Výsledky vyhledávání - "MESH : Signal Transduction"

IFNγ binding to extracellular matrix prevents fatal systemic toxicity

Autor: Josephine Kemna, Evelyne Gout, Leon Daniau, Jessica Lao, Kristoffer Weißert, Sandra Ammann, Ralf Kühn, Matthias Richter, Christine Molenda, Anje Sporbert, Dario Zocholl, Robert Klopfleisch, Hugues Lortat-Jacob, Peter Aichele, Thomas Kammertoens, Thomas Blankenstein

Publikováno v: Nature Immunology
Nature Immunology, 2023, ⟨10.1038/s41590-023-01420-5⟩
Nature Immunology, 2023, 24 (3), pp.414-422. ⟨10.1038/s41590-023-01420-5⟩

Interferon-γ (IFNγ) is an important mediator of cellular immune responses, but high systemic levels of this cytokine are associated with immunopathology. IFNγ binds to its receptor (IFNγR) and to extracellular matrix (ECM) via four positively cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2795f36be82eab84f706e12f7f7bb4
http://edoc.mdc-berlin.de/23037/1/23037oa.pdf

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The coordinated replication of Vibrio cholerae’s two chromosomes required the acquisition of a unique domain by the RctB initiator

Autor: Fournes, Florian, Niault, Theophile, Czarnecki, Jakub, Tissier-Visconti, Alvise, Mazel, Didier, Val, Marie-Eve

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2021, 49 (19), pp.11119-11133. ⟨10.1093/nar/gkab903⟩
Nucleic Acids Research, Oxford University Press, 2021, 49 (19), pp.11119-11133. ⟨10.1093/nar/gkab903⟩

International audience; Vibrio cholerae, the pathogenic bacterium that causes cholera, has two chromosomes (Chr1, Chr2) that replicate in a well-orchestrated sequence. Chr2 initiation is triggered only after the replication of the crtS site on Chr1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::78989246a70ed6b9797197547822388d
http://europepmc.org/articles/PMC8565311

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Genome-wide whole blood transcriptome profiling in a large European cohort of systemic sclerosis patients

Autor: Zuzanna Makowska, Ricard Cervera, Lorenzo Beretta, László Kovács, Marta E. Alarcón-Riquelme, Guillermo Barturen, Isabel Almeida, Divi Cornec, Javier Martín, Jacques-Olivier Pers, Ellen De Langhe, Nicolas Hunzelmann, Carlo Chizzolini, Maria Gerosa, Martin Kerick, Ralf Lesche, Chiara Bellocchi, Barbara Vigone, Rafaela Ortega Castro

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, 2020, 79 (9), pp.1218-1226. ⟨10.1136/annrheumdis-2020-217116⟩
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2020, 79 (9), pp.1218-1226. ⟨10.1136/annrheumdis-2020-217116⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digital.CSIC. Repositorio Institucional del CSIC

Objectives: The analysis of annotated transcripts from genome-wide expression studies may help to understand the pathogenesis of complex diseases, such as systemic sclerosis (SSc). We performed a whole blood (WB) transcriptome analysis on RNA collect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8074a799258e487dfd1e70971b7098
https://doi.org/10.1136/annrheumdis-2020-217116

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Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease

Autor: Martine Guillermier, Carole Escartin, Océane Guillemaud, Alexis-Pierre Bemelmans, Charlène Joséphine, Gilles Bonvento, Emmanuel Brouillet, Kelly Ceyzériat, Thomas Saint-Georges, Philippe Hantraye, Maria-Angeles Carrillo-de Sauvage, Karine Cambon, Sueva Bernier, Fanny Petit, Lucile Ben Haim, Anne-Sophie Hérard

Publikováno v: Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2020, 90, pp.135-146. ⟨10.1016/j.neurobiolaging.2020.02.010⟩
Neurobiology of Aging, 2020, 90, pp.135-146. ⟨10.1016/j.neurobiolaging.2020.02.010⟩

In Alzheimer disease (AD), astrocytes undergo complex changes and become reactive. The consequences of this reaction are still unclear. To evaluate the net impact of reactive astrocytes in AD, we recently developed viral vectors targeting astrocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b28753aa9921b953676af06fa844c9
https://doi.org/10.1016/j.neurobiolaging.2020.02.010

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Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response

