Analysis of fibroblasts from patients with cblC and cblG genetic defects of cobalamin metabolism reveals global dysregulation of alternative splicing

Autor: Jean-Louis Guéant, David Coelho, François Feillet, Natacha Dreumont, Ziad Hassan, Virginie Marchand, Matthias R. Baumgartner, Abderrahim Oussalah, Jean-Michel Camadro, Justine Flayac, David S. Rosenblatt, Charif Rashka, Sébastien Hergalant

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2020, 29 (12), pp.1969-1985. ⟨10.1093/hmg/ddaa027⟩
Human Molecular Genetics, 2020, 29 (12), pp.1969-1985. ⟨10.1093/hmg/ddaa027⟩
Human Molecular Genetics, Oxford University Press (OUP), 2020, ⟨10.1093/hmg/ddaa027⟩
Human Molecular Genetics, Oxford University Press (OUP), 2020, 29 (12), pp.1969-1985. ⟨10.1093/hmg/ddaa027/5739951⟩

International audience; Vitamin B12 or cobalamin (Cbl) metabolism can be affected by genetic defects leading to defective activity of either methylmalonyl-CoA mutase or methionine synthase or both enzymes. Patients usually present with a wide spectru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a35e86a40e26fcc1ed1e42acaa3f2b5
https://hal-cnrs.archives-ouvertes.fr/hal-03100129/document

Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter

Autor: Stephen Cusack, Hélène Malet, Piotr Gerlach, Juan Reguera

Publikováno v: Cell
Cell, Elsevier, 2015, 161 (6), pp.1267-1279. ⟨10.1016/j.cell.2015.05.006⟩
Cell, 2015, 161 (6), pp.1267-1279. ⟨10.1016/j.cell.2015.05.006⟩

Summary Segmented negative-strand RNA virus (sNSV) polymerases transcribe and replicate the viral RNA (vRNA) within a ribonucleoprotein particle (RNP). We present cryo-EM and X-ray structures of, respectively, apo- and vRNA bound La Crosse orthobunya

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcdc23480d949eaab8bddc5c2d5756e

A supramolecular assembly formed by influenza A virus genomic RNA segments

Autor: Roland Marquet, Daniel Thomas, Bruno Lina, Vincent Moules, Annie Cavalier, Catherine Isel, Jean-Paul Rolland, Jean-Christophe Paillart, Emilie Fournier, Jean-Daniel Sirbat, Boris Essere

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2012, 40 (5), pp.2197-209. ⟨10.1093/nar/gkr985⟩
Nucleic Acids Research, Oxford University Press, 2012, 40 (5), pp.2197-209. 〈10.1093/nar/gkr985〉
Nucleic Acids Research, Oxford University Press, 2012, 40 (5), pp.2197-209. ⟨10.1093/nar/gkr985⟩

International audience; The influenza A virus genome consists of eight viral RNAs (vRNAs) that form viral ribonucleoproteins (vRNPs). Even though evidence supporting segment-specific packaging of vRNAs is accumulating, the mechanism ensuring selectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e771704e4f5aa1540c8a3b4307030c
https://doi.org/10.1093/nar/gkr985

Biogenesis and Intranuclear Trafficking of Human Box C/D and H/ACA RNPs

Autor: Jády Be, Fayet E, Patricia Richard, Tamás Kiss, Weber M

Publikováno v: Cold Spring Harbor Symposia on Quantitative Biology
Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory; 1999, 2006, 71, pp.407-17. ⟨10.1101/sqb.2006.71.025⟩

Box C/D and H/ACA snoRNAs represent two abundant groups of small noncoding RNAs. The majority of box C/D and H/ACA snoRNAs function as guide RNAs in the site-specific 2'-O-methylation and pseudouridylation of rRNAs, respectively. The box C/D snoRNAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6650c584244fdfd525b914c6c6393764
https://doi.org/10.1101/sqb.2006.71.025

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

Autor: Alexander Pflug, Thomas Bock, Narin Hengrung, Delphine Guilligay, Darren J. Hart, Kamel El Omari, Florence Baudin, Eric Thierry, Stephen Cusack, Stephanie Gaudon, Martin Beck, Jan Kosinski, Adam Round

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2016, 61 (1), pp.125-37. ⟨10.1016/j.molcel.2015.11.016⟩
Molecular Cell, 2016, 61 (1), pp.125-37. ⟨10.1016/j.molcel.2015.11.016⟩

Summary Influenza virus polymerase transcribes or replicates the segmented RNA genome (vRNA) into respectively viral mRNA or full-length copies and initiates RNA synthesis by binding the conserved 3′ and 5′ vRNA ends (the promoter). In recent str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce963e8b4f5101d9fe04fbcf48f8ca55
https://hal.archives-ouvertes.fr/hal-01430621