Výsledky vyhledávání - "MESH : Receptors, Prolactin"

A Residue Quartet in the Extracellular Domain of the Prolactin Receptor Selectively Controls Mitogen-activated Protein Kinase Signaling

Autor: Sylviane Hoos, Chi Zhang, Gitte W. Haxholm, Patrick England, Birthe B. Kragelund, Isabelle Broutin, Florence Boutillon, Mads Nygaard, Marie Bernadet, Vincent Goffin

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (19), pp.11890-11904. ⟨10.1074/jbc.M115.639096⟩
Journal of Biological Chemistry, 2015, 290 (19), pp.11890-11904. ⟨10.1074/jbc.M115.639096⟩

Cytokine receptors elicit several signaling pathways, but it is poorly understood how they select and discriminate between them. We have scrutinized the prolactin receptor as an archetype model of homodimeric cytokine receptors to address the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8d333304e6a7dd4f047e2215330516
https://doi.org/10.1074/jbc.m115.639096

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Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect

Autor: Diane Rebourcet, Sangeeta Y. Devi, Nadine Binart, Carlos Stocco, Nancy D. Leslie, Geula Gibori, Julia Halperin, Aurora Shehu, Jamie Le, Terry G. Unterman, Shai E. Elizur

Publikováno v: Molecular Endocrinology-Baltimore
Molecular Endocrinology-Baltimore-, Endocrine Society, 2008, 22 (2), pp.513-22. ⟨10.1210/me.2007-0399⟩
Molecular Endocrinology-Baltimore-, Endocrine Society, 2008, 22 (2), pp.513-22. 〈10.1210/me.2007-0399〉

Prolactin (PRL) is a hormone with over 300 biological activities. Although the signaling pathway downstream of the long form of its receptor (RL) has been well characterized, little is known about PRL actions upon activation of the short form (RS). H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73882b1b1111c3c5e7bf1b9fb41da253
https://hal.archives-ouvertes.fr/hal-00475736

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Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity.: PRLR deficiency and beige adipocyte

Autor: Auffret, Julien, Viengchareun, Say, Carre, Nadège, Denis, Raphaël, Magnan, Christophe, Marie, Pierre-Yves, Muscat, Adeline, Fève, Bruno, Lombès, Marc, Binart, Nadine

Publikováno v: FASEB Journal
FASEB Journal, 2012, 26 (9), pp.3728-37. ⟨10.1096/fj.12-204958⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2012, 26 (9), pp.3728-37. ⟨10.1096/fj.12-204958⟩

International audience; Stimulating conversion of white fat to metabolically active adipocytes (beige fat) constitutes a promising strategy against weight gain and its deleterious associated-disorders. We provide direct evidence that prolactin (PRL),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::532ba923a7aea2634c70e20b04daba7c
https://www.hal.inserm.fr/inserm-00696058/file/Figures_Auffret_HAL.pdf

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Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone

Autor: Vincent Goffin, Johannes F. Van Agthoven, Chi Zhang, Isabelle Broutin, Bruno Baron, Bertrand Raynal, Patrick England, Estelle Tallet, Sylviane Hoos

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2010, 404 (1), pp.112-126. ⟨10.1016/j.jmb.2010.09.036⟩
Journal of Molecular Biology, 2010, 404 (1), pp.112-126. ⟨10.1016/j.jmb.2010.09.036⟩

International audience; The most promising approach to targeting the tumor-growth-promoting actions of prolactin (PRL) mediated by its autocrine/paracrine pathway has been the development of specific PRL receptor (PRLR) antagonists. However, the opti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1f0a78dc9095ba62536f979e159d6f
https://pubmed.ncbi.nlm.nih.gov/20875426

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Crystal Structure of an Affinity-matured Prolactin Complexed to Its Dimerized Receptor Reveals the Topology of Hormone Binding Site 2

Autor: Vincent Goffin, Isabelle Broutin, Estelle Tallet, Paul A. Kelly, Patrick England, Johannes F. Van Agthoven, Sylviane Hoos, Jean-Baptiste Jomain, Birthe B. Kragelund, Bertrand Raynal, Arnaud Ducruix

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2010, 285 (11), pp.8422-8433. ⟨10.1074/jbc.M109.089128⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2010, 285 (11), pp.8422-8433. ⟨10.1074/jbc.M109.089128⟩

International audience; We report the first crystal structure of a 1:2 hormone.receptor complex that involves prolactin (PRL) as the ligand, at 3.8-A resolution. Stable ternary complexes were obtained by generating affinity-matured PRL variants harbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05eb2abee8c0ddefa3182cf55ca9ccb
https://hal.science/hal-02519914

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Structural and Thermodynamic Bases for the Design of Pure Prolactin Receptor Antagonists

Autor: Estelle Tallet, Patrick England, Arnaud Ducruix, Johannes F. Van Agthoven, Sylviane Hoos, Birthe B. Kragelund, Vincent Goffin, Isabelle Broutin, Paul A. Kelly, Jean-Baptiste Jomain

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2007, 282 (45), pp.33118-33131. ⟨10.1074/jbc.M704364200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, 282 (45), pp.33118-33131. ⟨10.1074/jbc.M704364200⟩

International audience; Competitive antagonists of the human prolactin (hPRL) receptor are a novel class of molecules of potential therapeutic interest in the context of cancer. We recently developed the pure antagonist Del1-9-G129R-hPRL by deleting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec50072765a3ce9d9ca4db26eb5b649
https://hal.science/hal-02519923

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Effect of PRL on MAPK activation: negative regulatory role of the C-terminal part of the PRL receptor

Autor: Jacqueline Paly, Jean Djiane, Jean-Vianney Barnier, Olivier Goupille, Bernard Guibert

Publikováno v: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2000, 159 (1-2), pp.133-46. ⟨10.1016/S0303-7207(99)00197-5⟩
Molecular and Cellular Endocrinology, Elsevier, 2000, 159, pp.133-146

Prolactin induces cell proliferation and cell differentiation through well-known MAPK Erk, and JAK2/STAT5 pathways depending on the cell line. The aim of the present study was to delineate the functional domains of the PRL receptor involved in PRL in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf57819e0acfee57b0296d307e3bceff
https://hal.archives-ouvertes.fr/hal-00122262

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Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse

Autor: Hélène Buteau, Diane Damotte, J. Barra, B. Lucas, Nicole Brousse, A Camus, Marc Edery, Charles Babinet, Christopher J. Ormandy, Nadine Binart, Paul A. Kelly

Publikováno v: Genes and Development
Genes and Development, Cold Spring Harbor Laboratory Press, 1997, 11 (2), pp.167-178. ⟨10.1101/GAD.11.2.167⟩
Genes and Development, 1997, 11 (2), pp.167-178. ⟨10.1101/GAD.11.2.167⟩

International audience; Mice carrying a germ-line null mutation of the prolactin receptor gene have been produced by gene targeting in embryonic stem cells. Heterozygous females showed almost complete failure of lactation attributable to greatly redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6589044c298422c3743fadc2abdb0253
https://hal.archives-ouvertes.fr/hal-03048903/document

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