Dual-drug loaded nanomedicine hydrogel as a therapeutic platform to target both residual glioblastoma and glioma stem cells

Autor: Elia Bozzato, Nikolaos Tsakiris, Adrien Paquot, Giulio G. Muccioli, Chiara Bastiancich, Véronique Préat

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, 2022, 628, pp.122341. ⟨10.1016/j.ijpharm.2022.122341⟩

Glioblastoma (GBM) recurrences are inevitable, and mainly originate from residual tumor cells and the presence of glioma stem cells (GSC) around the resection cavity borders. We previously showed that the local treatment of GBM with nanomedicine-base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6455d6d0fe1252edd6fcd2ec01668a
https://hdl.handle.net/2318/1879766

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Autor: Sina A. Gharib, Kenneth Rice, Donna K. Arnett, Tõnu Esko, Annemarie I. Luik, Niki Dimou, Dabeeru C. Rao, Pamela J. Schreiner, Melissa A. Richard, Reedik Mägi, Nicholette D. Palmer, Stefan Weiss, Han Chen, Solomon K. Musani, W. James Gauderman, Christian Gieger, Kari E. North, Salman M. Tajuddin, Diana van Heemst, Rainer Rauramaa, Stephen B. Kritchevsky, Henry Völzke, Minjung Kho, Michele K. Evans, Ruth J. F. Loos, Correa Adolfo, Pedro Marques-Vidal, Diane M. Becker, Claude Bouchard, José Haba-Rubio, Georg Homuth, Kurt Lohman, Nora Franceschini, Caizheng Yu, Peter Vollenweider, Ervin F. Fox, Thomas Meitinger, Karen Schwander, Heming Wang, Morris A. Swertz, Aldi T. Kraja, José Eduardo Krieger, Xiuqing Guo, Tangchun Wu, Raymond Noordam, Yongmei Liu, Michael R. Brown, Patrick C.N. Rensen, Annette Peters, Jingmin Liu, Tuomo Rankinen, Robert B. Wallance, Timo A. Lakka, Stephen S. Rich, Yun Ju Sung, Meian He, Till Roenneberg, Wanqing Wen, Dennis O. Mook-Kanamori, M. A. Province, Evangelos Evangelou, L. Adrienne Cupples, Maxime M Bos, Paul S. de Vries, Hans J. Grabe, Lisa R. Yanek, Jiwon Lee, Mario Sims, Bruce M. Psaty, Treva Rice, Tanika N. Kelly, Brenda W.J.H. Penninx, Brigitte Kühnel, Maria E. Graff, Alexandre C. Pereira, Daniel J. Gottlieb, Charles N. Rotimi, Lynne E. Wagenknecht, Ashley van der Spek, Lisa W. Martin, Jeffrey R. O'Connell, Changwei Li, James E. Hixson, Chuan Gao, Alisa K. Manning, Sharon L.R. Kardia, Stella Aslibekyan, Andres Metspalu, Sami Heikkinen, Maris Alver, Xiao-Ou Shu, Amy R. Bentley, Susan Redline, Konstantin Strauch, Tamara B. Harris, Yuri Milaneschi, L.F. Bielak, Marjan Ilkov, Myriam Fornage, Ilja M. Nolte, André G. Uitterlinden, Dina Vojinovic, Hugues Aschard, Paul Elliott, Kent D. Taylor, Najaf Amin, James M. Shikany, Yong-Bing Xiang, Jerome I. Rotter, Vilmundur Gudnason, Cornelia M. van Duijn, Ko Willems van Dijk, Andrea R. V. R. Horimoto, Jonathan Marten, Olli T. Raitakari, Vincent Laville, Pirjo Komulainen, Zhe Wang, Traci M. Bartz, Mary F. Feitosa, Mike A. Nalls, Eric Boerwinkle, Alanna C. Morrison, Melanie Waldenberger, Alexander P. Reiner, Christie M. Ballantyne, Wei Zheng, Raphael Heinzer, M. Arfan Ikram, Colleen M. Sitlani, Lisa de las Fuentes, Patricia B. Munroe, Patricia A. Peyser, Brian E. Cade, Tamar Sofer, Xiaofeng Zhu, Nienke R. Biermasz, Harold Snieder, Elise Lim, Tuomas O. Kilpeläinen, Ching-Ti Liu, Terho Lehtimäki, Thomas W. Winkler, Leo-Pekka Lyytikäinen, Gudny Eiriksdottir, Stephen Sidney, Alan B. Zonderman, Charles Kooperberg

