Výsledky vyhledávání - "MESH : Phosphorylation"

Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease

Autor: Martine Guillermier, Carole Escartin, Océane Guillemaud, Alexis-Pierre Bemelmans, Charlène Joséphine, Gilles Bonvento, Emmanuel Brouillet, Kelly Ceyzériat, Thomas Saint-Georges, Philippe Hantraye, Maria-Angeles Carrillo-de Sauvage, Karine Cambon, Sueva Bernier, Fanny Petit, Lucile Ben Haim, Anne-Sophie Hérard

Publikováno v: Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2020, 90, pp.135-146. ⟨10.1016/j.neurobiolaging.2020.02.010⟩
Neurobiology of Aging, 2020, 90, pp.135-146. ⟨10.1016/j.neurobiolaging.2020.02.010⟩

In Alzheimer disease (AD), astrocytes undergo complex changes and become reactive. The consequences of this reaction are still unclear. To evaluate the net impact of reactive astrocytes in AD, we recently developed viral vectors targeting astrocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b28753aa9921b953676af06fa844c9
https://doi.org/10.1016/j.neurobiolaging.2020.02.010

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No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1

Autor: Sébastien Chamois, Claire Torchet, Rénette Saint-Fort, Julien Henri, Lionel Benard, Albertas Navickas

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.122. ⟨10.1038/s41467-019-13991-9⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-019-13991-9⟩

The No-Go Decay (NGD) mRNA surveillance pathway degrades mRNAs containing stacks of stalled ribosomes. Although an endoribonuclease has been proposed to initiate cleavages upstream of the stall sequence, the production of two RNA fragments resulting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fcd3cb7f63cb2b735842b2f2feb2500
https://doaj.org/article/a8fd17d189c847329043a5bf30ab1d19

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Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome

Publikováno v: Nature Communications
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4304. ⟨10.1038/s41467-021-24319-x⟩
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1265af7d15b7294e224b6f8386b92398
https://doi.org/10.1038/s41467-021-24319-x

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G protein‐coupled receptors can control the Hippo/YAP pathway through Gq signaling

Autor: Zindel, Diana, Mensat, Patrick, Vol, Claire, Homayed, Zeinab, Charrier-Savournin, Fabienne, Trinquet, Eric, Banères, Jean-Louis, Pin, Jean-Philippe, Pannequin, Julie, Roux, Thomas, Dupuis, Elodie, Prézeau, Laurent, Charrier‐Savournin, Fabienne, Banères, Jean‐Louis, Pin, Jean‐Philippe

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2021, 35 (7), pp.e21668. ⟨10.1096/fj.202002159R⟩
FASEB Journal, 2021, 35 (7), pp.e21668. ⟨10.1096/fj.202002159R⟩

International audience; The Hippo pathway is an evolutionarily conserved kinase cascade involved in the control of tissue homeostasis, cellular differentiation, proliferation, and organ size, and is regulated by cell-cell contact, apical cell polarit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d116edd5ecc7a3517e908ffca203be02
https://hal.archives-ouvertes.fr/hal-03382626

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PERIOD-controlled deadenylation of the timeless transcript in the Drosophila circadian clock

Autor: Eric Jacquet, Christian Papin, Prishila Ponien, Elisabeth Chélot, François Rouyer, Béatrice Martin, Brigitte Grima

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (12), pp.5721-5726. ⟨10.1073/pnas.1814418116⟩

Significance Circadian oscillators rely on transcriptional negative feedback loops. In Drosophila , the key transcriptional repressor PERIOD (PER) slowly accumulates during the night under the control of its partner TIMELESS (TIM). A large number of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38acccc1962b25b5234effd92def4be0
https://doi.org/10.1073/pnas.1814418116

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Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Cell Biology, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
research@ua; Vol 11 (2020); 49
research@ua; vol. 11 (2020); 49
Digital.CSIC. Repositorio Institucional del CSIC
instname

Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental changes in the early embryo. PSCs can be stabilized in the naive state by blocking extracellular differentiation stimuli, particularly FGF–MEK signallin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e6662dbd5d60ba17897bdaeae5b24d
https://hal.archives-ouvertes.fr/hal-03234133