Autor: Tobias Sahr, Pedro Escoll, Christophe Rusniok, Sheryl Bui, Gérard Pehau-Arnaudet, Gregory Lavieu, Carmen Buchrieser

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Nature Communications
Nature Communications, 2022, 13 (1), pp.762. ⟨10.1038/s41467-022-28454-x⟩

Legionella pneumophila is an intracellular bacterial pathogen that can cause a severe form of pneumonia in humans, a phenotype evolved through interactions with aquatic protozoa in the environment. Here, we show that L. pneumophila uses extracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49f43e4ba39cbe29ea18dd8e092f768
https://doi.org/10.1038/s41467-022-28454-x

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Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse

Autor: Christine Gaboriaud, Marie Lorvellec, Véronique Rossi, Chantal Dumestre-Pérard, Nicole M. Thielens

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2022, 13, pp.869720. ⟨10.3389/fimmu.2022.869720⟩

International audience; Our immune system responds to infectious (PAMPs) and tissue damage (DAMPs) signals. The complement system and alarmin High-Mobility Group Box 1 (HMGB1) are two powerful soluble actors of human host defense and immune surveilla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487ecbdd976813bc93ee6a74a6371c0e
https://pubmed.ncbi.nlm.nih.gov/35572583

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Targeting androgen signaling in ILC2s protects from IL-33–driven lung inflammation, independently of KLRG1

Autor: Blanquart, Eve, Mandonnet, Audrey, Mars, Marion, Cenac, Claire, Anesi, Nina, Mercier, Pascale, Audouard, Christophe, Roga, Stephane, Serrano de Almeida, Gilberto, Bevan, Charlotte, Girard, Jean-Philippe, Pelletier, Lucette, Laffont, Sophie, Guéry, Jean-Charles

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, 2022, 149 (1), pp.237-251.e12. ⟨10.1016/j.jaci.2021.04.029⟩
Journal of Allergy and Clinical Immunology, Elsevier, 2021, ⟨10.1016/j.jaci.2021.04.029⟩

International audience; Background: Allergic asthma is more severe and frequent in women than in men. In male mice, androgens negatively control group 2 innate lymphoid cell (ILC2) development and function by yet unknown mechanisms.Objectives: We sou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b00285143bc2806041962f70f839ba74
https://hal.science/hal-03411390/file/1-s2.0-S0091674921007259-main-5.pdf

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Allosteric modulation of ghrelin receptor signaling by lipids

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-23756-y⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here we demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6753e5a97fd1534f0686c5135c0c76a6
https://hal.archives-ouvertes.fr/hal-03357159

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Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus

Autor: Ginés Luengo-Gil, Shivani Reddy, David S. Askew, Laura A. Woollett, Vishukumar Aimanianda, Sarah Sze Wah Wong, José P. Guirao-Abad, Nikita Malev, Christina Grisham, Martin Weichert

Publikováno v: mBio, Vol 12, Iss 5 (2021)
mBio
mBio, 2021, 12 (5), pp.e0273521. ⟨10.1128/mBio.02735-21⟩

International audience; Aspergillus fumigatus is a human-pathogenic mold that extracts nutrients from the environment or from host tissues by secreting hydrolytic enzymes. The ability of A. fumigatus to adjust secretion levels in proportion to demand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3ed62f3472da3d765c7c07f883d03e
https://journals.asm.org/doi/10.1128/mBio.02735-21

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Differential Inhibition of HIV Replication by the 12 Interferon Alpha Subtypes

Autor: Olivia Blake, Arnaud Droit, Alexandre Nicolas, Jérôme Estaquier, Alexandra Tauzin, Armando Espinosa Ortiz, Jacques Dutrieux, Calaiselvy Soundaramourty, Fabrizio Mammano, Charles Joly-Beauparlant

Publikováno v: Journal of Virology
Journal of Virology, 2021, 95 (15), pp.e0231120. ⟨10.1128/JVI.02311-20⟩
J Virol
Journal of Virology, American Society for Microbiology, 2021, 95 (15), pp.e0231120. ⟨10.1128/JVI.02311-20⟩

International audience; Type I interferons (IFNs) are a family of cytokines that represent a first line of defense against virus infections. The 12 different IFN-α subtypes share a receptor on target cells and trigger similar signaling cascades. Sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2043d318193f130e04b6e434b3ee6a22
https://www.hal.inserm.fr/inserm-03451787/document

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