Výsledky vyhledávání - "MESH : MicroRNAs"

Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response

Autor: Tobias Sahr, Pedro Escoll, Christophe Rusniok, Sheryl Bui, Gérard Pehau-Arnaudet, Gregory Lavieu, Carmen Buchrieser

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Nature Communications
Nature Communications, 2022, 13 (1), pp.762. ⟨10.1038/s41467-022-28454-x⟩

Legionella pneumophila is an intracellular bacterial pathogen that can cause a severe form of pneumonia in humans, a phenotype evolved through interactions with aquatic protozoa in the environment. Here, we show that L. pneumophila uses extracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49f43e4ba39cbe29ea18dd8e092f768
https://doi.org/10.1038/s41467-022-28454-x

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Lung Fibrosis Is Improved by Extracellular Vesicles from IFNγ-Primed Mesenchymal Stromal Cells in Murine Systemic Sclerosis

Autor: Rozier, Pauline, Maumus, Marie, Maria, Alexandre Thibault Jacques, Toupet, Karine, Jorgensen, Christian, Guilpain, Philippe, Noël, Danièle

Publikováno v: Cells
Volume 10
Issue 10
Cells, Vol 10, Iss 2727, p 2727 (2021)
Cells, MDPI, 2021, 10 (10), pp.2727. ⟨10.3390/cells10102727⟩

International audience; Background: Systemic sclerosis (SSc) is a severe autoimmune disease for which mesenchymal stromal cells (MSCs)-based therapy was reported to reduce SSc-related symptoms in pre-clinical studies. Recently, extracellular vesicles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2622f72de58c8909faf720e3f84a9f69

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Deregulation of microRNA expression in monocytes and CD4+ T lymphocytes from patients with axial spondyloarthritis

Autor: Fogel, Olivier, Bugge Tinggaard, Andreas, Fagny, Maud, Sigrist, Nelly, Roche, Elodie, Leclere, Laurence, Deleuze, Jean-François, Batteux, Frederic, Dougados, Maxime, Miceli-Richard, Corinne, Tost, Jörg

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-14 (2019)
Fogel, O, Bugge Tinggaard, A, Fagny, M, Sigrist, N, Roche, E, Leclere, L, Deleuze, J F, Batteux, F, Dougados, M, Miceli-Richard, C & Tost, J 2019, ' Deregulation of microRNA expression in monocytes and CD4 + T lymphocytes from patients with axial spondyloarthritis ', Arthritis Research and Therapy, vol. 21, no. 1, 51 . https://doi.org/10.1186/s13075-019-1829-7
Arthritis Research & Therapy
Arthritis Research & Therapy, 2019, 21 (1), pp.1-14. ⟨10.1186/s13075-019-1829-7⟩

BACKGROUND: MicroRNAs (MiRs) play an important role in the pathogenesis of chronic inflammatory diseases. This study is the first to investigate miR expression profiles in purified CD4+ T lymphocytes and CD14+ monocytes from patients with axial spond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::01ef52145922e8a7a7ed78dcfaf772cc
http://link.springer.com/article/10.1186/s13075-019-1829-7

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MicroRNAs Associated With a Good Prognosis of Acute Myeloid Leukemia and Their Effect on Macrophage Polarization

Autor: Alexandra Neaga, Cristina Bagacean, Adrian Tempescul, Laura Jimbu, Oana Mesaros, Cristina Blag, Ciprian Tomuleasa, Corina Bocsan, Mihaela Gaman, Mihnea Zdrenghea

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2021, 11, pp.582915. ⟨10.3389/fimmu.2020.582915⟩
Frontiers in Immunology, Vol 11 (2021)

International audience; Acute myeloid leukemia (AML) is an aggressive myeloid malignancy with poor outcomes despite very intensive therapeutic approaches. For the majority of patients which are unfit and treated less intensively, the prognosis is eve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05d116c053505ae2ddbef303a40fb51
https://doi.org/10.3389/fimmu.2020.582915

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Use of microRNA‐encoded peptides to improve agronomic traits

Autor: Ormancey, Mélanie, Guillotin, Bruno, San Clemente, Hélène, Thuleau, Patrice, Plaza, Serge, Combier, Jean‐Philippe

Publikováno v: Plant Biotechnology Journal
Plant Biotechnology Journal, Wiley, 2021, 19 (9), pp.1687-1689. ⟨10.1111/pbi.13654⟩

International audience; MicroRNAs (miRNAs) are small regulatory RNA molecules (21–24 nt) regulating the expression of target genes at the post-transcriptional level, by cleaving their mRNA. Because these target genes are mainly regulatory genes, mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8b637ae003ffbc873246d5961adea417
https://hal.archives-ouvertes.fr/hal-03360224