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The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Autor: Yiming Cai, Maya Modak, Sebastian Weigang, Emmie de Wit, Jean K. Lim, Alistair Dunham, Benjamin J. Polacco, Qiongyu Li, Svenja Ulferts, Gwendolyn M. Jang, Aurelien Dugourd, David E. Gordon, Jeffrey Z. Guo, Kirsten Obernier, Sophia Bouhaddou, Elizabeth R. Fischer, Anna Gaulton, Jason C.J. Chang, Bjoern Meyer, Diego Quintero, Julian Knerr, Trupti Patil, Emma J. Manners, Michael C. O’Neal, Monita Muralidharan, Joseph Hiatt, Ajda Rojc, James E. Melnyk, Tanja Kortemme, Benjamin R. tenOever, Thomas Vallet, Rémy Robinot, Cassandra Koh, Benjamin E. Nilsson-Payant, Ruth Hüttenhain, Saker Klippsten, Alicia L. Richards, Eloy Felix, Brian K. Shoichet, Beril Tutuncuoglu, Danielle L. Swaney, Veronica V. Rezelj, Jeffery R. Johnson, Margaret Soucheray, Marisa Goff, R. Dyche Mullins, Kris M. White, Erica Stevenson, Jyoti Batra, Christopher J.P. Mathy, Yuan Zhou, Minkyu Kim, Marco Vignuzzi, Claudia Hernandez-Armenta, Kevan M. Shokat, Julio Saez-Rodriguez, Jacqueline M. Fabius, Timothy McBride, Adolfo García-Sastre, Quang Dinh Tran, Alexandra Hardy, Elena Moreno, Alberto Valdeolivas, Mehdi Bouhaddou, Andrew R. Leach, Melanie Ott, Georg Kochs, Pedro Beltrao, Jiewei Xu, Robyn M. Kaake, Merve Cakir, Ying Shi, Nevan J. Krogan, Lisa Miorin, Danish Memon, David J. Broadhurst, Miguel Correa Marrero, Robert Grosse

Publikováno v: Cell
Cell, vol 182, iss 3
Cell, Elsevier, 2020, 182, pp.685-712.e19. ⟨10.1016/j.cell.2020.06.034⟩
Cell, 2020, 182 (3), pp.685-712.e19. ⟨10.1016/j.cell.2020.06.034⟩

Summary The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3a4ccf1bdc8c22239cad9f79ccc506
http://europepmc.org/articles/PMC7321036

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Modulation of glycine receptor single-channel conductance by intracellular phosphorylation

Autor: Gonzalo E. Yévenes, Gustavo Moraga-Cid, Hanns Ulrich Zeilhofer, Patricio A. Castro, Jorge Fuentealba, Luis G. Aguayo, Carola Muñoz-Montesino, Anggelo Sazo, Carlos F. Burgos, Cesar O. Lara, Pierre-Jean Corringer, Leonardo Guzmán, Ana M Marileo, Victoria P San Martín, Braulio Muñoz

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.4804. ⟨10.1038/s41598-020-61677-w⟩
Scientific Reports, 10 (1)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, 2020, 10 (1), pp.4804. ⟨10.1038/s41598-020-61677-w⟩

Glycine receptors (GlyRs) are anion-permeable pentameric ligand-gated ion channels (pLGICs). The GlyR activation is critical for the control of key neurophysiological functions, such as motor coordination, respiratory control, muscle tone and pain pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf6c5d38aaddaada9261c30c262652d
https://doi.org/10.1038/s41598-020-61677-w

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Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation

Autor: Ahmed Alshawi, Loranne Agius, Marc Foretz, Benoit Viollet, Silvia Marin, Natasha S. Adam-Primus, Shruti S. Chachra, Ziad H. Al-Oanzi, Tabassum Moonira, Marta Cascante, Catherine Arden, Brian E. Ford

Publikováno v: The Journal of Biological Chemistry
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (10), pp.3330-3346. ⟨10.1074/jbc.ra120.012533⟩

International audience; The chronic effects of metformin on liver gluconeogenesisinvolve repression of theG6pcgene, which is regulated by thecarbohydrate-response element–binding protein throughraised cellular intermediates of glucose metabolism. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f735b9110a996135298766fd5778907
https://pubmed.ncbi.nlm.nih.gov/31974165

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