Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

Autor: Shahragim Tajbakhsh, Wolf Reik, Brendan Evano, Thomas M. Stubbs, Pierre-Henri Commere, Marc Jan Bonder, Stephen J. Clark, Simon Andrews, Irene Hernando-Herraez

Publikováno v: Nature Communications
Nature Communications, 2019, 10 (1), pp.4361. ⟨10.1038/s41467-019-12293-4⟩
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.4361. ⟨10.1038/s41467-019-12293-4⟩

Age-related tissue alterations have been associated with a decline in stem cell number and function. Although increased cell-to-cell variability in transcription or epigenetic marks has been proposed to be a major hallmark of ageing, little is known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8102a8ae6840250a67fc2cc2bb49001d
https://hal-pasteur.archives-ouvertes.fr/pasteur-03105560/document

Signalling pathways regulating muscle mass in ageing skeletal muscle

Autor: Luana Toniolo, L. Barberi, Astrid Y. Bijlsma, Antonio L. Serrano, Carel G. M. Meskers, Lars Larsson, Mario Pende, Rosario Rizzuto, Marco Sandri, Kenneth A. Dyar, Cristina Mammucari, Andrea B. Maier, Giorgia Pallafacchina, M. Roceri, Pura Muñoz-Cánoves, Stefano Schiaffino, Antonio Paoli, D. Pion, Giulia Milan, Bert Blaauw, Antonio Musarò, Carlo Reggiani, Vanina Romanello

Publikováno v: Biogerontology, 14(3), 303-23. Springer Netherlands
Biogerontology
Biogerontology, Springer Verlag, 2013, 14 (3), pp.303-23. ⟨10.1007/s10522-013-9432-9⟩
Biogerontology; Vol 14
Sandri, M, Barberi, L, Bijlsma, A Y, Blaauw, B, Dyar, K A, Milan, G, Mammucari, C, Meskers, C G M, Pallafacchina, G, Paoli, A, Pion, D, Roceri, M, Romanello, V, Serrano, A L, Toniolo, L, Larsson, L, Maier, A B, Munoz-Canoves, P, Musaro, A, Pende, M, Reggiani, C, Rizzuto, R & Schiaffino, S 2013, ' Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway ', Biogerontology, vol. 14, no. 3, pp. 303-323 . https://doi.org/10.1007/s10522-013-9432-9
Biogerontology, 2013, 14 (3), pp.303-23. ⟨10.1007/s10522-013-9432-9⟩
Biogerontology, 14(3), 303-323. Springer Netherlands
Biogerontology, 14(3), 303-323
Sandri, M, Barberi, L, Bijlsma, A Y, Blaauw, B, Dyar, K A, Milan, G, Mammucari, C, Meskers, C G M, Pallafacchina, G, Paoli, A, Pion, D, Roceri, M, Romanello, V, Serrano, A L, Toniolo, L, Larsson, L, Maier, A B, Muñoz-Cánoves, P, Musarò, A, Pende, M, Reggiani, C, Rizzuto, R & Schiaffino, S 2013, ' Signalling pathways regulating muscle mass in ageing skeletal muscle : the role of the IGF1-Akt-mTOR-FoxO pathway ', Biogerontology, vol. 14, no. 3, pp. 303-23 . https://doi.org/10.1007/s10522-013-9432-9

International audience; During ageing skeletal muscles undergo a process of structural and functional remodelling that leads to sarcopenia, a syndrome characterized by loss of muscle mass and force and a major cause of physical frailty. To determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f4a5d65f36ee74ba4de2ecd531c858
https://hdl.handle.net/1871.1/c3edf814-3c90-4667-8713-c3a120aff07a

Molecular Signature of Recent Thymic Selection Events on Effector and Regulatory CD4+ T Lymphocytes

Autor: Denis Hudrisier, Paola Romagnoli, Joost P. M. van Meerwijk

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2005, 175 (9), pp.5751-8
ResearcherID
Journal of Immunology, 2005, 175 (9), pp.5751-8

Natural CD4+CD25+ regulatory T lymphocytes (Treg) are key protagonists in the induction and maintenance of peripheral T cell tolerance. Their thymic origin and biased repertoire continue to raise important questions about the signals that mediate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48b8b80c05adebbb83b0e165f4e12c1
https://doi.org/10.4049/jimmunol.175.9.5751

Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor

Autor: Elisabeth Filipski, Rune Smaaland, Paolo Sassone-Corsi, Teresa G. Granda, Nicolas Cermakian, Francis Lévi, Xu-Hui Liu

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2005, 19 (2), pp.304-6. ⟨10.1096/fj.04-2665fje⟩

International audience; Proapoptotic drugs such as docetaxel displayed least toxicity and highest antitumor efficacy following dosing during the circadian rest phase in mice, suggesting that cell cycle and apoptotic processes could be regulated by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892344840cfce5a824d3daf62624b287
https://doi.org/10.1096/fj.04-2665fje

Insights into spatial configuration of a galactosylated epitope required to trigger arthritogenic T-cell receptors specific for the sugar moiety

Autor: Gilles Chiocchia, Jean-Paul Briand, Simon Glatigny, Marie-Agnès Blaton, Gilles Guichard, Sylvie Mistou, Catherine Fournier, Julien Marin

Publikováno v: Arthritis Research and Therapy
Arthritis Research and Therapy, BioMed Central, 2007, 9 (5), pp.R92. ⟨10.1186/ar2291⟩
Arthritis Research and Therapy, BioMed Central, 2007, 9 (5), pp.R92. 〈10.1186/ar2291〉
Arthritis Research & Therapy
Scopus-Elsevier

The immunodominant epitope of bovine type II collagen (CII256-270) in Aq mice carries a hydroxylysine-264 linked galactose (Gal-Hyl264), the recognition of which is central to the development of collagen-induced arthritis. This study explores the mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5507465081d454afbb1b4d279e78956
https://hal.archives-ouvertes.fr/hal-00281001