Impact of pharmacogenetics on variability in exposure to oral vinorelbine among pediatric patients: a model-based population pharmacokinetic analysis

Autor: Mourad Hamimed, Pierre Leblond, Aurélie Dumont, Florence Gattacceca, Emmanuelle Tresch-Bruneel, Alicia Probst, Pascal Chastagner, Anne Pagnier, Emilie De Carli, Natacha Entz-Werlé, Jacques Grill, Isabelle Aerts, Didier Frappaz, Anne-Isabelle Bertozzi-Salamon, Caroline Solas, Nicolas André, Joseph Ciccolini

Publikováno v: Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology, 2022, 90 (1), pp.29-44. ⟨10.1007/s00280-022-04446-y⟩

Better understanding of pharmacokinetics of oral vinorelbine (VNR) in children would help predicting drug exposure and, beyond, clinical outcome. Here, we have characterized the population pharmacokinetics of oral VNR and studied the factors likely t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f041b62efb1624a2457276d3287b5aa4
https://pubmed.ncbi.nlm.nih.gov/35751658

Pharmacist’s attitudes and knowledge of pharmacogenomics and the factors that may predict future engagement

Autor: Megan E. Hundertmark, Stephen C. Waring, David D. Stenehjem, Danielle A. MacDonald, David D. Sperl, Ann Yapel, Jacob T. Brown

Publikováno v: Pharmacy Practice, Vol 18, Iss 3, p 2008 (2020)
Pharmacy Practice

Background: While pharmacists are well positioned to implement pharmacogenomic testing in healthcare systems, uptake has been limited. Objective: The primary objective of this survey was to determine how post-graduate education and training influence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb022b85f3da9d34477ef88680ad53a
https://doi.org/10.18549/pharmpract.2020.3.2008

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

Autor: Dan M. Roden, Marylyn D. Ritchie, Jae-Gook Shin, Braxton D. Mitchell, Teri E. Klein, Gian Franco Gensini, Jurriën M. ten Berg, Pierre Fontana, Lene Holmvang, Israel Fernandez-Cadenas, Willibald Hochholzer, Stefan Winter, Tabassome Simon, Ruth E. Pakyz, Paul A. Gurbel, Richard B. Horenstein, Ming-Shien Wen, Tobias Geisler, John H. Cleator, Marco Valgimigli, Ho-Sook Kim, Jean-Sébastien Hulot, Jolanta M. Siller-Matula, Dietmar Trenk, Gianluca Campo, Michiaki Kubo, Elke Schaeffeler, Nadia Paarup Dridi, Ming Ta Michael Lee, Li Gong, Joshua P. Lewis, Jean-Pierre Déry, Rossella Marcucci, Kiyuk Chang, Meinrad Gawaz, Kevin P. Bliden, Alan R. Shuldiner, Daniel Aradi, Thomas O. Bergmeijer, Betti Giusti, Russ B. Altman, Dimitrios Alexopoulos, Matthias Schwab, Ryan Whaley, Jean-Luc Reny, Joan Montaner, Eun Young Kim

Publikováno v: American Heart Journal
American Heart Journal, Vol. 198 (2018) pp. 152-159
American Heart Journal, Elsevier, 2018, 198, pp.152-159. ⟨10.1016/j.ahj.2017.12.010⟩

RATIONALE: The P2Y(12) receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention or ischemic stroke. Platelet inhibition by clopidogrel shows wide inter-patient variability and high on-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3d513bc2b922f707381d003c3eea76
https://pubmed.ncbi.nlm.nih.gov/29653637

Suicidalité sous antidépresseurs : aspects cliniques et étude cas-témoin pharmacogénétique

Autor: Voegeli Planquette, Géraldine

Publikováno v: Médecine humaine et pathologie. 2015

Antidepressant-worsening suicidal ideation (AWSI) is a rare but serious phenomenon. Multiple hypotheses have been suggested to explain AWSI: pharmacokinetic profile of antidepressants (AD), mixed states mistaken for unipolar depressive episodes, para

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f7110a992511fe02157299c10265ee84
https://dumas.ccsd.cnrs.fr/dumas-01302011

Influence of pharmacogenetics on indinavir disposition and short-term response in HIV patients initiating HAART

Autor: Julie, Bertrand, Jean-Marc, Treluyer, Xavière, Panhard, Agnes, Tran, Solange, Auleley, Elisabeth, Rey, Dominique, Salmon-Céron, Xavier, Duval, France, Mentré, X, Panhard

Publikováno v: European Journal of Clinical Pharmacology
European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (7), pp.667-678. ⟨10.1007/s00228-009-0660-5⟩
European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (7), pp.667-678. 〈10.1007/s00228-009-0660-5〉
European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (7), pp.667-78. ⟨10.1007/s00228-009-0660-5⟩
European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (7), pp.667-78. 〈10.1007/s00228-009-0660-5〉

International audience; AIMS: To assess the relationship between genetic polymorphisms and indinavir pharmacokinetic variability and to study the link between concentrations and short-term response or metabolic safety. METHODS: Forty protease inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f823f741fa0ce8ce72e9aee66009971a
https://hal.archives-ouvertes.fr/hal-00534961/document