Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure

Autor: Aurelien Thureau, M. Longo, Anne Martel, Alessandro Paciaroni, Caterina Petrillo, Valeria Libera, Giorgio Schirò, Lucia Comez, Elena A. Andreeva

Publikováno v: Journal of Physical Chemistry Letters
Journal of Physical Chemistry Letters, American Chemical Society, 2021, 12 (33), pp.8096-8102. ⟨10.1021/acs.jpclett.1c01840⟩
Journal of Physical Chemistry Letters, 2021, 12 (33), pp.8096-8102. ⟨10.1021/acs.jpclett.1c01840⟩
Libera, V, Andreeva, E A, Martel, A, Thureau, A, Longo, M, Petrillo, C, Paciaroni, A, Schiro, G & Comez, L 2021, ' Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure ', Journal of Physical Chemistry Letters, vol. 12, no. 33, pp. 8096-8102 . https://doi.org/10.1021/acs.jpclett.1c01840

International audience; Nucleic acid sequences rich in guanines can organize into noncanonical DNA G-quadruplexes (G4s) of variable size. The design of small molecules stabilizing the structure of G4s is a rapidly growing area for the development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5db6f017436dba3641ee7e616c14d4e
https://hal.univ-grenoble-alpes.fr/hal-03385962

Stealth fluorescence labeling for live microscopy imaging of mRNA delivery

Autor: Elin K. Esbjörner, Jesper R. Nilsson, Audrey Gallud, Marcel Hollenstein, Cécile Gasse, Emanuele Celauro, Anders Dahlén, Fabienne Levi-Acobas, Tom Baladi, Ivo Sarac, L. Marcus Wilhelmsson

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 2021, 143 (14), pp.5413-5424. ⟨10.1021/jacs.1c00014⟩
Journal of the American Chemical Society, American Chemical Society, 2021, 143 (14), pp.5413-5424. ⟨10.1021/jacs.1c00014⟩

International audience; Methods for tracking RNA molecules inside living cells without perturbing their natural interactions and functions are critical within biology and, in particular, to facilitate studies of therapeutic RNA delivery. We present a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7d2187355619e1957adc2defc6f7db
https://doi.org/10.1101/2020.07.01.172767

Molecular Networking Reveals Serpentinine-Related Bisindole Alkaloids from Picralima nitida , a Previously Well-Investigated Species

Autor: Karine Leblanc, Elisabeth Mouray, Mehdi A. Beniddir, Charlotte Fox Alcover, Jean-François Gallard, Alexander E. Fox Ramos, Philippe Grellier, Faustin Aka Kabran, Guillaume Bernadat, Erwan Poupon, Pierre Le Pogam

Publikováno v: Journal of Natural Products
Journal of Natural Products, American Chemical Society, 2020, 83 (4), pp.1207-1216. ⟨10.1021/acs.jnatprod.9b01247⟩
Journal of Natural Products, 2020, 83 (4), pp.1207-1216. ⟨10.1021/acs.jnatprod.9b01247⟩

International audience; Five new monoterpene indole alkaloids (1-5), including four serpentinine-related bisindoles and one alstonine derivative monomer, have been isolated from the aerial parts of Picralima nitida. Their structures were elucidated b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b21e74903831a58ddba6e3ed154348
https://hal-mnhn.archives-ouvertes.fr/mnhn-02867383

Eumitrins C-E: Structurally diverse xanthone dimers from the vietnamese lichen Usnea baileyi

Autor: Pierre Le Pogam, Grégory Genta-Jouve, Solenn Ferron, Joël Boustie, Mehdi A. Beniddir, Van-Kieu Nguyen, Philippe Grellier, Warinthorn Chavasiri, Jean-François Gallard, Elisabeth Mouray, Thuc-Huy Duong

Publikováno v: Fitoterapia
Fitoterapia, 2020, 141, pp.104449. ⟨10.1016/j.fitote.2019.104449⟩
Fitoterapia, Elsevier, 2020, 141, pp.104449. ⟨10.1016/j.fitote.2019.104449⟩

International audience; Three new xanthone dimers, eumitrins C - E (1-3), along with a new depsidone, 3'-O-demethylcryptostictinolide (4) were isolated from the acetone extract of the whole thallus of the lichen Usnea baileyi collected in Vietnam. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fe31d00cb06f0b2b0e9432fa219c50
https://cnrs.hal.science/hal-04082752

Note of Caution for the Aqueous Behaviour of Metal‐Based Drug Candidates

Autor: Anna Notaro, Annie Castonguay, Gilles Gasser

Publikováno v: ChemMedChem
ChemMedChem, 2020, 15 (4), pp.345-348. ⟨10.1002/cmdc.201900677⟩

International audience; Poor aqueous solubility is one of the recurrent drawbacks of many compounds in medicinal chemistry. To overcome this limitation, the dilution of drug candidates from stock solutions of an organic solvent is common practice. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9626cf96089865457422d5bebb559ad2
https://hal.science/hal-03590601