Zobrazeno 1 - 10
of 33
pro vyhledávání: '"MESH : RNA Replicase"'
Autor:
Elise Delaforge, Damien Maurin, Sigrid Milles, Nicola Salvi, Martin Blackledge, Stephen Cusack, Darren J. Hart, Malene Ringkjøbing Jensen, Aldo Camacho Zarco, Sissy Kalayil
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-17407-x⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3656. ⟨10.1038/s41467-020-17407-x⟩
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, 2020, 11 (1), pp.3656. ⟨10.1038/s41467-020-17407-x⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-17407-x⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3656. ⟨10.1038/s41467-020-17407-x⟩
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, 2020, 11 (1), pp.3656. ⟨10.1038/s41467-020-17407-x⟩
Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. Adaptive mutants are localised on the C-terminal (627-NLS) domains of the PB2 subunit. In particular, mutation of PB2 residue 627 from E to K rescu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce095ca25613cf9567243b52a9f08146
https://hal.archives-ouvertes.fr/hal-03079958
https://hal.archives-ouvertes.fr/hal-03079958
Publikováno v:
Antiviral Research
Antiviral Research, Elsevier Masson, 2017, 140, pp.25-36. ⟨10.1016/j.antiviral.2016.12.021⟩
Antiviral Research, 2017, 140, pp.25-36. ⟨10.1016/j.antiviral.2016.12.021⟩
Antiviral Research, Elsevier Masson, 2017, 140, pp.25-36. 〈10.1016/j.antiviral.2016.12.021〉
Antiviral Research, Elsevier Masson, 2017, 140, pp.25-36. ⟨10.1016/j.antiviral.2016.12.021⟩
Antiviral Research, 2017, 140, pp.25-36. ⟨10.1016/j.antiviral.2016.12.021⟩
Antiviral Research, Elsevier Masson, 2017, 140, pp.25-36. 〈10.1016/j.antiviral.2016.12.021〉
International audience; In targeting the essential viral RNA-dependent RNA-polymerase (RdRp), nucleotide analogues play a major role in antiviral therapies. In the Flaviviridae family, the hepatitis C virus (HCV) can be eradicated from chronically in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cfcf5ab5748c81f2f90aa5c23349cb
https://hal.archives-ouvertes.fr/hal-01802946
https://hal.archives-ouvertes.fr/hal-01802946
Publikováno v:
Cell
Cell, Elsevier, 2015, 161 (6), pp.1267-1279. ⟨10.1016/j.cell.2015.05.006⟩
Cell, 2015, 161 (6), pp.1267-1279. ⟨10.1016/j.cell.2015.05.006⟩
Cell, Elsevier, 2015, 161 (6), pp.1267-1279. ⟨10.1016/j.cell.2015.05.006⟩
Cell, 2015, 161 (6), pp.1267-1279. ⟨10.1016/j.cell.2015.05.006⟩
Summary Segmented negative-strand RNA virus (sNSV) polymerases transcribe and replicate the viral RNA (vRNA) within a ribonucleoprotein particle (RNP). We present cryo-EM and X-ray structures of, respectively, apo- and vRNA bound La Crosse orthobunya
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcdc23480d949eaab8bddc5c2d5756e
Autor:
Mathy Froeyen, Leen Delang, Stéphanie Beaucourt, Bruno Canard, Ana Theresa Silveira de Morais, Isabelle Imbert, Johan Neyts, Marco Vignuzzi, Hervé Blanc, Pieter Leyssen, Rana Abdelnabi
Publikováno v:
Journal of Virology
Journal of Virology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩
Journal of Virology, American Society for Microbiology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩
Journal of Virology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩
Journal of Virology, American Society for Microbiology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩
Favipiravir (T-705) is a broad-spectrum antiviral agent that has been approved in Japan for the treatment of influenza virus infections. T-705 also inhibits the replication of various RNA viruses, including chikungunya virus (CHIKV). We demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ec8ca79e6936169943b98e6fae68ff
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545928
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545928
Publikováno v:
Antiviral Research
Antiviral Research, Elsevier Masson, 2017, 141, pp.48-61. ⟨10.1016/j.antiviral.2017.02.004⟩
Antiviral Research, 2017, 141, pp.48-61. ⟨10.1016/j.antiviral.2017.02.004⟩
Antiviral Research, Elsevier Masson, 2017, 141, pp.48-61. ⟨10.1016/j.antiviral.2017.02.004⟩
Antiviral Research, 2017, 141, pp.48-61. ⟨10.1016/j.antiviral.2017.02.004⟩
International audience; Filoviruses are important pathogens that cause severe and often fatal hemorrhagic fever in humans, for which no approved vaccines and antiviral treatments are yet available. In an earlier article (Martin et al., Antiviral Rese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760888421eacc35bd3ef4881569bdbed
https://hal.archives-ouvertes.fr/hal-01802809
https://hal.archives-ouvertes.fr/hal-01802809
Publikováno v:
Virus Research
Virus Research, 2017, 234, pp.118-134. ⟨10.1016/j.virusres.2017.01.018⟩