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications, 2019, 10 (1), pp.5121. ⟨10.1038/s41467-019-12958-0⟩
Nature Communications, 10. NATURE PUBLISHING GROUP
Nature Communications, 10:5121. Nature Publishing Group
Nature Communications, 10(1):5121. Nature Publishing Group
Nature Communications, 10(1):5121. Nature Publishing Group UK
Noordam, R, Bos, M M, Wang, H, Winkler, T W, Bentley, A R, Kilpeläinen, T O, de Vries, P S, Sung, Y J, Schwander, K, Cade, B E, Manning, A, Aschard, H, Brown, M R, Chen, H, Franceschini, N, Musani, S K, Richard, M, Vojinovic, D, Aslibekyan, S, Bartz, T M, de las Fuentes, L, Feitosa, M, Horimoto, A R, Ilkov, M, Kho, M, Kraja, A, Li, C, Lim, E, Liu, Y, Mook-Kanamori, D O, Rankinen, T, Tajuddin, S M, van der Spek, A, Wang, Z, Marten, J, Laville, V, Alver, M, Evangelou, E, Graff, M E, He, M, Kühnel, B, Lyytikäinen, L P, Marques-Vidal, P, Nolte, I M, Palmer, N D, Rauramaa, R, Shu, X O, Snieder, H, Weiss, S & Penninx, B W J H 2019, ' Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration ', Nature Communications, vol. 10, no. 1, 5121 . https://doi.org/10.1038/s41467-019-12958-0
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5121. ⟨10.1038/s41467-019-12958-0⟩
Noordam, R, Bos, M M, Wang, H, Winkler, T W, Bentley, A R, Kilpeläinen, T O, de Vries, P S, Sung, Y J, Schwander, K, Cade, B E, Manning, A, Aschard, H, Brown, M R, Chen, H, Franceschini, N, Musani, S K, Richard, M, Vojinovic, D, Aslibekyan, S, Bartz, T M, de Las Fuentes, L, Feitosa, M, Horimoto, A R, Ilkov, M, Kho, M, Kraja, A, Li, C, Lim, E, Liu, Y, Mook-Kanamori, D O, Rankinen, T, Tajuddin, S M, van der Spek, A, Wang, Z, Marten, J, Laville, V, Alver, M, Evangelou, E, Graff, M E, He, M, Kühnel, B, Lyytikäinen, L-P, Marques-Vidal, P, Nolte, I M, Palmer, N D, Rauramaa, R, Shu, X-O, Snieder, H, Weiss, S, Wen, W, Yanek, L R, Adolfo, C, Ballantyne, C, Bielak, L, Biermasz, N R, Boerwinkle, E, Dimou, N, Eiriksdottir, G, Gao, C, Gharib, S A, Gottlieb, D J, Haba-Rubio, J, Harris, T B, Heikkinen, S, Heinzer, R, Hixson, J E, Homuth, G, Ikram, M A, Komulainen, P, Krieger, J E, Lee, J, Liu, J, Lohman, K K, Luik, A I, Mägi, R, Martin, L W, Meitinger, T, Metspalu, A, Milaneschi, Y, Nalls, M A, O'Connell, J, Peters, A, Peyser, P, Raitakari, O T, Reiner, A P, Rensen, P C N, Rice, T K, Rich, S S, Roenneberg, T, Rotter, J I, Schreiner, P J, Shikany, J, Sidney, S S, Sims, M, Sitlani, C M, Sofer, T, Strauch, K, Swertz, M A, Taylor, K D, Uitterlinden, A G, van Duijn, C M, Völzke, H, Waldenberger, M, Wallance, R B, van Dijk, K W, Yu, C, Zonderman, A B, Becker, D M, Elliott, P, Esko, T, Gieger, C, Grabe, H J, Lakka, T A, Lehtimäki, T, North, K E, Penninx, B W J H, Vollenweider, P, Wagenknecht, L E, Wu, T, Xiang, Y-B, Zheng, W, Arnett, D K, Bouchard, C, Evans, M K, Gudnason, V, Kardia, S, Kelly, T N, Kritchevsky, S B, Loos, R J F, Pereira, A C, Province, M, Psaty, B M, Rotimi, C, Zhu, X, Amin, N, Cupples, L A, Fornage, M, Fox, E F, Guo, X, Gauderman, W J, Rice, K, Kooperberg, C, Munroe, P B, Liu, C-T, Morrison, A C, Rao, D C, van Heemst, D & Redline, S 2019, ' Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration ', Nature Communications, vol. 10, no. 1, 5121 . https://doi.org/10.1038/s41467-019-12958-0
Nature communications, vol. 10, no. 1, pp. 5121

