Selective Targeting of Human and Animal Pathogens of the Helicobacter Genus by Flavodoxin Inhibitors: Efficacy, Synergy, Resistance and Mechanistic Studies

Autor: Ritwik Maity, Uwe Mamat, Ernesto Anoz-Carbonell, Javier Sancho, Eliette Touati, Sandra Salillas, María Conde-Giménez, Alejandro Mahía, María D. Díaz-de-Villegas, José A. Gálvez, José A. Aínsa, Ulrich E. Schaible, Adrián Velázquez-Campoy, Freddy Haesebrouck, Juan J. Galano-Frutos, Helena Berlamont

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10137, p 10137 (2021)
International Journal of Molecular Sciences
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences, 2021, 22 (18), pp.10137. ⟨10.3390/ijms221810137⟩
Volume 22
Issue 18

This article belongs to the Special Issue Antimicrobial Resistance, Molecular Mechanisms and Fight Strategies.
Antimicrobial resistant (AMR) bacteria constitute a global health concern. Helicobacter pylori is a Gram-negative bacterium that infec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126b38fef160907c5dd18da38f0bcb89
https://www.mdpi.com/1422-0067/22/18/10137

Purification and Characterization of Bot33: A Non-Toxic Peptide from the Venom of Buthus occitanus tunetanus Scorpion

Autor: Rym ElFessi, Oussema Khamessi, Najet Srairi-Abid, Jean-Marc Sabatier, Jan Tytgat, Steve Peigneur, Riadh Kharrat

Publikováno v: Molecules
Molecules, 2022, 27 (21), pp.7278. ⟨10.3390/molecules27217278⟩
Molecules; Volume 27; Issue 21; Pages: 7278

Scorpion venom is a rich source of promising therapeutic compounds, such as highly selective ion channel ligands with potent pharmacological effects. Bot33 is a new short polypeptide of 38 amino acid residues with six cysteines purified from the veno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a221efa035231934bfe4374af5d285
https://doi.org/10.3390/molecules27217278

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

Autor: Tyler N. Starr, Sarah K Hilton, Mary Jane Navarro, John E. Bowen, Jesse D. Bloom, M. Alejandra Tortorici, Neil P. King, David Veesler, Daniel Ellis, Alexandra C. Walls, Allison J. Greaney, Katharine H.D. Crawford, Adam S. Dingens

Publikováno v: Cell
Cell, Elsevier, 2020, 182 (5), pp.1295-1310.e20. ⟨10.1016/j.cell.2020.08.012⟩

International audience; The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor and is a major determinant of host range and a dominant target of neutralizing antibodies. Here, we experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c27c7d9c29520227bf651f416e7a83
https://hal-pasteur.archives-ouvertes.fr/pasteur-02984797

The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase

Autor: Andrew G. Watts, A. Carlos Frasch, Ricardo Resende, Jean M. H. van den Elsen, Susan J. Crennell, Patricia Marcé, Pedro M. Alzari, Zexin Chen

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 158, pp.25-33. ⟨10.1016/j.ejmech.2018.08.089⟩
Chen, Z, Marce Villa, P, Resende, R, Alzari, P M, Frasch, A C, Van Den Elsen, J, Crennell, S & Watts, A 2018, ' The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase ', European Journal of Medicinal Chemistry, vol. 158, pp. 25-33 . https://doi.org/10.1016/j.ejmech.2018.08.089
European Journal of Medicinal Chemistry, 2018, 158, pp.25-33. ⟨10.1016/j.ejmech.2018.08.089⟩

The trans-sialidase protein expressed by Trypanosoma cruzi is an important enzyme in the life cycle of this human pathogenic parasite and is considered a promising target for the development of new drug treatments against Chagas' disease. Here we des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ddfe1a4a8535e8f8ad3c5e44d9ceac
https://doi.org/10.1016/j.ejmech.2018.08.089

Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1

Autor: Manfred Jung, Karin Schmidtkunz, Elizabeth R Morales, Stefan Günther, Wolfgang Sippl, Martin Hügle, Frank Erdmann, Patrik Zeyen, Ehab Ghazy, Dina Robaa, Christophe Romier, Matthias Schmidt, Daniel Herp

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2020, 200, pp.112338. ⟨10.1016/j.ejmech.2020.112338⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 200, pp.112338. ⟨10.1016/j.ejmech.2020.112338⟩

International audience; Histone modifying proteins, specifically histone deacetylases (HDACs) and bromodomains, have emerged as novel promising targets for anticancer therapy. In the current work, based on available crystal structures and docking stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738621ff6d5b1624d9660f91e10c4ab7
https://hal.science/hal-02999300/document