Virus Research, Elsevier, 2017, 234, pp.118-134. ⟨10.1016/j.virusres.2017.01.018⟩
Virus Research, 2017, 234, pp.118-134. ⟨10.1016/j.virusres.2017.01.018⟩
Virus Research, Elsevier, 2017, 234, pp.118-134. ⟨10.1016/j.virusres.2017.01.018⟩
Highlights • Bunyavirus and arenavirus are important public health threats. • Bunyavirus and arenavirus molecular biology, common and differential features. • Implications of LACV L protein structure for understanding viral RNA synthesis. • C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d73b886d3d04cfa3d5af147cf89bb4e
https://hal.science/hal-01802833
https://hal.science/hal-01802833
Autor:
Guillaume Fournier, Chiayn Chiang, Yves Jacob, Andru Tomoiu, Sandie Munier, Caroline Demeret, Nadia Naffakh, Pierre-Olivier Vidalain
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 10, Iss 6, p e1004164 (2014)
PLoS Pathogens, 2014, 10 (6), pp.e1004164. ⟨10.1371/journal.ppat.1004164⟩
PLoS Pathogens, Public Library of Science, 2014, 10 (6), pp.e1004164. ⟨10.1371/journal.ppat.1004164⟩
PLoS Pathogens, Vol 10, Iss 6, p e1004164 (2014)
PLoS Pathogens, 2014, 10 (6), pp.e1004164. ⟨10.1371/journal.ppat.1004164⟩
PLoS Pathogens, Public Library of Science, 2014, 10 (6), pp.e1004164. ⟨10.1371/journal.ppat.1004164⟩
Influenza A viruses are major pathogens in humans and in animals, whose genome consists of eight single-stranded RNA segments of negative polarity. Viral mRNAs are synthesized by the viral RNA-dependent RNA polymerase in the nucleus of infected cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e5f043d8192aa44d66a452577ed54c
http://europepmc.org/articles/PMC4055741
http://europepmc.org/articles/PMC4055741
Autor:
Marco Vignuzzi, Olve B. Peersen, Seth McDonald, Gonzalo Moratorio, Stéphanie Beaucourt, Andrew Block
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (27), pp.13999-14011. ⟨10.1074/jbc.M116.726596⟩
COLIBRI
Universidad de la República
instacron:Universidad de la República
Journal of Biological Chemistry, 2016, 291 (27), pp.13999-14011. ⟨10.1074/jbc.M116.726596⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (27), pp.13999-14011. ⟨10.1074/jbc.M116.726596⟩
COLIBRI
Universidad de la República
instacron:Universidad de la República
Journal of Biological Chemistry, 2016, 291 (27), pp.13999-14011. ⟨10.1074/jbc.M116.726596⟩
International audience; Positive strand RNA viruses replicate via a virally encoded RNA-dependent RNA polymerase (RdRP) that uses a unique palm domain active site closure mechanism to establish the canonical two-metal geometry needed for catalysis. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc79364b4ebc9b544b7b581079965a03
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545937
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545937
Autor:
Alexander Pflug, Thomas Bock, Narin Hengrung, Delphine Guilligay, Darren J. Hart, Kamel El Omari, Florence Baudin, Eric Thierry, Stephen Cusack, Stephanie Gaudon, Martin Beck, Jan Kosinski, Adam Round
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2016, 61 (1), pp.125-37. ⟨10.1016/j.molcel.2015.11.016⟩
Molecular Cell, 2016, 61 (1), pp.125-37. ⟨10.1016/j.molcel.2015.11.016⟩
Molecular Cell, Elsevier, 2016, 61 (1), pp.125-37. ⟨10.1016/j.molcel.2015.11.016⟩
Molecular Cell, 2016, 61 (1), pp.125-37. ⟨10.1016/j.molcel.2015.11.016⟩
Summary Influenza virus polymerase transcribes or replicates the segmented RNA genome (vRNA) into respectively viral mRNA or full-length copies and initiates RNA synthesis by binding the conserved 3′ and 5′ vRNA ends (the promoter). In recent str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce963e8b4f5101d9fe04fbcf48f8ca55
https://hal.archives-ouvertes.fr/hal-01430621
https://hal.archives-ouvertes.fr/hal-01430621
Publikováno v:
Nucleic acids research, Oxford : Oxford University Press, 2016, Vol. 44, no 10, p. 4551-4564
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2016, 44 (10), pp.4551-4564. ⟨10.1093/nar/gkw322⟩
Nucleic Acids Research, 2016, 44 (10), pp.4551-4564. ⟨10.1093/nar/gkw322⟩
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2016, 44 (10), pp.4551-4564. ⟨10.1093/nar/gkw322⟩
Nucleic Acids Research, 2016, 44 (10), pp.4551-4564. ⟨10.1093/nar/gkw322⟩
International audience; Genomic DNA replication is a complex process that involves multiple proteins. Cellular DNA replication systems are broadly classified into only two types, bacterial and archaeo-eukaryotic. In contrast, double-stranded (ds) DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4723cebab3474f724ab2c616d754e61
https://repository.vu.lt/VU:ELABAPDB19542979&prefLang=en_US
https://repository.vu.lt/VU:ELABAPDB19542979&prefLang=en_US