Zobrazeno 1 - 10
of 189
pro vyhledávání: '"METTL16"'
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Background N6-methyladenosine (m6A) regulates the progression of breast cancer (BC). We aimed to investigate the action and mechanism involved of methyltransferase-like protein 16 (METTL16) in BC growth and metastasis. Methods RT-qPCR, immun
Externí odkaz:
https://doaj.org/article/e7681fb2852643e5af57540bfdcd2c28
Autor:
Meilin Xue, Lei Dong, Honghai Zhang, Yangchan Li, Kangqiang Qiu, Zhicong Zhao, Min Gao, Li Han, Anthony K. N. Chan, Wei Li, Keith Leung, Kitty Wang, Sheela Pangeni Pokharel, Ying Qing, Wei Liu, Xueer Wang, Lili Ren, Hongjie Bi, Lu Yang, Chao Shen, Zhenhua Chen, Laleh Melstrom, Hongzhi Li, Nikolai Timchenko, Xiaolan Deng, Wendong Huang, Steven T. Rosen, Jingyan Tian, Lin Xu, Jiajie Diao, Chun-Wei Chen, Jianjun Chen, Baiyong Shen, Hao Chen, Rui Su
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-24 (2024)
Abstract Background While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains elusive. We aim to c
Externí odkaz:
https://doaj.org/article/b8cac747695b48e59f1516ff7bd9a5a7
Publikováno v:
Open Medicine, Vol 18, Iss 1, Pp 830-46 (2023)
METTL16 is a class-I methyltransferase that is responsible for depositing a vertebrate-conserved S-adenosylmethionine site. Since 2017, there has been a growing body of research focused on METTL16, particularly in the field of structural studies. How
Externí odkaz:
https://doaj.org/article/7001d7118ab843748bb17d93c64e9623
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-15 (2023)
Abstract Background RNA N6-Methyladenosine (m6A) modification is implicated in the progression of human cancers including cholangiocarcinoma (CCA). METTL16 is recently identified as a new RNA methyltransferase responsible for m6A modification, althou
Externí odkaz:
https://doaj.org/article/16aac7b3e78945f38821e921d3dbb114
Autor:
Wei Wei, Zhong-Yuan Zhang, Bin Shi, Yike Cai, Hou-Shun Zhang, Chun-Lei Sun, Yun-Fei Fei, Wen Zhong, Shuang Zhang, Chen Wang, Bing He, Guan-Min Jiang, Hao Wang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-20 (2023)
Abstract Background Glycolysis is the key hallmark of cancer and maintains malignant tumor initiation and progression. The role of N6-methyladenosine (m6A) modification in glycolysis is largely unknown. This study explored the biological function of
Externí odkaz:
https://doaj.org/article/84d0bee25041457392d35c2be4ca04a2
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 7, Pp 5460-5480 (2023)
METTL16, a human m6A RNA methyltransferase, is currently known for its modification of U6 and MAT2A RNAs. Several studies have identified additional RNAs to which METTL16 binds, however whether METTL16 modifies these RNAs is still in question. Moreov
Externí odkaz:
https://doaj.org/article/3374b7caec10447e9f2f5927d39ed5fe
Akademický článek
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Autor:
Kyle D. Mansfield
Publikováno v:
Biology, Vol 13, Iss 6, p 391 (2024)
Methyltransferases are a wide-ranging, yet well-conserved, class of molecules that have been found to modify a wide variety of substrates. Interest in RNA methylation has surged in recent years with the identification of the major eukaryotic mRNA m6A
Externí odkaz:
https://doaj.org/article/00d8269625c44a228c77c4029420ecb2
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1630 (2024)
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and multiple endocrine neoplasia-β (MENβ) are two long noncoding RNAs upregulated in multiple cancers, marking these RNAs as therapeutic targets. While traditional small-molecule and a
Externí odkaz:
https://doaj.org/article/5952f4cc56ce43e09293fec657143cd3
Autor:
Fuming Xie, Yao Zheng, Wen Fu, Bojing Chi, Xianxing Wang, Junfeng Zhang, Jianyou Gu, Jingyang Yin, Qiang Zhou, Shixiang Guo, Lei Cai, Jiali Yang, Songsong Liu, Huaizhi Wang
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/e07d74dfe30b40cc8115a2f9ea3f6416