Zobrazeno 1 - 10
of 149
pro vyhledávání: '"MICHAEL J. JURCZAK"'
Autor:
Raja Gopal Reddy Mooli, Bokai Zhu, Saifur R. Khan, Veerababu Nagati, Kulandaimanuvel Antony Michealraj, Michael J. Jurczak, Sadeesh K. Ramakrishnan
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundThermogenic beige adipocytes, which dissipate energy as heat, are found in neonates and adults. Recent studies show that neonatal beige adipocytes are highly plastic and contribute to >50% of beige adipocytes in adults. Neonatal beige adipo
Externí odkaz:
https://doaj.org/article/c67b53bffb8a42d4b4b60b741db8cbda
Autor:
Bellina A. S. Mushala, Bingxian Xie, Ian J. Sipula, Michael W. Stoner, Dharendra Thapa, Janet R. Manning, Paramesha Bugga, Amber M. Vandevender, Michael J. Jurczak, Iain Scott
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract G-protein coupled receptors (GPCRs) mediate signal transduction from the cellular surface to intracellular metabolic pathways. While the function of many GPCRs has been delineated previously, a significant number require further characteriza
Externí odkaz:
https://doaj.org/article/c29485daa80649a8ab8c95d978674e6e
Autor:
Manling Zhang, Ning Feng, Zishan Peng, Dharendra Thapa, Michael W. Stoner, Janet R. Manning, Charles F. McTiernan, Xue Yang, Michael J. Jurczak, Danielle Guimaraes, Krithika Rao, Sruti Shiva, Brett A. Kaufman, Michael N. Sack, Iain Scott
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106942- (2023)
Summary: General control of amino acid synthesis 5-like 1 (GCN5L1) was previously identified as a key regulator of protein lysine acetylation in mitochondria. Subsequent studies demonstrated that GCN5L1 regulates the acetylation status and activity o
Externí odkaz:
https://doaj.org/article/8909375df39c4b46833adac7bdc0ad27
Autor:
Bingxian Xie, Wesley Ramirez, Amanda M. Mills, Brydie R. Huckestein, Moira Anderson, Martha M. Pangburn, Eric Y. Lang, Steven J. Mullet, Byron W. Chuan, Lanping Guo, Ian Sipula, Christopher P. O'Donnell, Stacy G. Wendell, Iain Scott, Michael J. Jurczak
Publikováno v:
Current Research in Physiology, Vol 5, Iss , Pp 232-239 (2022)
Sodium-glucose co-transporter type 2 (SGLT2) inhibitor therapy to treat type 2 diabetes unexpectedly reduced all-cause mortality and hospitalization due to heart failure in several large-scale clinical trials, and has since been shown to produce simi
Externí odkaz:
https://doaj.org/article/de1807bd131a4a2390d712ba83567563
Autor:
Dharendra Thapa, Bingxian Xie, Bellina A.S. Mushala, Manling Zhang, Janet R. Manning, Paramesha Bugga, Michael W. Stoner, Michael J. Jurczak, Iain Scott
Publikováno v:
Current Research in Physiology, Vol 5, Iss , Pp 55-62 (2022)
Previous studies have shown that treatment with recombinant adropin, a circulating peptide secreted by the liver and brain, restores glucose utilization in the hearts of diet-induced obese mice. This restoration of fuel substrate flexibility, which i
Externí odkaz:
https://doaj.org/article/61011c507a704b55a8aad0c38eff5e3c
Autor:
Bingxian Xie, Anjana Murali, Amber M. Vandevender, Jeffrey Chen, Agustin Gil Silva, Fiona M. Bello, Byron Chuan, Harinath Bahudhanapati, Ian Sipula, Nikolaos Dedousis, Faraaz A. Shah, Christopher P. O’Donnell, Jonathan K. Alder, Michael J. Jurczak
