Zobrazeno 1 - 10
of 32
pro vyhledávání: '"MET Exon 14 Mutation"'
Autor:
François Pinquie, Alain Morel, Benjamin Morvan, Jérémy Sandrini, Olivier Molinier, Alexis B. Cortot, Camille Guguen, Louise-Marie Chevalier
Publikováno v:
Clinical Lung Cancer. 23:e131-e134
Clinical Practice Points • What is already known about this subject? • Resistance mechanisms to osimertinib in T790M positive NSCLC patients are multiple and heterogeneous, combining de novo EGFR alterations (C797S mutation), EGFR-independent mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa5c08897f76a07dea3abfbeb67f079
https://doi.org/10.1016/j.cllc.2021.06.002
https://doi.org/10.1016/j.cllc.2021.06.002
Publikováno v:
Expert Opinion on Therapeutic Targets. 25:249-268
Introduction: The MET gene and its pathway normally plays a crucial role in cell homeostasis, motility, and apoptosis. However, when the MET gene is altered, there is an imbalance toward cell proli...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c592a42dc7d57a452ee9ca95923925
https://doi.org/10.1080/14728222.2021.1925648
https://doi.org/10.1080/14728222.2021.1925648
Autor:
Alexandr O. Ivantsov, Natalia V. Mitiushkina, Tatiana N. Sokolova, Maxim M. Kholmatov, Ilya A. Stepanov, Vladislav I. Tiurin, Ekatherina Sh. Kuligina, Olga S. Yatsuk, Alexandr A. Romanko, Alexandr V. Togo, Alexey M. Belyaev, Evgeny N. Imyanitov
Publikováno v:
Biochimie. 165:267-274
MET exon 14 skipping (exon 14Δ) mutations are associated with tumor sensitivity to a number of tyrosine kinase inhibitors, however clinical testing for MET gene status remains complicated. We developed a simple allele-specific PCR cDNA-based test, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543ba8a545b50007aad6b0a6a846819b
https://doi.org/10.1016/j.biochi.2019.08.014
https://doi.org/10.1016/j.biochi.2019.08.014
Publikováno v:
OncoTargets and Therapy. 12:7323-7328
Background Pulmonary sarcomatoid carcinoma (PSC) is a rare and poorly differentiated type of non-small cell lung cancer (NSCLC) with specific characteristics, which usually presents a challenge in clinical practice. Mesenchymal-epithelial transition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e006071ff92960e3e94474f57c4be6b
https://doi.org/10.2147/ott.s210365
https://doi.org/10.2147/ott.s210365
Autor:
Ruo-Yan Qin, Ling-Yue Zhang, Cheng-Hua Lu, Ling-Shuang Liu, Xiao-Yan Guo, Hong-Hao Xue, Hui-Yong Zhang, Xin-Bei Yuan
Publikováno v:
Medicine
Rationale: Lung cancer is a leading cause of cancer-related mortality worldwide. Currently, targeted therapy has proved highly efficient in the treatment of advanced non-small cell lung cancer (NSCLC). Mesenchymal-epithelial transition factor (MET) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb568f6a38f3f8cb512f435ce025dd86
https://pubmed.ncbi.nlm.nih.gov/33530219
https://pubmed.ncbi.nlm.nih.gov/33530219
Autor:
Jan Braess, Frank Ueckeroth, Diana S.Y. Abdulla, Carina Heydt, Anna-Kristina Eisert, Frank Beckers, Wolfram Meister, Hans-Joachim Kabitz, Johann Lorenzen, Monika Serke, Sabine Merkelbach-Bruse, Sebastian Michels, Jana Fassunke, Florian Kron, A. Meyer, Gabriele Wessling, Lucia Nogova, Bernhard Schaaf, Juliane Sueptitz, Matthias Scheffler, Carsten Schaepers, Sophia Koleczko, Reinhard Buettner, Clemens Schulte, Britta Kaminsky, Richard F. Riedel, Anna Kron, Stefan Krueger, Wolfgang Schulte, Joachim Lorenz, Michael Hamm, Kato Kambartel, Anne M. Schultheis, Christian Grohé, Jürgen Wolf, Lea Ruge, Jutta Kappes, Jens Panse, Niels Reinmuth, Rieke Fischer
Publikováno v:
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 16(4)
Robust data on the outcome of MET-aberrant NSCLC with nontargeted therapies are limited, especially in consideration of the heterogeneity of MET-amplified tumors (METamp).A total of 337 tumor specimens of patients with MET-altered Union for Internati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc23f7e85f05f773a1ed2d4bef0e7c16
https://pubmed.ncbi.nlm.nih.gov/33781436
https://pubmed.ncbi.nlm.nih.gov/33781436
Autor:
Tong-Tong Zhang, Puyuan Xing, Bingning Wang, Lei Guo, Xiuyun Liu, Lixia Chu, Yan Li, Weihua Li, Tian Qiu, Wenting Huang, Jianming Ying, Junling Li
Publikováno v:
Clinical Lung Cancer. 19:e391-e398
Background The MET gene has been recognized as a potential important therapeutic target in non–small-cell lung cancer (NSCLC). We sought to investigate the MET exon 14 mutations in a cohort of Chinese patients with NSCLC. Methods We tested 461 NSCL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f0a6e4cbe4693a1ef9106d09292510
https://doi.org/10.1016/j.cllc.2017.12.006
https://doi.org/10.1016/j.cllc.2017.12.006
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Si-Yang Liu, Qing Zhou, Xu-Chao Zhang, Hong-Fei Gao, Lan-Ying Gou, Yi-Long Wu, Zhong-Yi Dong, Wen-Zhao Zhong, Yang Shao, A. Li, Jian Su, Jin-Ji Yang, Na-Na Lou
Publikováno v:
Journal of Thoracic Oncology. 11:1503-1510
Predictive biomarkers of mesenchymal-to-epithelial transition factor (MET)-targeted therapy remain elusive. Since the discovery of the MNNG HOS Transforming gene (MET) exon 14 mutation, it has been found to have the best potential to become one preci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a09d156c993aa100e774ff667b14193
https://doi.org/10.1016/j.jtho.2016.05.016
https://doi.org/10.1016/j.jtho.2016.05.016
Publikováno v:
Translational Cancer Research. 5:S101-S105
In their recent work published in the Journal of Clinical Oncology, Awad and colleagues presented the interesting results of next-generation sequencing analysis conducted on tissue from 6,376 cancer patients, with a special focus on the description o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555dcb391e731d48e1c5ffc9aa5fb3d2
https://doi.org/10.21037/tcr.2016.04.13
https://doi.org/10.21037/tcr.2016.04.13