Výsledky vyhledávání - "MESH : Oncogene Proteins"

TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases

Autor: Rachel Deplus, Martine Duterque-Coquillaud, Anne Flourens, Edith Bonnelye, Nathalie Vanpouille, Tian V. Tian, Philippe Clézardin, Anais Fradet, Carine Delliaux, Xavier Leroy, Yvan de Launoit, Mathilde Bouchet, Arnauld Villers

Publikováno v: Cancer Letters
Cancer Letters, Elsevier, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩
Cancer Letters, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩

International audience; Abstract : Prostate cancers have a strong propensity to metastasize to bone and promote osteoblastic lesions. TMPRSS2:ERG is the most frequent gene rearrangement identified in prostate cancer, but whether it is involved in pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2efdc0696479c6db9b921256206c223
https://doi.org/10.1016/j.canlet.2018.08.027

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TMPRSS2-ERG fusion promotes prostate cancer metastases in bone

Autor: Anne Flourens, Carine Delliaux, Yvan de Launoit, Xavier Leroy, Rachel Deplus, Martine Duterque-Coquillaud, Nathalie Marchand, Nathalie Vanpouille

Publikováno v: Oncotarget
Oncotarget, Impact journals, 2017, 8 (7), pp.11827-11840. ⟨10.18632/oncotarget.14399⟩
Oncotarget, 2017, 8 (7), pp.11827-11840. ⟨10.18632/oncotarget.14399⟩
Oncotarget, 8 (7

Bone metastasis is the major deleterious event in prostate cancer (PCa). TMPRSS2-ERG fusion is one of the most common chromosomic rearrangements in PCa. However, its implication in bone metastasis development is still unclear. Since bone metastasis s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6842a4a21bd05145fce04e57a3617d
https://hal.archives-ouvertes.fr/hal-02391621/file/TMPRSS2-ERG_fusion_promotes_prostate.pdf

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A non-conserved amino acid variant regulates differential signalling between human and mouse CD28

Autor: Marta Mastrogiovanni, Paola Grazioli, Antonio Francesco Campese, Loretta Tuosto, Balbino Alarcón, Silvana Caristi, Cédric Favre, Nicla Porciello, Francesca Spadaro, Jacques A. Nunès, Isabella Screpanti, Martina Kunkl, Michela Muscolini, Aldo Borroto

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1080. ⟨10.1038/s41467-018-03385-8⟩
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, 2018, 9 (1), pp.1080. ⟨10.1038/s41467-018-03385-8⟩
Digital.CSIC. Repositorio Institucional del CSIC
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CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29edf0332e8787c555c9b6ff4b29196e
https://hal.archives-ouvertes.fr/hal-01772994

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Identification of novel recurrent ETV6-IgH fusions in primary central nervous system lymphoma

Publikováno v: Neuro-Oncology
Neuro-Oncology, 2018, 20 (8), pp.1092-1100. ⟨10.1093/neuonc/noy019⟩
Neuro-Oncology, Oxford University Press (OUP), 2018, 20 (8), pp.1092-1100. ⟨10.1093/neuonc/noy019⟩

International audience; Background: Primary central nervous system lymphoma (PCNSL) represents a particular entity within non-Hodgkin lymphomas and is associated with poor outcome. The present study addresses the potential clinical relevance of chime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cc9f95aaa08e9662341fc6bbe9c176
https://hal-pasteur.archives-ouvertes.fr/pasteur-02862388

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Oncogenic Alterations in Papillary Thyroid Cancers of Young Patients

Autor: G. Sassolas, Z. Hafdi Nejjari, A. Ferraro, M. S. Gandhi, C. Kwon Jung, E. Borbone, M. Decaussin Petrucci, B. Rousset, F. Borson Chazot, N. Berger, FUSCO, ALFREDO

Publikováno v: Thyroid
Thyroid, Mary Ann Liebert, 2012, 22 (1), pp.17-26. ⟨10.1089/thy.2011.0215⟩
Thyroid, Mary Ann Liebert, 2012, 22 (1), pp.17-26. 〈10.1089/thy.2011.0215〉

International audience; BACKGROUND: Papillary thyroid carcinoma (PTC) in young people usually has an aggressive initial presentation, though a good general prognosis despite recurrences in 10%-20% of patients. A number of genetic alterations that act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab5df055f8b0ab0aa992889ca8dc30d
https://doi.org/10.1089/thy.2011.0215

