48Coronary microvascular dysfunction in a porcine model of familial hypercholesterolemia results in perturbations of myocardial oxygen balance at rest and during exercise

Autor: Dirk J. Duncker, MH Laughlin, Doug K Bowles, Daphne Merkus, Shawn B. Bender, Darla L. Tharp, ED Van Deel, V J De Beer

Publikováno v: Cardiovascular Research. 103:S7.2-S7

Purpose. Coronary microvascular dysfunction is increasingly recognized as a contributor to myocardial ischemia in patients with coronary artery disease. Here we investigated perturbations in the regulation of coronary resistance vessel tone and myoca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ad8501243de6eed1709e52fe390dbe1
https://doi.org/10.1093/cvr/cvu080.2

Functional and structural adaptations of the coronary macro- and microvasculature to regular aerobic exercise by activation of physiological, cellular, and molecular mechanisms: ESC Working Group on Coronary Pathophysiology and Microcirculation position paper.

Autor: Koller A; Department of Translational Medicine, Semmelweis University, Budapest, Hungary.; Research Center for Sports Physiology, University of Physical Education, Budapest, Hungary.; Department of Physiology, New York Medical College, Valhalla, NY 10595, USA., Laughlin MH; Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA., Cenko E; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy., de Wit C; Institut für Physiologie, Universitat zu Lübeck, Lübeck, Germany.; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany., Tóth K; Division of Cardiology, 1st Department of Medicine, Medical School, University of Pécs, Pécs, Hungary., Bugiardini R; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy., Trifunovits D; Cardiology Department, Clinical Centre of Serbia and Faculty of Medicine University of Belgrade, Belgrade, Serbia., Vavlukis M; University Clinic for Cardiology, Medical Faculty, Ss' Cyril and Methodius University, Skopje, Republic of Macedonia., Manfrini O; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy., Lelbach A; Departmental Group of Geriatrics, Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest, Dr. Rose Private Hospital, Budapest, Hungary., Dornyei G; Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary., Padro T; Cardiovascular Program-ICCC, Research Institute Hospital Santa Creu i Sant Pau, IIB-Sant Pau, CiberCV-Institute Carlos III, Barcelona, Spain., Badimon L; Cardiovascular Program-ICCC, Research Institute Hospital Santa Creu i Sant Pau, IIB-Sant Pau, CiberCV-Institute Carlos III, Barcelona, Spain., Tousoulis D; First Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece., Gielen S; Department of Cardiology, Angiology, and Intensive Care Medicine, Klinikum Lippe, Detmold, Germany., Duncker DJ; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2022 Jan 29; Vol. 118 (2), pp. 357-371.

Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure.

Autor: Baranowski BJ; Department of Health Sciences and.; Centre for Neuroscience, Brock University, St. Catharines, Ontario, Canada., Allen MD; Department of Physical Medicine and Rehabilitation, School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada., Nyarko JN; Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Rector RS; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.; Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri, USA., Padilla J; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.; Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA., Mousseau DD; Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Rau CD; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Wang Y; Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA., Laughlin MH; Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA., Emter CA; Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA., MacPherson RE; Department of Health Sciences and.; Centre for Neuroscience, Brock University, St. Catharines, Ontario, Canada., Olver TD; Department of Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Publikováno v: JCI insight [JCI Insight] 2021 May 24; Vol. 6 (10). Date of Electronic Publication: 2021 May 24.

Differential impact of severe familial hypercholesterolemia on regional skeletal muscle and organ blood flows during exercise: Effects of PDE5 inhibition.

Autor: Aragonez CG; Biomedical Sciences, University of Missouri, Columbia, Missouri.; Research Service, Harry S Truman Memorial Veterans Hospital, Columbia, Missouri., de Beer VJ; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Tharp DL; Biomedical Sciences, University of Missouri, Columbia, Missouri., Bowles DK; Biomedical Sciences, University of Missouri, Columbia, Missouri.; Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri.; Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri., Laughlin MH; Biomedical Sciences, University of Missouri, Columbia, Missouri.; Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri.; Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri., Merkus D; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Duncker DJ; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Bender SB; Biomedical Sciences, University of Missouri, Columbia, Missouri.; Research Service, Harry S Truman Memorial Veterans Hospital, Columbia, Missouri.; Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri.

Publikováno v: Microcirculation (New York, N.Y. : 1994) [Microcirculation] 2019 Aug; Vol. 26 (6), pp. e12539. Date of Electronic Publication: 2019 Mar 26.

Endurance exercise training does not limit coronary atherosclerosis in familial hypercholesterolemic swine.

Autor: Tharp DL; Department of Biomedical Sciences, University of Missouri, Columbia, Missouri., Masseau I; Department of Clinical Sciences, Université de Montreal, St-Hyacinthe, Canada., Ivey J; Department of Biomedical Sciences, University of Missouri, Columbia, Missouri., Laughlin MH; Department of Biomedical Sciences, University of Missouri, Columbia, Missouri.; Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri., Bowles DK; Department of Biomedical Sciences, University of Missouri, Columbia, Missouri.; Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri.

Publikováno v: Physiological reports [Physiol Rep] 2019 Feb; Vol. 7 (4), pp. e14008.