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Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (49), pp.31278-31289. ⟨10.1073/pnas.2010782117⟩
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (49), pp.31278-31289. ⟨10.1073/pnas.2010782117⟩
Proc Natl Acad Sci U S A

International audience; Presbycusis, or age-related hearing loss (ARHL), is a major public health issue. About half the phenotypic variance has been attributed to genetic factors. Here, we assessed the contribution to presbycusis of ultrarare pathoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bb30ca4931ea88956d1a4bd7843bdb
https://hal-pasteur.archives-ouvertes.fr/pasteur-03215054

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Autophagy inhibition blunts PDGFRA adipose progenitors' cell-autonomous fibrogenic response to high-fat diet

Autor: Nadine Suffee, Geneviève Marcelin, Emmanuel L. Gautier, Amélie Lacombe, Carla Da Cunha, Isabelle Dugail, Christine Rouault, Nataliya Sokolovska, Karine Clément, Arnaud Leclerc, Camille Gamblin

Publikováno v: Autophagy
Autophagy, 2020, 16 (12), pp.2156-2166. ⟨10.1080/15548627.2020.1717129⟩
Autophagy, 2020, 16 (12), Epub ahead of print. ⟨10.1080/15548627.2020.1717129⟩
Autophagy, Taylor & Francis, 2020, Epub ahead of print. ⟨10.1080/15548627.2020.1717129⟩

International audience; Adipose tissue (AT) fibrosis in obesity compromises adipocyte functions and responses to intervention-induced weight loss. It is driven by AT progenitors with dual fibro/adipogenic potential, but pro-fibrogenic pathways activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12def550e67c96ae654a1b812d9d43f
https://pubmed.ncbi.nlm.nih.gov/31992125

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Identification of a functional FADS1 3′UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels

Autor: Xavier Hermant, Amandine Flaig, Dominique Cottel, Gilbert Briand, Brigitte Laillet, Chantal Simon, Aline Meirhaeghe, Marie-Adélaïde Bout, Julie Dumont, Dominique Arveiler, Aline Wagner, Jean Dallongeville, Charlotte Delay, Jean-Bernard Ruidavets, Jimena Luque-Bedregal, Jean Ferrières, Philippe Amouyel

Publikováno v: Journal of clinical lipidology
Journal of clinical lipidology, Elsevier, 2018, 12 (5), pp.1280--1289. ⟨10.1016/j.jacl.2018.07.012⟩
Journal of clinical lipidology, 2018, 12 (5), pp.1280--1289. ⟨10.1016/j.jacl.2018.07.012⟩

International audience; BACKGROUND: Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Delta 5- and Delta 6-desaturases (encoded by the FADS] and FADS2 genes, respectively). Genome-wide association s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776b9882168384015577c4c64face99e
https://doi.org/10.1016/j.jacl.2018.07.012

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The multiple therapeutic applications of miRNAs for bone regenerative medicine

Autor: Elise Verron, Jean-Claude Scimeca

Publikováno v: Drug Discovery Today Biosilico
Drug Discovery Today Biosilico, Elsevier, 2017, 22 (7), pp.1084-1091. ⟨10.1016/j.drudis.2017.04.007⟩

International audience; With the aging of the general population, there is an increasing need for bone defect repair, prompting the development of reliable alternatives to autologous bone grafting, without the usually associated major drawbacks (i.e.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0f7defbc40b9699d4d78686499cf15
https://doi.org/10.1016/j.drudis.2017.04.007

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Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma

Autor: Chantal Etievant, Audrey Delmas, Paola B. Arimondo, Arnaud Pillon, Gilles Favre, Joëlle Riond, Jörg Tost, Arnaud Carrier, Florence Busato, Cécile Desjobert, Antoine Daunay, Diego M. Marzese

Publikováno v: Clinical Epigenetics
Clinical Epigenetics, BioMed Central, 2019, 11 (1), pp.9. ⟨10.1186/s13148-018-0600-2⟩
Clinical Epigenetics, 2019, 11 (1), pp.9. ⟨10.1186/s13148-018-0600-2⟩
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-14 (2019)

Background Efficient treatments against metastatic melanoma dissemination are still lacking. Here, we report that low-cytotoxic concentrations of 5-aza-2′-deoxycytidine, a DNA demethylating agent, prevent in vitro 3D invasiveness of metastatic mela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2d0bd1fdcfffb79fe1386702dbb4b7
https://hal.archives-ouvertes.fr/hal-02332300

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