Zobrazeno 1 - 10
of 327
pro vyhledávání: '"MICHAEL J. OWEN"'
Autor:
Grace E. Woolway, Sophie E. Legge, Amy J. Lynham, Sophie E. Smart, Leon Hubbard, Ellie R. Daniel, Antonio F. Pardiñas, Valentina Escott-Price, Michael C. O’Donovan, Michael J. Owen, Ian R. Jones, James T. R. Walters
Publikováno v:
Schizophrenia, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract The increasing availability of biobanks is changing the way individuals are identified for genomic research. This study assesses the validity of a self-reported clinical diagnosis of schizophrenia. The study included 1744 clinically-ascertai
Externí odkaz:
https://doaj.org/article/58b31096a7044b28aaa03e23b77da66d
Autor:
Jessica H. Hall, Samuel J. R. A. Chawner, IMAGINE-ID consortium, Jeanne Wolstencroft, David Skuse, Jeremy Hall, Peter Holmans, Michael J. Owen, Marianne B. M. van den Bree
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract A range of rare mutations involving micro-deletion or -duplication of genetic material (copy number variants (CNVs)) have been associated with high neurodevelopmental and psychiatric risk (ND-CNVs). Irritability is frequently observed in chi
Externí odkaz:
https://doaj.org/article/81154eda50754e09b297917153b839e0
Autor:
Josephine E. Haddon, Daniel Titherage, Julia R. Heckenast, Jennifer Carter, Michael J. Owen, Jeremy Hall, Lawrence S. Wilkinson, Matthew W. Jones
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Impaired behavioural flexibility is a core feature of neuropsychiatric disorders and is associated with underlying dysfunction of fronto-striatal circuitry. Reduced dosage of Cyfip1 is a risk factor for neuropsychiatric disorder, as evidence
Externí odkaz:
https://doaj.org/article/ff9feaf84b2d4dadb10bfac41d15a835
Autor:
Jakub Kopal, Kuldeep Kumar, Kimia Shafighi, Karin Saltoun, Claudia Modenato, Clara A. Moreau, Guillaume Huguet, Martineau Jean-Louis, Charles-Olivier Martin, Zohra Saci, Nadine Younis, Elise Douard, Khadije Jizi, Alexis Beauchamp-Chatel, Leila Kushan, Ana I. Silva, Marianne B. M. van den Bree, David E. J. Linden, Michael J. Owen, Jeremy Hall, Sarah Lippé, Bogdan Draganski, Ida E. Sønderby, Ole A. Andreassen, David C. Glahn, Paul M. Thompson, Carrie E. Bearden, Robert Zatorre, Sébastien Jacquemont, Danilo Bzdok
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Asymmetry between the left and right hemisphere is a key feature of brain organization. Hemispheric functional specialization underlies some of the most advanced human-defining cognitive operations, such as articulated language, perspective
Externí odkaz:
https://doaj.org/article/ef8661c3f98b45db8c8b23d96d4aa318
Autor:
Sheng Wang, Belinda Wang, Vanessa Drury, Sam Drake, Nawei Sun, Hasan Alkhairo, Juan Arbelaez, Clif Duhn, Tourette International Collaborative Genetics (TIC Genetics), Vanessa H. Bal, Kate Langley, Joanna Martin, Pieter J. Hoekstra, Andrea Dietrich, Jinchuan Xing, Gary A. Heiman, Jay A. Tischfield, Thomas V. Fernandez, Michael J. Owen, Michael C. O’Donovan, Anita Thapar, Matthew W. State, A. Jeremy Willsey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Autism spectrum disorder (ASD), Tourette syndrome (TS), and attention-deficit/hyperactivity disorder (ADHD) display strong male sex bias, due to a combination of genetic and biological factors, as well as selective ascertainment. While the h
Externí odkaz:
https://doaj.org/article/0f0d828cb9a44cc7a0dc9536fdc3e9b0
Autor:
Siobhan K. Lock, Sophie E. Legge, Djenifer B. Kappel, Isabella R. Willcocks, Marinka Helthuis, John Jansen, James T. R. Walters, Michael J. Owen, Michael C. O’Donovan, Antonio F. Pardiñas
