fcb150e3
https://doi.org/10.1016/j.jmb.2004.07.013
https://doi.org/10.1016/j.jmb.2004.07.013
Autor:
Jorgina Satrústegui, Luigi Palmieri, Sebastián Cerdán, Ana Villa, Michael J. Runswick, Ferdinando Palmieri, Angelo Vozza, Emanuela Blanco, A. del Arco, John E. Walker, Santiago Cavero
Publikováno v:
Molecular Microbiology. 50:1257-1269
Summary The malate-aspartate NADH shuttle in mammalian cells requires the activity of the mitochondrial aspar- tate-glutamate carrier (AGC). Recently, we identified in man two AGC isoforms, aralar1 and citrin, which are regulated by calcium on the ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76be424c6c944f8c17420804ca9b34c1
https://doi.org/10.1046/j.1365-2958.2003.03742.x
https://doi.org/10.1046/j.1365-2958.2003.03742.x
Autor:
Judy Hirst, John E. Walker, Joe Carroll, Michael J. Runswick, Ian M. Fearnley, Richard J. Shannon
Publikováno v:
Journal of Biological Chemistry. 276:38345-38348
The sequences of 42 subunits of NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria have been described previously. Seven are encoded by mitochondrial DNA, whereas the remaining 35 are nuclear gene products imported into the org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa7717af3a32df20dcec95a77173ba4
https://doi.org/10.1074/jbc.c100444200
https://doi.org/10.1074/jbc.c100444200
Autor:
Ji-Chun Yang, David Neuhaus, Duncan J. Gordon-Smith, Hortense Videler, John E. Walker, Rodrigo J. Carbajo, Michael J. Runswick
Publikováno v:
Journal of Molecular Biology. 308:325-339
Bovine IF1 is a basic, 84 amino acid residue protein that inhibits the hydrolytic action of the F1F0 ATP synthase in mitochondria under anaerobic conditions. Its oligomerization state is dependent on pH. At a pH value below 6.5 it forms an active dim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::778029da98616146c4c2dc27452aa661
https://doi.org/10.1006/jmbi.2001.4570
https://doi.org/10.1006/jmbi.2001.4570
Autor:
Ferdinando Palmieri, Michael J. Runswick, Luigi Palmieri, John E. Walker, Giuseppe Fiermonte, Vincenza Dolce, Mario Ventura
Publikováno v:
Journal of Biological Chemistry. 276:8225-8230
In Saccharomyces cerevisiae, the genes ODC1 and ODC2 encode isoforms of the oxodicarboxylate carrier. They both transport C5-C7 oxodicarboxylates across the inner membranes of mitochondria and are members of the family of mitochondrial carrier protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac0a35868372c74ca4d122d10fc65fc1
https://doi.org/10.1074/jbc.m009607200
https://doi.org/10.1074/jbc.m009607200
Autor:
Gennaro Agrimi, Ferdinando Palmieri, Luigi Palmieri, Michael J. Runswick, Ian M. Fearnley, John E. Walker
Publikováno v:
Journal of Biological Chemistry. 276:1916-1922
The nuclear genome of Saccharomyces cerevisiae encodes 35 members of a family of membrane proteins. Known members transport substrates and products across the inner membranes of mitochondria. We have localized two hitherto unidentified family members
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e822f9f4d276ca791e32bcc786f1f59
https://doi.org/10.1074/jbc.m004332200
https://doi.org/10.1074/jbc.m004332200