Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Autor: Alexandre C. Pereira, Jie Yao, Makoto Hirata, Ozren Polasek, Dragana Vuckovic, Mariaelisa Graff, Jing Hua Zhao, Michael R. Brown, Xuan Deng, Barbara V. Howard, Vilmundur Gudnason, Tuomo Rankinen, Yuan Shi, Timo A. Lakka, Ulrich Broeckel, Anuradhani Kasturiratne, Eric Boerwinkle, Charles Kooperberg, Hugues Aschard, Stephen S. Rich, Pamela J. Schreiner, Dan E. Arking, Hans J. Grabe, Ilaria Gandin, Mario Sims, Carl D. Langefeld, Yii-Der Ida Chen, Meian He, W. James Gauderman, Bruce M. Psaty, Kent D. Taylor, Tõnu Esko, Olli T. Raitakari, Saima Afaq, Maik Pietzner, Federica Laguzzi, Dennis O. Mook-Kanamori, Gregory P. Wilson, Xiuqing Guo, Jaspal S. Kooner, David R. Jacobs, Yajuan Wang, Raha Pazoki, Wei Zhao, Andres Metspalu, Mary F. Feitosa, Jost B. Jonas, Tin Aung, Tamara B. Harris, Karin Leander, Nancy L. Pedersen, Charles B. Eaton, Sharon L.R. Kardia, Bernardo L. Horta, Candace M. Kammerer, Terrence Forrester, Alexander P. Reiner, Paul W. Franks, Tanika N. Kelly, Igor Rudan, Ruben N. Eppinga, Melissa A. Richard, Colin A. McKenzie, Christine Williams, Christian Gieger, Joseph H. Lee, Brigitte Kühnel, Christopher P. Nelson, Wen Bin Wei, Antonietta Robino, Anne U. Jackson, E. Shyong Tai, Alisa K. Manning, Lisa R. Yanek, Paul Elliott, Lynne E. Wagenknecht, Ananda R. Wickremasinghe, José Eduardo Krieger, Peter S. Sever, Nora Franceschini, André G. Uitterlinden, Paul M. Ridker, Yun J. Sung, Karen L. Mohlke, Thomas H. Mosley, Nilesh J. Samani, Patricia B. Munroe, Jennifer A. Smith, John M. C. Connell, H. Janaka de Silva, Nicholas Y. Q. Tan, Jian'an Luan, Jennifer E. Huffman, Anna F. Dominiczak, Carsten Oliver Schmidt, Christie M. Ballantyne, Peter J. van der Most, Anuj Goel, Jerome I. Rotter, Amy R. Bentley, Lihua Wang, Rajkumar Dorajoo, Lenore J. Launer, Yechiel Friedlander, Mickaël Canouil, Traci M. Bartz, Thomas Meitinger, Robert A. Scott, Mike A. Nalls, Xueling Sim, Sarah E. Harris, Michael A. Province, Chew-Kiat Heng, Zhe Wang, Norihiro Kato, Evangelos Evangelou, Philippe Froguel, Virginia Fisher, Leslie J. Raffel, Renée de Mutsert, Michele K. Evans, Brenda W.J.H. Penninx, Yih Chung Tham, Tin Louie, Nana Matoba, Lawrence F. Bielak, Andrea R. V. R. Horimoto, Jingmin Liu, Lynda M. Rose, Nona Sotoodehnia, Daniel I. Chasman, Jasmin Divers, John M. Starr, Patricia A. Peyser, Ervin R. Fox, Barry I. Freedman, Megan L. Grove, Jeffrey R. O'Connell, Rob M. van Dam, Michiaki Kubo, Jessica D. Faul, Fang-Chi Hsu, Yize Li, Ilja M. Nolte, Caroline Hayward, Paolo Gasparini, Chiea Chuen Khor, Changwei Li, Xu Chen, James E. Hixson, Patrik K. E. Magnusson, John C. Chambers, Yoichiro Kamatani, Sami Heikkinen, M. Abdullah Said, Martin Farrall, Alena Stančáková, Konstantin Strauch, Albert V. Smith, Yik Ying Teo, Bamidele O. Tayo, Tamar Sofer, Caizheng Yu, Maris Alver, Oscar H. Franco, Yongmei Liu, Ioanna Ntalla, Myriam Fornage, W. Craig Johnson, Dina Vojinovic, William R. Scott, David R. Weir, Yanick Hagemeijer, Raymond Noordam, Mathilde Boissel, Cornelia M. van Duijn, Karen Schwander, Jingzhong Ding, James Scott, Diana van Heemst, Ching-Yu Cheng, Woon-Puay Koh, Jianjun Liu, Kenneth J. Mukamal, Blair H. Smith, Claude Bouchard, Claudia Langenberg, Jingjing Liang, Wei Zheng, Najaf Amin, Ulf de Faire, Bing Yu, Archie Campbell, Kari E. North, Salman M. Tajuddin, Fernando Pires Hartwig, Steve B. Kritchevsky, Tibor V. Varga, Pirjo Komulainen, Hugh Watkins, Johanna Kuusisto, Kurt Lohman, Rozenn N. Lemaitre, Ani Manichaikul, Dabeeru C. Rao, Kenneth Rice, Weihua Zhang, Franco Giulianini, Reedik Mägi, Solomon K. Musani, Wanqing Wen, Nicholas J. Wareham, Charles N. Rotimi, Marzyeh Amini, Rainer Rauramaa, Nicholette D. Palmer, Annette Peters, Neil R Poulter, Benjamin Lehne, Matthias Nauck, Harold Snieder, Donald W. Bowden, M. Arfan Ikram, Lisa de las Fuentes, C. Charles Gu, Xiaofeng Zhu, Markku Laakso, Tuomas O. Kilpeläinen, Ching-Ti Liu, Michael Boehnke, Jin-Fang Chai, Lili Milani, L. Adrienne Cupples, Yuri Milaneschi, Kiang Liu, Stephen Sidney, Alan B. Zonderman, Thomas W. Winkler, Ian J. Deary, Fumihiko Takeuchi, Mary K. Wojczynski, Pim van der Harst, Leo-Pekka Lyytikäinen, Jennifer G. Robinson, Chuan Gao, Xiao-Ou Shu, Diane M. Becker, Mohsen Ghanbari, Alanna C. Morrison, Jian-Min Yuan, Tomohiro Katsuya, Ivana Kolcic, Melanie Waldenberger, Terho Lehtimäki, Heikki A. Koistinen, Erin B. Ware, Ya Xing Wang, Marie Loh, Treva Rice, Qing Duan, Aldi T. Kraja, Sabanayagam Charumathi, Tien Yin Wong, Paul S. de Vries, Yujie Wang, Muhammad Riaz

