Contribution of IL-17-producing {gamma}{delta} T cells to the efficacy of anticancer chemotherapy

Autor: Laurent Boucontet, Laetitia Aymeric, Noelia Casares, Yuting Ma, Guido Kroemer, Nathalie Chaput, Nicolas Ibrahim, Laurence Zitvogel, Clara Locher, Goro Matsuzaki, Bernard Ryffel, Lionel Apetoh, Juan José Lasarte, François Ghiringhelli, Kamel Benlagha, Antoine Tesniere, Julie Déchanet-Merville, Stephen R. Mattarollo, Mark J. Smyth, Pablo Pereira, Nicolas F. Delahaye, Koichi Ikuta

Publikováno v: The Journal of Experimental Medecine
The Journal of Experimental Medecine, The Rockefeller University Press, 2011, 208 (3), pp.491-503. 〈10.1084/jem.20100269〉
The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, 2011, 208 (3), pp.491-503. ⟨10.1084/jem.20100269⟩
Journal of Experimental Medicine, Rockefeller University Press, 2011, 208 (3), pp.491-503. ⟨10.1084/jem.20100269⟩

IL-17 production by γδ T cells is required for tumor cell infiltration by IFN-γ–producing CD8+ T cells and inhibition of tumor growth in response to anthracyclines.
By triggering immunogenic cell death, some anticancer compounds, including

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https://hal-pasteur.archives-ouvertes.fr/pasteur-00576679/file/491.full.pdf