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EWS-FLI1 inhibits TNFα-induced NFκB-dependent transcription in Ewing sarcoma cells

Autor: Christian Auclair, Franck Tirode, Olivier Delattre, Alain Lilienbaum, Julie Lagirand-Cantaloube, Marie-Hélène Kryszke, Karine Laud

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2010, 399 (4), pp.705-10. ⟨10.1016/j.bbrc.2010.08.004⟩
Biochemical and Biophysical Research Communications, Elsevier, 2010, 399 (4), pp.705-10. 〈10.1016/j.bbrc.2010.08.004〉

International audience; Ewing sarcoma is primarily caused by a t(11;22) chromosomal translocation encoding the EWS-FLI1 fusion protein. To exert its oncogenic function, EWS-FLI1 acts as an aberrant transcription factor, broadly altering the gene expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941e3a632b3037b2f736a357273979c4
https://doi.org/10.1016/j.bbrc.2010.08.004

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Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination

Autor: Lenden Hasse, Hélène, Lescale, Chloé, Bianchi, Joy, Yu, Wei, Bedora-Faure, Marie, Deriano, Ludovic

Publikováno v: Journal of Immunological Methods
Journal of Immunological Methods, Elsevier, 2017, 451, pp.71-77. ⟨10.1016/j.jim.2017.08.007⟩
Journal of Immunological Methods, 2017, 451, pp.71-77. ⟨10.1016/j.jim.2017.08.007⟩

International audience; Antigen receptor gene assembly is accomplished in developing lymphocytes by the V(D)J recombination reaction, which can be separated into two steps: DNA cleavage by the recombination-activating gene (RAG) nuclease and joining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e4dd926b4108c0406ce78aed8afe218f
https://hal-pasteur.archives-ouvertes.fr/pasteur-03271165/file/1-s2.0-S0022175917303447-main.pdf

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Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia

Autor: Bernard Mari, Elodie Portales-Casamar, Bruno Cassinat, Evelyne Friederich, Christine Chomienne, Khalil Arar, Pascal Barbry, Thomas Maurin, Anne Saumet, Manuella Bouttier, Laurent Vallar, Guillaume Vetter, Charles-Henri Lecellier, Wyeth W. Wasserman

Publikováno v: Blood
Blood, American Society of Hematology, 2009, 113 (2), pp.412-21. ⟨10.1182/blood-2008-05-158139⟩
Blood, American Society of Hematology, 2009, 113 (2), pp.412-21. 〈10.1182/blood-2008-05-158139〉

Micro(mi)RNAs are small noncoding RNAs that orchestrate many key aspects of cell physiology and their deregulation is often linked to distinct diseases including cancer. Here, we studied the contribution of miRNAs in a well-characterized human myeloi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e10ca83a269cddf272d030a7c52e468
https://doi.org/10.1182/blood-2008-05-158139

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HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial‐mesenchymal transition

Autor: Danilo Ranieri, Alessandra Magenta, Maria Rosaria Torrisi, Francesca Belleudi

Publikováno v: International Journal of Cancer
International Journal of Cancer, Wiley, 2015, 137 (1), pp.61-72. ⟨10.1002/ijc.29373⟩

International audience; The E5 oncoprotein of the human papillomavirus type 16 (HPV16 E5) deregulates epithelial homeostasis through the modulation of receptor tyrosine kinases and their signaling. Accordingly, the fibroblast growth factor receptor 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68418a30e3b14d59d0b0776b4b2f7f3
https://doi.org/10.1002/ijc.29373

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The human papillomavirus type 18 E6 oncoprotein induces Vascular Endothelial Growth Factor 121 (VEGF121) transcription from the promoter through a p53-independent mechanism

Autor: Marie-Laure Plissonnier, Nicolas Clere, Maëlle Saunier, Laurent Bermont, Isabelle Lascombe, Sylvie Fauconnet, Lucie Vettoretti, Christiane Mougin

Publikováno v: Experimental Cell Research
Experimental Cell Research, Elsevier, 2007, 313 (15), pp.3239-50. 〈10.1016/j.yexcr.2007.06.029〉
Experimental Cell Research, Elsevier, 2007, 313 (15), pp.3239-50. ⟨10.1016/j.yexcr.2007.06.029⟩

International audience; Altered angiogenic response is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular Endothelial Growth Factor (VEGF) is one of the most potent inducers of angiogenesis and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0f38cd76c8f69bbfa93497f4aea0ff
https://doi.org/10.1016/j.yexcr.2007.06.029

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