Nanoscale co-organization and coactivation of AMPAR, NMDAR, and mGluR at excitatory synapses

Autor: Ana Paula Menegolla, Terrence J. Sejnowski, Tomas M. Bartol, Julia Goncalves, Come Camus, Michel Vivaudou, Florian Levet, Daniel Choquet, Eric Hosy, Jean-Baptiste Sibarita

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (25), pp.14503-14511. ⟨10.1073/pnas.1922563117⟩
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (25), pp.14503-14511. ⟨10.1073/pnas.1922563117⟩
Proc Natl Acad Sci U S A

International audience; The nanoscale co-organization of neurotransmitter receptors facing presynaptic release sites is a fundamental determinant of their coactivation and of synaptic physiology. At excitatory synapses, how endogenous AMPARs, NMDARs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a0ed12b242bbe4541a5c358a3e38bb

Toxoplasma Parasite Twisting Motion Mechanically Induces Host Cell Membrane Fission to Complete Invasion within a Protective Vacuole

Autor: Martial Balland, Bastien Touquet, Mateusz Biesaga, Georgios Pavlou, Isabelle Tardieux, Vanessa Lagal, Alexandre Dufour, Mohamed-Ali Hakimi

Publikováno v: Cell Host and Microbe
Cell Host and Microbe, 2018, 24 (1), pp.81-96.e5. ⟨10.1016/j.chom.2018.06.003⟩
Cell Host and Microbe, Elsevier, 2018, 24 (1), pp.81-96.e5. ⟨10.1016/j.chom.2018.06.003⟩

International audience; To invade cells, the parasite Toxoplasma gondii injects a multi-unit nanodevice into the target cell plasma membrane (PM). The core nanodevice, which is composed of the RhOptry Neck (RON) protein complex, connects Toxoplasma a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9a7422ea16110b1f986c6077d4407b
https://www.hal.inserm.fr/inserm-02440390

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential

Autor: Delphine Rigault, Francine Acher, Nadia Oueslati, Hervé Daniel, Marianne Amalric, Isabelle Brabet, Jean-Philippe Pin, Heather McLean, Hugues-Olivier Bertrand, Tiphanie Courtiol, Bruno Vilar, Thomas Bessiron, Cyril Goudet, Thierry Deltheil

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2012, 26 (4), pp.1682-93. ⟨10.1096/fj.11-195941⟩
FASEB Journal, 2012, 26 (4), pp.1682-93. ⟨10.1096/fj.11-195941⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2012, 26 (4), pp.1682-93. 〈10.1096/fj.11-195941〉

International audience; Metabotropic glutamate (mGlu) receptors are promising targets to treat numerous brain disorders. So far, allosteric modulators are the only subtype selective ligands, but pure agonists still have strong therapeutic potential.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8983843f27bc58d9bb94a0657cb437b2
https://ora.ox.ac.uk/objects/uuid:ef698f81-75c9-4a7c-865a-379868656d73

Identification of Cinnamic Acid Derivatives As Novel Antagonists of the Prokaryotic Proton-Gated Ion Channel GLIC

Autor: Pierre-Jean Corringer, Arnaud Blondel, Claire Colas, Sandrine Delarue-Cochin, Justine Marteaux, Catherine Van Renterghem, Delphine Joseph, Thérèse E. Malliavin, Marie S. Prevost

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2013, 56 (11), pp.4619-4630. ⟨10.1021/jm400374q⟩
Journal of Medicinal Chemistry, 2013, 56 (11), pp.4619-4630. ⟨10.1021/jm400374q⟩

International audience; Pentameric ligand gated ion channels (pLGICs) mediate signal transduction. The binding of an extracellular ligand is coupled to the transmembrane channel opening. So far, all known agonists bind at the interface between subuni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19385cb2b771a3793e47954364083df
https://doi.org/10.1021/jm400374q

Heterogeneous firing rate responses of mouse pyramidal cells

Autor: Zerlaut, Y., Teleńczuk, B., Deleuze, C., Bal, T., Ouanounou, G., Destexhe, A.

Publikováno v: The Journal of Physiology
The Journal of Physiology, Wiley, 2016, 594 (13), pp.3791-3808. ⟨10.1113/JP272317⟩

We recreated in vitro the fluctuation-driven regime observed at the soma during asynchronous network activity in vivo and we studied the firing rate response as a function of the properties of the membrane potential fluctuations. We provide a simple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::49ccc1a4a3d1eb9cd7aaa05638fd5982