Zobrazeno 1 - 10
of 301
pro vyhledávání: '"MICHAEL C. SANGUINETTI"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The opening and closing of voltage-dependent potassium channels is dependent on a tight coupling between movement of the voltage sensing S4 segments and the activation gate. A specific interaction between intracellular amino- and carboxyl-termini is
Externí odkaz:
https://doaj.org/article/6a5e3708eaaa467c9065cdbdc1b88649
Autor:
Xiaoliang Wang, James S. Trimmer, Walter Stühmer, Michael C. Sanguinetti, Bernardo Rudy, Gail A. Robertson, Luis A. Pardo, Jeanne Nerbonne, David Mckinnon, Michel Lazdunski, Lily Y. Jan, George A. Gutman, Stephan Grissmer, M. Hunter Giese, K. George Chandy, Bernard Attali
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE, vol 2019, iss 4
The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92eb06f5b8beaf76a63bc4917b70ac8
https://escholarship.org/uc/item/1vf1p541
https://escholarship.org/uc/item/1vf1p541
Autor:
Xiaoliang Wang, James S. Trimmer, Walter Stühmer, Michael C. Sanguinetti, Bernardo Rudy, Gail A. Robertson, Luis A. Pardo, Jeanne Nerbonne, David Mckinnon, Michel Lazdunski, Lily Y. Jan, George A. Gutman, Stephan Grissmer, M. Hunter Giese, K. George Chandy, Bernard Attali
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99aca55f8983c389a3f91071d3c86ebc
https://doi.org/10.2218/gtopdb/f81/2023.1
https://doi.org/10.2218/gtopdb/f81/2023.1
Publikováno v:
Biophysical Journal. 122:340a-341a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5938e3436772a8dde89ff294a2d379a
https://doi.org/10.1016/j.bpj.2022.11.1896
https://doi.org/10.1016/j.bpj.2022.11.1896
Publikováno v:
Advances in experimental medicine and biology. 1349
KCNQ1 (K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09a4c1398b527d2454065d373b1773ac
https://pubmed.ncbi.nlm.nih.gov/35138621
https://pubmed.ncbi.nlm.nih.gov/35138621
Publikováno v:
Journal of Pharmacological Sciences, Vol 108, Iss 3, Pp 301-307 (2008)
Block of cardiac hERG K+ channels by the antihistamine terfenadine and the prokinetic agent cisapride is associated with prolonged ventricular repolarization and an increased risk of ventricular arrhythmia. Here, we used a site-directed mutagenesis a
Externí odkaz:
https://doaj.org/article/aa6361ba0fbe4b19a889f266cab50d81
Autor:
Bernardo Rudy, Bernard Attali, Lily Yeh Jan, Xiaoliang Wang, M. Hunter Giese, James S. Trimmer, David McKinnon, George A. Gutman, Jeanne M. Nerbonne, Michel Lazdunski, Stephan Grissmer, Walter Stühmer, K. George Chandy, Gail A. Robertson, Luis A. Pardo, Michael C. Sanguinetti
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c9626dc18faf9d8624389fc9379b08c
https://doi.org/10.2218/gtopdb/f81/2021.3
https://doi.org/10.2218/gtopdb/f81/2021.3
Publikováno v:
Ion Channels in Biophysics and Physiology ISBN: 9789811642531
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d93cb6341e6cb4c2c7fb0ee49586a7d
https://doi.org/10.1007/978-981-16-4254-8_15
https://doi.org/10.1007/978-981-16-4254-8_15
Autor:
Priyanka Garg, Timothy J. Kamp, Rajani Shrestha, Michael C. Sanguinetti, Joseph C. Wu, Vivek Garg
Publikováno v:
Circulation Research. 123:224-243
Life threatening ventricular arrhythmias leading to sudden cardiac death are a major cause of morbidity and mortality. In the absence of structural heart disease, these arrhythmias, especially in the younger population, are often an outcome of geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309f27204f2bb587fcec98356e11492d
https://doi.org/10.1161/circresaha.118.311209
https://doi.org/10.1161/circresaha.118.311209
Autor:
Steven J. Thomson, Wei Wu, Alison Gardner, Michael C. Sanguinetti, Anna Stary-Weinzinger, Eva-Maria Zangerl-Plessl
Publikováno v:
Molecular Pharmacology. 92:437-450
Outward current conducted by human ether-à-go-go–related gene type 1 (hERG1) channels is a major determinant of action potential repolarization in the human ventricle. Ginsenoside 20(S)-Rg3 [Rg3; (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fea2d27e1cb44c2e024bd7a88ec5ef5
https://doi.org/10.1124/mol.117.108886
https://doi.org/10.1124/mol.117.108886