An Open-Source Knowledge Graph Ecosystem for the Life Sciences

Autor: Callahan, Tiffany J., Tripodi, Ignacio J., Stefanski, Adrianne L., Cappelletti, Luca, Taneja, Sanya B., Wyrwa, Jordan M., Casiraghi, Elena, Matentzoglu, Nicolas A., Reese, Justin, Silverstein, Jonathan C., Hoyt, Charles Tapley, Boyce, Richard D., Malec, Scott A., Unni, Deepak R., Joachimiak, Marcin P., Robinson, Peter N., Mungall, Christopher J., Cavalleri, Emanuele, Fontana, Tommaso, Valentini, Giorgio, Mesiti, Marco, Gillenwater, Lucas A., Santangelo, Brook, Vasilevsky, Nicole A., Hoehndorf, Robert, Bennett, Tellen D., Ryan, Patrick B., Hripcsak, George, Kahn, Michael G., Bada, Michael, Baumgartner Jr, William A., Hunter, Lawrence E.

Translational research requires data at multiple scales of biological organization. Advancements in sequencing and multi-omics technologies have increased the availability of these data, but researchers face significant integration challenges. Knowle

Externí odkaz: http://arxiv.org/abs/2307.05727

Het-node2vec: second order random walk sampling for heterogeneous multigraphs embedding

Autor: Soto-Gomez, Mauricio, Robinson, Peter, Cano, Carlos, Pashaeibarough, Ali, Cavalleri, Emanuele, Reese, Justin, Mesiti, Marco, Valentini, Giorgio, Casiraghi, Elena

Many real-world problems are naturally modeled as heterogeneous graphs, where nodes and edges represent multiple types of entities and relations. Existing learning models for heterogeneous graph representation usually depend on the computation of spe

Externí odkaz: http://arxiv.org/abs/2101.01425

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An expanded evaluation of protein function prediction methods shows an improvement in accuracy

Autor: Jiang, Yuxiang, Oron, Tal Ronnen, Clark, Wyatt T, Bankapur, Asma R, D'Andrea, Daniel, Lepore, Rosalba, Funk, Christopher S, Kahanda, Indika, Verspoor, Karin M, Ben-Hur, Asa, Koo, Emily, Penfold-Brown, Duncan, Shasha, Dennis, Youngs, Noah, Bonneau, Richard, Lin, Alexandra, Sahraeian, Sayed ME, Martelli, Pier Luigi, Profiti, Giuseppe, Casadio, Rita, Cao, Renzhi, Zhong, Zhaolong, Cheng, Jianlin, Altenhoff, Adrian, Skunca, Nives, Dessimoz, Christophe, Dogan, Tunca, Hakala, Kai, Kaewphan, Suwisa, Mehryary, Farrokh, Salakoski, Tapio, Ginter, Filip, Fang, Hai, Smithers, Ben, Oates, Matt, Gough, Julian, Törönen, Petri, Koskinen, Patrik, Holm, Liisa, Chen, Ching-Tai, Hsu, Wen-Lian, Bryson, Kevin, Cozzetto, Domenico, Minneci, Federico, Jones, David T, Chapman, Samuel, C., Dukka B K., Khan, Ishita K, Kihara, Daisuke, Ofer, Dan, Rappoport, Nadav, Stern, Amos, Cibrian-Uhalte, Elena, Denny, Paul, Foulger, Rebecca E, Hieta, Reija, Legge, Duncan, Lovering, Ruth C, Magrane, Michele, Melidoni, Anna N, Mutowo-Meullenet, Prudence, Pichler, Klemens, Shypitsyna, Aleksandra, Li, Biao, Zakeri, Pooya, ElShal, Sarah, Tranchevent, Léon-Charles, Das, Sayoni, Dawson, Natalie L, Lee, David, Lees, Jonathan G, Sillitoe, Ian, Bhat, Prajwal, Nepusz, Tamás, Romero, Alfonso E, Sasidharan, Rajkumar, Yang, Haixuan, Paccanaro, Alberto, Gillis, Jesse, Sedeño-Cortés, Adriana E, Pavlidis, Paul, Feng, Shou, Cejuela, Juan M, Goldberg, Tatyana, Hamp, Tobias, Richter, Lothar, Salamov, Asaf, Gabaldon, Toni, Marcet-Houben, Marina, Supek, Fran, Gong, Qingtian, Ning, Wei, Zhou, Yuanpeng, Tian, Weidong, Falda, Marco, Fontana, Paolo, Lavezzo, Enrico, Toppo, Stefano, Ferrari, Carlo, Giollo, Manuel, Piovesan, Damiano, Tosatto, Silvio, del Pozo, Angela, Fernández, José M, Maietta, Paolo, Valencia, Alfonso, Tress, Michael L, Benso, Alfredo, Di Carlo, Stefano, Politano, Gianfranco, Savino, Alessandro, Rehman, Hafeez Ur, Re, Matteo, Mesiti, Marco, Valentini, Giorgio, Bargsten, Joachim W, van Dijk, Aalt DJ, Gemovic, Branislava, Glisic, Sanja, Perovic, Vladmir, Veljkovic, Veljko, Veljkovic, Nevena, Almeida-e-Silva, Danillo C, Vencio, Ricardo ZN, Sharan, Malvika, Vogel, Jörg, Kansakar, Lakesh, Zhang, Shanshan, Vucetic, Slobodan, Wang, Zheng, Sternberg, Michael JE, Wass, Mark N, Huntley, Rachael P, Martin, Maria J, O'Donovan, Claire, Robinson, Peter N, Moreau, Yves, Tramontano, Anna, Babbitt, Patricia C, Brenner, Steven E, Linial, Michal, Orengo, Christine A, Rost, Burkhard, Greene, Casey S, Mooney, Sean D, Friedberg, Iddo, Radivojac, Predrag

Background: The increasing volume and variety of genotypic and phenotypic data is a major defining characteristic of modern biomedical sciences. At the same time, the limitations in technology for generating data and the inherently stochastic nature

Externí odkaz: http://arxiv.org/abs/1601.00891

The promises of large language models for protein design and modeling.

Autor: Valentini, Giorgio, Malchiodi, Dario, Gliozzo, Jessica, Mesiti, Marco, Soto-Gomez, Mauricio, Cabri, Alberto, Reese, Justin, Casiraghi, Elena, Robinson, Peter N.

Publikováno v: Frontiers in Bioinformatics; 2023, p1-11, 11p