Truncation of PITX2 differentially affects its activity on physiological targets

Autor: Véronique Vieira, Maurice Menasche, James P. Herman, Thierry Brue, Alain Enjalbert, Marc Abitbol, Marie-Helene Quentien, Jean-Louis Dufier

Publikováno v: Journal of Molecular Endocrinology
Journal of Molecular Endocrinology, BioScientifica, 2011, 46 (1), pp.9-19. ⟨10.1677/JME-10-0063⟩
Journal of Molecular Endocrinology, BioScientifica, 2011, 46 (1), pp.9-19. 〈10.1677/JME-10-0063〉
Journal of Molecular Endocrinology, 2011, 46 (1), pp.9-19. ⟨10.1677/JME-10-0063⟩

International audience; The bicoid-like transcription factor PITX2 has been previously described to interact with the pituitary-specific POU homeodomain factor POU1F1 (human ortholog of PIT-1) to achieve cell-specific expression of prolactin (PRL) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6b1be11273329bd0e19440e69dbc25
https://doi.org/10.1677/jme-10-0063

Rapid diagnostic protocol for patients with chest pain

Autor: Charles Groizard, Sarah Derian, Alexis Descatha

Publikováno v: Lancet
Lancet, Elsevier, 2011, 378 (9789), 398; author reply 398-9. ⟨10.1016/S0140-6736(11)61205-1⟩
The Lancet
The Lancet, Elsevier, 2011, 378 (9789), 398; author reply 398-9. ⟨10.1016/S0140-6736(11)61205-1⟩

International audience; no abstract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c7a4a88e08c0de82b0f438b34c283e
https://www.hal.inserm.fr/inserm-00679724/document

New developments on the galactopoietic role of prolactin in dairy ruminants

Autor: Frederic Dessauge, Pierre Lacasse, Vanessa Lollivier, S. Ollier, Rupert M. Bruckmaier, Marion Boutinaud

Publikováno v: 7. International Congress on Farm Animal Endocrinology (ICFAE), Bern, CHE, 2011-08-24-2011-08-26
7. International Congress on Farm Animal Endocrinology (ICFAE)
7. International Congress on Farm Animal Endocrinology (ICFAE), Aug 2011, Bern, Switzerland
Domestic Animal Endocrinology
7th International Conference on Farm Animal Endocrinology
Domestic Animal Endocrinology, Elsevier, 2012, 43 (2), pp.154-60. ⟨10.1016/j.domaniend.2011.12.007⟩

In most mammals, prolactin (PRL) is essential for maintaining lactation and its suppression strongly inhibits lactation. However, the involvement of PRL in the control of ruminant lactation is less clear because inconsistent effects on milk yield hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67c2a36a0ab0a45eb5807ada83c820f
http://prodinra.inra.fr/record/264845

Crystal Structure of an Affinity-matured Prolactin Complexed to Its Dimerized Receptor Reveals the Topology of Hormone Binding Site 2

Autor: Vincent Goffin, Isabelle Broutin, Estelle Tallet, Paul A. Kelly, Patrick England, Johannes F. Van Agthoven, Sylviane Hoos, Jean-Baptiste Jomain, Birthe B. Kragelund, Bertrand Raynal, Arnaud Ducruix

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2010, 285 (11), pp.8422-8433. ⟨10.1074/jbc.M109.089128⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2010, 285 (11), pp.8422-8433. ⟨10.1074/jbc.M109.089128⟩

International audience; We report the first crystal structure of a 1:2 hormone.receptor complex that involves prolactin (PRL) as the ligand, at 3.8-A resolution. Stable ternary complexes were obtained by generating affinity-matured PRL variants harbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05eb2abee8c0ddefa3182cf55ca9ccb
https://hal.science/hal-02519914

Effect of PRL on MAPK activation: negative regulatory role of the C-terminal part of the PRL receptor

Autor: Jacqueline Paly, Jean Djiane, Jean-Vianney Barnier, Olivier Goupille, Bernard Guibert

Publikováno v: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2000, 159 (1-2), pp.133-46. ⟨10.1016/S0303-7207(99)00197-5⟩
Molecular and Cellular Endocrinology, Elsevier, 2000, 159, pp.133-146

Prolactin induces cell proliferation and cell differentiation through well-known MAPK Erk, and JAK2/STAT5 pathways depending on the cell line. The aim of the present study was to delineate the functional domains of the PRL receptor involved in PRL in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf57819e0acfee57b0296d307e3bceff
https://hal.archives-ouvertes.fr/hal-00122262