Publikováno v:
Schizophrenia, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract Clozapine is effective at reducing symptoms of treatment-resistant schizophrenia, but it can also induce several adverse outcomes including neutropenia and agranulocytosis. We used linear mixed-effect models and structural equation modelling
Externí odkaz:
https://doaj.org/article/fcf403c7194647e894e0c5a9ae9e3198
Autor:
Yingjie Zhao, Yujue Wang, Lijie Shi, Donna M. McDonald-McGinn, T. Blaine Crowley, Daniel E. McGinn, Oanh T. Tran, Daniella Miller, Jhih-Rong Lin, Elaine Zackai, H. Richard Johnston, Eva W. C. Chow, Jacob A. S. Vorstman, Claudia Vingerhoets, Therese van Amelsvoort, Doron Gothelf, Ann Swillen, Jeroen Breckpot, Joris R. Vermeesch, Stephan Eliez, Maude Schneider, Marianne B. M. van den Bree, Michael J. Owen, Wendy R. Kates, Gabriela M. Repetto, Vandana Shashi, Kelly Schoch, Carrie E. Bearden, M. Cristina Digilio, Marta Unolt, Carolina Putotto, Bruno Marino, Maria Pontillo, Marco Armando, Stefano Vicari, Kathleen Angkustsiri, Linda Campbell, Tiffany Busa, Damian Heine-Suñer, Kieran C. Murphy, Declan Murphy, Sixto García-Miñaúr, Luis Fernández, International 22q11.2 Brain and Behavior Consortium (IBBC), Zhengdong D. Zhang, Elizabeth Goldmuntz, Raquel E. Gur, Beverly S. Emanuel, Deyou Zheng, Christian R. Marshall, Anne S. Bassett, Tao Wang, Bernice E. Morrow
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Congenital heart disease (CHD) affecting the conotruncal region of the heart, occurs in 40–50% of patients with 22q11.2 deletion syndrome (22q11.2DS). This syndrome is a rare disorder with relative genetic homogeneity that can facilitate i
Externí odkaz:
https://doaj.org/article/8c4a618d8f784a9c9f58db40b2e0cf57
Autor:
Jakub Kopal, Kuldeep Kumar, Kimia Shafighi, Karin Saltoun, Claudia Modenato, Clara A. Moreau, Guillaume Huguet, Martineau Jean-Louis, Charles-Olivier Martin, Zohra Saci, Nadine Younis, Elise Douard, Khadije Jizi, Alexis Beauchamp-Chatel, Leila Kushan, Ana I. Silva, Marianne B. M. van den Bree, David E. J. Linden, Michael J. Owen, Jeremy Hall, Sarah Lippé, Bogdan Draganski, Ida E. Sønderby, Ole A. Andreassen, David C. Glahn, Paul M. Thompson, Carrie E. Bearden, Robert Zatorre, Sébastien Jacquemont, Danilo Bzdok
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/0f09dcf7ce654b60bf8094b7c4739668
Autor:
Samuel J. R. A. Chawner, Alexandra Evans, IMAGINE-ID consortium, Nigel Williams, Michael J. Owen, Jeremy Hall, Marianne B. M. van den Bree
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Children with rare neurodevelopmental genetic conditions (ND-GCs) are at high risk for a range of neuropsychiatric conditions. Sleep symptomatology may represent a transdiagnostic risk indicator within this patient group. Here we present dat
Externí odkaz:
https://doaj.org/article/22ab6f6cc0c7413ea74ce08703ef8cd7
Autor:
Samuel J. R. A. Chawner, Amy L. Paine, Matt J. Dunn, Alice Walsh, Poppy Sloane, Megan Thomas, Alexandra Evans, Lucinda Hopkins‐Jones, Siske Struik, IMAGINE‐ID consortium, Jeremy Hall, Jonathan T. Erichsen, Susan R. Leekam, Michael J. Owen, Dale Hay, Marianne B. M. van denBree
Publikováno v:
JCPP Advances, Vol 3, Iss 2, Pp n/a-n/a (2023)
Abstract Background Individuals with 22q11.2 deletion are at considerably increased risk of neurodevelopmental and psychiatric conditions. There have been very few studies investigating how this risk manifests in early childhood and what factors may
Externí odkaz:
https://doaj.org/article/482cdaea28664d24988dbbfae66564be