Zobrazeno 1 - 10
of 3 569
pro vyhledávání: '"MHC, myosin heavy chain"'
Autor:
Yunsuk Choi, Hyunseok Jee
Publikováno v:
The Asian Journal of Kinesiology, Vol 25, Iss 1, Pp 19-26 (2023)
BACKGROUND Various factors-based properties of the skeletal muscle are determined by mechanical stress, chemical stimuli, neuromuscular stimuli, different protein isoforms etc. The properties of the muscle are formed in the process of the balance bet
Externí odkaz:
https://doaj.org/article/a6f93b47aa6a4bbd9e43fae8282eebf0
Autor:
Liangju Kuang, Zhihao Jia, Kun Ho Kim, Meng Deng, Gabrielle Shafer, Paul Lengemann, Naagarajan Narayanan, Victor Bernal-Crespo, Shihuan Kuang
Publikováno v:
Bioactive Materials, Vol 6, Iss 4, Pp 1201-1213 (2021)
Bioactive Materials
Bioactive Materials
Volumetric muscle loss (VML) injuries characterized by critical loss of skeletal muscle tissues result in severe functional impairment. Current treatments involving use of muscle grafts are limited by tissue availability and donor site morbidity. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf482001b2545446cea5faca61842be
http://www.sciencedirect.com/science/article/pii/S2452199X20302632
http://www.sciencedirect.com/science/article/pii/S2452199X20302632
Autor:
Norbert Frey, Lucie Carrier, Franziska Dierck, Frauke Senger, Gabriele Brunke, Christian Kuhn, Nesrin Schmiedel, Ashraf Yusuf Rangrez, Derk Frank, Susanne Hille, Rainer Will, Samuel Sossalla, Maja Menke, Thomas Eschenhagen, Renate Lüllmann-Rauch, Inga Schmidt, Pia Bünger, Claudia Mack
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • FYCO1, a component of the autophagic machinery, is highly expressed in the heart and a potent inducer of cardiomyocyte autophagy. • Loss of FYCO1 in vivo inhibits adaptation to starvation or biomechanical stress
Highlights • FYCO1, a component of the autophagic machinery, is highly expressed in the heart and a potent inducer of cardiomyocyte autophagy. • Loss of FYCO1 in vivo inhibits adaptation to starvation or biomechanical stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8e5357537596081286716a9a13fac0
http://europepmc.org/articles/PMC8093479
http://europepmc.org/articles/PMC8093479
Autor:
Tram Anh Tran, Qing-Jun Zhang, Lei Wang, Christopher Gonzales, Luc Girard, Herman May, Thomas Gillette, Zhi-Ping Liu, Elisabeth D. Martinez
Publikováno v:
The Journal of Biological Chemistry
Hypertrophic/dilated cardiomyopathy, often a prequel to heart failure, is accompanied by maladaptive transcriptional changes that contribute to arrythmias and contractile misfunction. Transgenic mice constitutively expressing high levels of calcineur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112f854788555475bb177a80293d9bd2
https://pubmed.ncbi.nlm.nih.gov/34933013
https://pubmed.ncbi.nlm.nih.gov/34933013
Publikováno v:
Biochemical and Biophysical Research Communications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has the characteristic accessory protein ORF8. Although clinical reports indicate that ORF8 variant strains (Δ382 and L84S variants) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4377fdfc1059189aa39b7797417272
https://pubmed.ncbi.nlm.nih.gov/34062392
https://pubmed.ncbi.nlm.nih.gov/34062392
Autor:
Robin J. Parks, Elias Daher, Radoslav Zinoviev, Jean-Christian Maillet, Michael Phan, Ryan Ard, Stephen H. Gee
Publikováno v:
The Journal of Biological Chemistry
Cells can switch between Rac1 (lamellipodia-based) and RhoA (blebbing-based) migration modes, but the molecular mechanisms regulating this shift are not fully understood. Diacylglycerol kinase ζ (DGKζ), which phosphorylates diacylglycerol to yield
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c1cc51ab6dff8af14a4cc4d83e79bb
https://pubmed.ncbi.nlm.nih.gov/33676892
https://pubmed.ncbi.nlm.nih.gov/33676892
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 621-631 (2021)
Acta Pharmaceutica Sinica B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 621-631 (2021)
Acta Pharmaceutica Sinica B
Natural products generally fall into the biologically relevant chemical space and always possess novel biological activities, thus making them a rich source of lead compounds for new drug discovery. With the recent technological advances, natural pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee67172081a717a9c2539e0b3e363442
https://pubmed.ncbi.nlm.nih.gov/32837872
https://pubmed.ncbi.nlm.nih.gov/32837872
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Nitroxyl (HNO) enhances SR calcium uptake and release in cardiomyocytes, and improves myofilament calcium sensitivity without impacting L-type calcium channel or total SR calcium content. • The effects of the nit
Highlights • Nitroxyl (HNO) enhances SR calcium uptake and release in cardiomyocytes, and improves myofilament calcium sensitivity without impacting L-type calcium channel or total SR calcium content. • The effects of the nit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803069b3001ba958ec9683326d90c4ae
https://doi.org/10.1016/j.jacbts.2018.07.003
https://doi.org/10.1016/j.jacbts.2018.07.003
Autor:
Marion von Frieling-Salewsky, Wolfgang A. Linke, Matthias Bechtel, Andreas Mügge, Dominik Schöne, Susanne Grabbe, Johannes W. Dietrich, Andrea Tannapfel, Justus Strauch, Michael Gotzmann, Cristobal G. dos Remedios
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • The extent of myocardial fibrosis and the degree of isoform-expression and phosphorylation changes in cardiomyocyte titin were unknown in different hemodynamic subgroups of AS, including “paradoxical” low-flow,
Highlights • The extent of myocardial fibrosis and the degree of isoform-expression and phosphorylation changes in cardiomyocyte titin were unknown in different hemodynamic subgroups of AS, including “paradoxical” low-flow,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ec5f5d8be51afa9444d47d8e70ebc7
https://doi.org/10.1016/j.jacbts.2018.02.002
https://doi.org/10.1016/j.jacbts.2018.02.002
Publikováno v:
The Journal of Biological Chemistry
Cardiac myosin is the molecular motor that powers heart contraction by converting chemical energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly regulated to meet the physiological needs of the body. Recent multis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7618af3dcd76ba61655a8927e701d2a4
https://doi.org/10.1016/j.jbc.2021.101297
https://doi.org/10.1016/j.jbc.2021.101297