Zobrazeno 1 - 10
of 140
pro vyhledávání: '"MET oncogene"'
Autor:
Cristina Chiriaco, Chiara Donini, Marco Cortese, Stefano Ughetto, Chiara Modica, Ilaria Martinelli, Alessia Proment, Letizia Vitali, Lara Fontani, Monica Casucci, Paolo Maria Comoglio, Silvia Giordano, Dario Sangiolo, Valeria Leuci, Elisa Vigna
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Aberrant activation of the MET receptor in cancer is sustained by genetic alterations or, more frequently, by transcriptional upregulations. A fraction of MET-amplified or mutated tumors are sensible to MET targeting agents, but t
Externí odkaz:
https://doaj.org/article/22b9bdbe382b4ee3a99b1a5d5a6d5557
Autor:
Ilaria Martinelli, Chiara Modica, Cristina Chiriaco, Cristina Basilico, James M. Hughes, Simona Corso, Silvia Giordano, Paolo M. Comoglio, Elisa Vigna
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-17 (2022)
Abstract Background The tyrosine kinase receptor encoded by the MET oncogene is a major player in cancer. When MET is responsible for the onset and progression of the transformed phenotype (MET-addicted cancers), an efficient block of its oncogenic a
Externí odkaz:
https://doaj.org/article/5300d21aef514f059e95f9114917da72
Publikováno v:
EBioMedicine, Vol 24, Iss C, Pp 34-42 (2017)
The molecular and cellular mechanisms which drive metastatic spread are the topic of constant debate and scientific research due to the potential implications for cancer patients' prognosis. In addition to genetics and environmental factors, mechanic
Externí odkaz:
https://doaj.org/article/9a0f61a5f79249488aeb8147befe00c5
Autor:
Francesca De Bacco, Antonio D'Ambrosio, Elena Casanova, Francesca Orzan, Roberta Neggia, Raffaella Albano, Federica Verginelli, Manuela Cominelli, Pietro L Poliani, Paolo Luraghi, Gigliola Reato, Serena Pellegatta, Gaetano Finocchiaro, Timothy Perera, Elisabetta Garibaldi, Pietro Gabriele, Paolo M Comoglio, Carla Boccaccio
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 5, Pp 550-568 (2016)
Abstract Glioblastoma (GBM) contains stem‐like cells (GSCs) known to be resistant to ionizing radiation and thus responsible for therapeutic failure and rapidly lethal tumor recurrence. It is known that GSC radioresistance relies on efficient activ
Externí odkaz:
https://doaj.org/article/e3a220eeaa804cb09dc87829df92d2bd
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Martina Spilinga, Cristina Basilico, Chiara Modica, Cristina Chiriaco, Paolo M. Comoglio, Elisa Vigna, Tiziana Crepaldi, Simona Gallo
Publikováno v:
Cancers, Vol 12, Iss 3, p 741 (2020)
Cancers
Volume 12
Issue 3
Cancers
Volume 12
Issue 3
The MET oncogene encodes a tyrosine kinase receptor involved in the control of a complex network of biological responses that include protection from apoptosis and stimulation of cell growth during embryogenesis, tissue regeneration, and cancer progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef5ab8233701450e6607da34b88ad7b
https://www.mdpi.com/2072-6694/12/3/741
https://www.mdpi.com/2072-6694/12/3/741
Autor:
Melissa Milan, Cristina Basilico, Martina Olivero, Francesca Zuppini, Elisa Vigna, Chiara Modica
Publikováno v:
Cancers
Volume 13
Issue 14
Cancers, Vol 13, Iss 3519, p 3519 (2021)
Volume 13
Issue 14
Cancers, Vol 13, Iss 3519, p 3519 (2021)
Simple Summary It has been previously shown that activation of the MET receptor by its ligand, the hepatocyte growth factor (HGF), modulates the tumor-stroma cross-talk in models of pancreatic cancer. We now wish to cast light on the molecular mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb700f704d583e3927f88a1100729cce
http://europepmc.org/articles/PMC8305254
http://europepmc.org/articles/PMC8305254
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1988 Apr . 85(8), 2667-2671.
Externí odkaz:
https://www.jstor.org/stable/31496