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105569- (2022)
Summary: Growth differentiation factor 15 (GDF15) is a stress-induced secreted protein whose circulating levels are increased in the context of obesity. Recombinant GDF15 reduces body weight and improves glycemia in obese models, which is largely att
Externí odkaz:
https://doaj.org/article/be2159910df74c8da53dc69784e093fc
Autor:
Dharendra Thapa, Paramesha Bugga, Bellina A. S. Mushala, Janet R. Manning, Michael W. Stoner, Brenda McMahon, Xuemei Zeng, Pamela S. Cantrell, Nathan Yates, Bingxian Xie, Lia R. Edmunds, Michael J. Jurczak, Iain Scott
Publikováno v:
Physiological Reports, Vol 10, Iss 15, Pp n/a-n/a (2022)
Abstract Left ventricular diastolic dysfunction is a structural and functional condition that precedes the development of heart failure with preserved ejection fraction (HFpEF). The etiology of diastolic dysfunction includes alterations in fuel subst
Externí odkaz:
https://doaj.org/article/6a55ab8d84e5441b8d4eb92811819642
Autor:
Dong Wang, Robert Hartman, Chao Han, Chao-ming Zhou, Brandon Couch, Matias Malkamaki, Vera Roginskaya, Bennett Van Houten, Steven J. Mullett, Stacy G. Wendell, Michael J. Jurczak, James Kang, Joon Lee, Gwendolyn Sowa, Nam Vo
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-15 (2021)
Abstract Background Intervertebral disc degeneration contributes to low back pain. The avascular intervertebral disc consists of a central hypoxic nucleus pulpous (NP) surrounded by the more oxygenated annulus fibrosus (AF). Lactic acid, an abundant
Externí odkaz:
https://doaj.org/article/c277863dd836412d934d854ba2944040
Autor:
Josepmaria Argemi, Maria U. Latasa, Stephen R. Atkinson, Ilya O. Blokhin, Veronica Massey, Joel P. Gue, Joaquin Cabezas, Juan J. Lozano, Derek Van Booven, Aaron Bell, Sheng Cao, Lawrence A. Vernetti, Juan P. Arab, Meritxell Ventura-Cots, Lia R. Edmunds, Constantino Fondevila, Peter Stärkel, Laurent Dubuquoy, Alexandre Louvet, Gemma Odena, Juan L. Gomez, Tomas Aragon, Jose Altamirano, Juan Caballeria, Michael J. Jurczak, D. Lansing Taylor, Carmen Berasain, Claes Wahlestedt, Satdarshan P. Monga, Marsha Y. Morgan, Pau Sancho-Bru, Philippe Mathurin, Shinji Furuya, Carolin Lackner, Ivan Rusyn, Vijay H. Shah, Mark R. Thursz, Jelena Mann, Matias A. Avila, Ramon Bataller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/65a267dd546740ec9b7190c3e67982ab
Autor:
Josepmaria Argemi, Maria U. Latasa, Stephen R. Atkinson, Ilya O. Blokhin, Veronica Massey, Joel P. Gue, Joaquin Cabezas, Juan J. Lozano, Derek Van Booven, Aaron Bell, Sheng Cao, Lawrence A. Vernetti, Juan P. Arab, Meritxell Ventura-Cots, Lia R. Edmunds, Constantino Fondevila, Peter Stärkel, Laurent Dubuquoy, Alexandre Louvet, Gemma Odena, Juan L. Gomez, Tomas Aragon, Jose Altamirano, Juan Caballeria, Michael J. Jurczak, D. Lansing Taylor, Carmen Berasain, Claes Wahlestedt, Satdarshan P. Monga, Marsha Y. Morgan, Pau Sancho-Bru, Philippe Mathurin, Shinji Furuya, Carolin Lackner, Ivan Rusyn, Vijay H. Shah, Mark R. Thursz, Jelena Mann, Matias A. Avila, Ramon Bataller
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or
Externí odkaz:
https://doaj.org/article/0fb71062dc154a909e1831b9bf41223d