Le gène MAPT est méthylé différentiellement dans le cerveau dans la paralysie supranucléaire progressive

Autor: HUIN, Vincent, Deramecourt, Vincent, Caparros-Lefebvre, Dominique, Maurage, Claude-Alain, Duyckaerts, Charles, Kovari, Eniko, Pasquier, Florence, Buée-Scherrer, Valérie, Labreuche, Julien, Behal, Hélène, Buée, Luc, Dhaenens, Claire-Marie, Sablonnière, Bernard

Publikováno v: Movement Disorders, Vol. 31, No 12 (2016) pp. 1883-1890
Movement Disorders
Movement Disorders, Wiley, 2016, 31 (12), pp.1883-1890. ⟨10.1002/mds.26820⟩

International audience; Background: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease causing parkinsonian symptoms. Altered DNA methylation of the microtubule-associated protein tau gene correlates with the expression changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cf2cfca09d6c3801c9d118c5299515
http://arxiv.org/abs/2011.10447

Tetanus Toxin Synthesis is Under the Control of A Complex Network of Regulatory Genes in Clostridium tetani

Autor: Lucile Plourde, Vincent Colombié, Olivier Gorgette, Dominique Garnier, Cecile Deneve, Diana Chapeton-Montes, Christine Schmitt, Holger Brüggemann, Catherine Thouvenot, Fabien Barbirato, Sandy Demay, Michel R. Popoff, Georges Michel Haustant

Publikováno v: Chapeton-Montes, D, Plourde, L, Deneve, C, Garnier, D, Barbirato, F, Colombié, V, Demay, S, Haustant, G, Gorgette, O, Schmitt, C, Thouvenot, C, Brüggemann, H & Popoff, M R 2020, ' Tetanus Toxin Synthesis is Under the Control of A Complex Network of Regulatory Genes in Clostridium tetani ', Toxins, vol. 12, no. 5, 328 . https://doi.org/10.3390/toxins12050328
Toxins
Toxins, MDPI, 2020, 12 (5), pp.328. ⟨10.3390/toxins12050328⟩
Volume 12
Issue 5
Toxins, Vol 12, Iss 328, p 328 (2020)
Toxins, 2020, 12 (5), pp.328. ⟨10.3390/toxins12050328⟩

Clostridium tetani produces a potent neurotoxin, the tetanus toxin (TeNT), which is responsible for an often-fatal neurological disease (tetanus) characterized by spastic paralysis. Prevention is efficiently acquired by vaccination with the TeNT toxo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c9add8fb7e6507c1f40d5a792d247f
https://pure.au.dk/portal/da/publications/tetanus-toxin-synthesis-is-under-the-control-of-a-complex-network-of-regulatory-genes-in-clostridium-tetani(3a664e86-641a-4ce2-931f-5f9635ef8ac9).html

Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods

Autor: Eric A. Miska, Samuel H. Lewis, Laura Ross, Francis M. Jiggins, Richard Cordaux, Stevie A. Bain, Stephen A. Smith, Eleni Pahita, Peter Sarkies, Boris Lenhard

Publikováno v: e1008864
PLoS Genetics
PLoS Genetics, Public Library of Science, 2020, 16 (6), pp.e1008864. ⟨10.1371/journal.pgen.1008864⟩
PLOS Genetics
Lewis, S H, Ross, L, Bain, S A, Pahita, E, Smith, S A, Cordaux, R, Miska, E A, Lenhard, B, Jiggins, F M & Sarkies, P 2020, ' Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods ', PLoS Genetics, vol. 16, no. 6, e1008864 . https://doi.org/10.1371/journal.pgen.1008864
PLoS Genetics, Vol 16, Iss 6, p e1008864 (2020)

Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals, methylation controls transposable elements and regulates the promoters of genes. In insects, DNA m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ca574e0ec9e466824a7fab2012f5c9
https://hdl.handle.net/11250/2762534

A genetic variant controls interferon-β gene expression in human myeloid cells by preventing C/EBP-β binding on a conserved enhancer

Autor: Didier Busso, Lluis Quintana-Murci, Paul-Henri Romeo, Juliette Hamroune, Anaïs Assouvie, Germain Rousselet, Maxime Rotival

Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, 2020, 16 (11), pp.e1009090. ⟨10.1371/journal.pgen.1009090⟩
PLoS Genetics, Vol 16, Iss 11, p e1009090 (2020)
PLoS Genetics, 2020, 16 (11), pp.e1009090. ⟨10.1371/journal.pgen.1009090⟩

Interferon β (IFN-β) is a cytokine that induces a global antiviral proteome, and regulates the adaptive immune response to infections and tumors. Its effects strongly depend on its level and timing of expression. Therefore, the transcription of its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a80ae8119a6c1f941629a571c21e1be
https://pubmed.ncbi.nlm.nih.gov/33147208

Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

Autor: Shahragim Tajbakhsh, Wolf Reik, Brendan Evano, Thomas M. Stubbs, Pierre-Henri Commere, Marc Jan Bonder, Stephen J. Clark, Simon Andrews, Irene Hernando-Herraez

Publikováno v: Nature Communications
Nature Communications, 2019, 10 (1), pp.4361. ⟨10.1038/s41467-019-12293-4⟩
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.4361. ⟨10.1038/s41467-019-12293-4⟩

Age-related tissue alterations have been associated with a decline in stem cell number and function. Although increased cell-to-cell variability in transcription or epigenetic marks has been proposed to be a major hallmark of ageing, little is known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8102a8ae6840250a67fc2cc2bb49001d
https://hal-pasteur.archives-ouvertes.fr/pasteur-03105560/document