Publikováno v: American Journal of Epidemiology, 188(6), 1033-1054. Oxford University Press
American Journal of Epidemiology, 188(6), 1033-1054. OXFORD UNIV PRESS INC
American Journal of Epidemiology
American Journal of Epidemiology, 2019, 188 (6), pp.1033-1054. ⟨10.1093/aje/kwz005⟩
American Journal of Epidemiology, Oxford University Press (OUP), 2019, 188 (6), pp.1033-1054. ⟨10.1093/aje/kwz005⟩
2019, ' Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions ', American Journal of Epidemiology . https://doi.org/10.1093/aje/kwz005
American journal of epidemiology, vol 188, iss 6
De Vries, P S, Lifelines Cohort Study, Brown, M R, Bentley, A R, Sung, Y J, Winkler, T W, Ntalla, I, Schwander, K, Kraja, A T, Guo, X, Franceschini, N, Cheng, C Y, Sim, X, Vojinovic, D, Huffman, J E, Musani, S K, Li, C, Feitosa, M F, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Deng, X, Dorajoo, R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Evangelou, E, Graff, M, Alver, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Gandin, I, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, Hartwig, F P, He, M, Horimoto, A R V R, Hsu, F C, Jackson, A U, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Penninx, BWJH & Lifelines Cohort 2019, ' Multiancestry Genome-Wide Association study of lipid levels incorporating gene-alcohol interactions ', American Journal of Epidemiology, vol. 188, no. 6, pp. 1033-1054 . https://doi.org/10.1093/aje/kwz005
Am J Epidemiol
American journal of epidemiology, 188(6), 1033-1054. Oxford University Press

© The Author(s) 2019. A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-Alcohol interactions into a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a600a5a8579ca6101c367851c361758
https://doi.org/10.1093/aje/kwz005

