Zobrazeno 1 - 10
of 1 955
pro vyhledávání: '"MHC I"'
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Background In order for cancers to progress, they must evade elimination by CD8 T cells or other immune mechanisms. CD8 T cells recognize and kill tumor cells that display immunogenic tumor peptides bound to MHC I molecules. One of the ways
Externí odkaz:
https://doaj.org/article/4da94f8b8b6c4089b6b46157d67f4054
Autor:
A. Markovska, K. Somers, J. Guillaume, J. Melief, A. P. Mazar, D. M. Schmitt, H. S. Schipper, M. Boes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The prognosis of patients with high-risk neuroblastoma remains poor, partly due to inadequate immune recognition of the tumor. Neuroblastomas display extremely low surface MHC-I, preventing recognition by cytotoxic T lymphocytes (CTLs) and c
Externí odkaz:
https://doaj.org/article/2d883a7222ed4916b7cb4780cb1ff82d
Autor:
Haiyan Dong, Chuangyu Wen, Lu He, Jingdan Zhang, Nanlin Xiang, Liumei Liang, Limei Hu, Weiqian Li, Jiaqi Liu, Mengchen Shi, Yijia Hu, Siyu Chen, Huanliang Liu, Xiangling Yang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Although immune checkpoint inhibitors (ICIs) have revolutionized the landscape of cancer treatment, only a minority of colorectal cancer (CRC) patients respond to them. Enhancing tumor immunogenicity by increasing major histocompa
Externí odkaz:
https://doaj.org/article/a1c66e2cc6294c2fb176311e2e439867
Autor:
Wen Zhang, Yihui Zhai, Ying Cai, Xiang Gong, Yunxuan Jiang, Rong Rong, Chao Zheng, Binyu Zhu, Helen He Zhu, Hao Wang, Yaping Li, Pengcheng Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3218-3231 (2024)
Current cytotoxic T lymphocyte (CTL) activating immunotherapy requires a major histocompatibility complex I (MHC-I)-mediated presentation of tumor-associated antigens, which malfunctions in around half of patients with triple-negative breast cancer (
Externí odkaz:
https://doaj.org/article/eb7defb5eda54de1b7348efd09fcda79
Autor:
Xietao Ye, Yuping Liu, Liangyin Wei, Yeyang Sun, Xiaoran Zhang, Hong Wang, Hong Guo, Xiaoying Qin, Xiaoqi Li, Ding Qu, Jiege Huo, Yan Chen
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Microsatellite‐stable colorectal cancer (MSS‐CRC) exhibits resistance to programmed cell death protein‐1 (PD‐1) therapy. Improving the infiltration and tumor recognition of cytotoxic T‐lymphocytes (CTLs) is a promising strategy, bu
Externí odkaz:
https://doaj.org/article/b263e04093ac4542967b1ea06821e832
Autor:
Ana Laura M. R. Tomiyama, Luciana Politti Cartarozzi, Lilian de Oliveira Coser, Gabriela Bortolança Chiarotto, Alexandre L. R. Oliveira
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/d379d9c35b5b4e3eb77cb21fead20cb4
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Historically inflammation against self was considered autoimmune which stems back to the seminal observations by Ehrlich who described serum factors, now known to be autoantibodies produced by B lineage cells that mediate “horror autotoxicus”. Th
Externí odkaz:
https://doaj.org/article/f06352ab02564fa6a2441cac83b4d998
Publikováno v:
Physiological Reports, Vol 12, Iss 17, Pp n/a-n/a (2024)
Abstract Major histocompatibility complex class I (MHC I) molecules present peptides to CD8+ T‐cells for immunosurveillance of infection and cancer. Recent studies indicate lineage‐specific heterogeneity in MHC I expression. While respiratory dis
Externí odkaz:
https://doaj.org/article/f23d0a14f7c943f5962e8547d191376e
Autor:
Liu Zhu, Li Xin, Muhammad Ali, Sun Qiannan, Zhang Qi, Wang Yang, Wang Yong, Ren Jun, Wang Daorong
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1473-1482 (2024)
Gastric cancer (GC) is a common gastrointestinal system malignancy. PACSIN1 functions as an oncogene in various cancers. This study aims to investigate the potential of PACSIN1 as a target in GC treatment. Gene expression is determined by RT-qPCR, im
Externí odkaz:
https://doaj.org/article/0b962c1cdfa34725bab27ef1b25152f8
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Current cancer therapies often fall short in addressing the complexities of malignancies, underscoring the urgent need for innovative treatment strategies. RNA interference technology, which specifically suppresses gene expression
Externí odkaz:
https://doaj.org/article/c7b511a39ae440e0895e9700fee56886