Growing from a few cells: combined effects of initial stochasticity and cell-to-cell variability

Autor: M. S. Suryateja Jammalamadaka, Charles N. Baroud, Antoine Barizien, Gabriel Amselem

Publikováno v: Journal of the Royal Society Interface
Journal of the Royal Society Interface, 2019, 16 (153), pp.20180935. ⟨10.1098/rsif.2018.0935⟩
Journal of the Royal Society Interface, the Royal Society, 2019, 16 (153), pp.20180935. ⟨10.1098/rsif.2018.0935⟩

The growth of a cell population from a large inoculum appears deterministic, although the division process is stochastic at the single-cell level. Microfluidic observations, however, display wide variations in the growth of small populations. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a4066e1f3c6f6f0b0c26a1da57ff22
https://hal-pasteur.archives-ouvertes.fr/pasteur-03328787

Biophysical Studies of the Induced Dimerization of Human VEGF Receptor 1 Binding Domain by Divalent Metals Competing with VEGF-A

Autor: Gaucher, Jean-François, Reille-Seroussi, Marie, Gagey-Eilstein, Nathalie, Broussy, Sylvain, Coric, Pascale, Seijo, Bili, Lascombe, Marie-Bernard, Gautier, Benoît, Liu, Wang-Quing, Huguenot, Florent, Inguimbert, Nicolas, Bouaziz, Serge, Vidal, Michel, Broutin, Isabelle, Lascombe, Marie, Permyakov, Eugene

Publikováno v: PLoS ONE
PLoS ONE, 2016, 11 (12), pp.e0167755. ⟨10.1371/journal.pone.0167755⟩
PLoS ONE, Vol 11, Iss 12, p e0167755 (2016)
PLoS ONE, Public Library of Science, 2016, 11 (12), pp.e0167755. ⟨10.1371/journal.pone.0167755⟩
'PloS One ', vol: 11, pages: e0167755-1-e0167755-23 (2016)

International audience; Angiogenesis is tightly regulated through the binding of vascular endothelial growth factors (VEGFs) to their receptors (VEGFRs). In this context, we showed that human VEGFR1 domain 2 crystallizes in the presence of Zn 2+ , Co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d4dda7ae28b197ecfb3053ed6e2d33
https://hal-univ-perp.archives-ouvertes.fr/hal-01439207/document

Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression

Autor: Ons, Zakraoui, Cezary, Marcinkiewicz, Zohra, Aloui, Houcemeddine, Othman, Renaud, Grépin, Meriam, Haoues, Makram, Essafi, Najet, Srairi-Abid, Ammar, Gasmi, Habib, Karoui, Gilles, Pagès, Khadija, Essafi-Benkhadir

Publikováno v: Molecular Carcinogenesis
Molecular Carcinogenesis, Wiley, 2016, 56, pp.18-35. ⟨10.1002/mc.22470⟩

Lebein, is an heterodimeric disintegrin isolated from Macrovipera lebetina snake venom that was previously characterized as an inhibitor of ADP-induced platelet aggregation. In this study, we investigated the effect of Lebein on the p53-dependent gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0f26039872eae3cfc403bba0d6257ac7
https://hal.archives-ouvertes.fr/hal-01356511

Allium Roseum L. Extract Exerts Potent Suppressive Activities on Chronic Myeloid Leukemia K562 Cell Viability Through the Inhibition of BCR-ABL, PI3K/Akt, and ERK1/2 Pathways and the Abrogation of VEGF Secretion

Autor: Soumaya Souid, H. Karoui, Ingrid Arnault, Makram Essafi, Mohamed Neffati, Ichrak Riahi-Chebbi, Meriam Haoues, Hanen Najjaa, Khadija Essafi-Benkhadir, Jacques Auger

Publikováno v: Nutrition and Cancer
Nutrition and Cancer, Taylor & Francis (Routledge), 2017, 69 (1), pp.117-130. ⟨10.1080/01635581.2017.1248295⟩

International audience; Use of plant extracts, alone or combined to the current chemotherapy as chemosensitizers, has emerged as a promising strategy to overcome tumor drug resistance. Here, we investigated the anticancer activity of Allium roseum L.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8301f04dad4d2ceb5ca0407f07fb6fbe
https://hal-riip.archives-ouvertes.fr/pasteur-01432747