Publisher's version (útgefin grein).
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b5fb699bc64fdb1c35600118d5f0de
https://doaj.org/article/7a287494756c4fbcb7eb0688fb50e01b

Lipid Biomarkers in Alzheimer's Disease

Autor: Gérard Lizard, Mohamed Hammami, Amira Zarrouk, Mohamed El Ayeb, Thibault Moreau, Mustapha Cherkaoui-Malki, Meryam Debbabi, El Mostafa Karym, Boubker Nasser, Asmaa Badreddine, Maryem Bezine, Olivier Rouaud

Publikováno v: Current Alzheimer Research
Current Alzheimer Research, Bentham Science Publishers, 2018, 15 (4), pp.303-312. ⟨10.2174/1567205014666170505101426⟩

Background: There are now significant evidences that lipid metabolism is affected in numerous neurodegenerative diseases including Alzheimer’s disease. These dysfunctions lead to abnormal levels of certain lipids in the brain, cerebrospinal fluid a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bf82a1ad571e36b041dd63256dd671
https://doi.org/10.2174/1567205014666170505101426

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Autor: Bentley, Amy R, Sung, Yun J, Brown, Michael R, Winkler, Thomas W, Kraja, Aldi T, Ntalla, Ioanna, Schwander, Karen, Chasman, Daniel I, Lim, Elise, Deng, Xuan, Guo, Xiuqing, Liu, Jingmin, Lu, Yingchang, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Huffman, Jennifer E, Musani, Solomon K, Li, Changwei, Feitosa, Mary F, Richard, Melissa A, Noordam, Raymond, Baker, Jenna, Chen, Guanjie, Aschard, Hugues, Bartz, Traci M, Ding, Jingzhong, Dorajoo, Rajkumar, Manning, Alisa K, Rankinen, Tuomo, Smith, Albert V, Tajuddin, Salman M, Zhao, Wei, Graff, Mariaelisa, Alver, Maris, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Goel, Anuj, Hagemeijer, Yanick, Harris, Sarah E, Hartwig, Fernando P, He, Meian, Horimoto, Andrea RVR, Hsu, Fang-Chi, Hung, Yi-Jen, Jackson, Anne U, Kasturiratne, Anuradhani, Komulainen, Pirjo, Kuehnel, Brigitte, Leander, Karin, Lin, Keng-Hung, Luan, Jian'an, Lyytikainen, Leo-Pekka, Matoba, Nana, Nolte, Ilja M, Pietzner, Maik, Prins, Bram, Riaz, Muhammad, Robino, Antonietta, Said, M Abdullah, Schupf, Nicole, Scott, Robert A, Sofer, Tamar, Stancakova, Alena, Takeuchi, Fumihiko, Tayo, Bamidele O, van der Most, Peter J, Varga, Tibor V, Wang, Tzung-Dau, Wang, Yajuan, Ware, Erin B, Wen, Wanqing, Xiang, Yong-Bing, Yanek, Lisa R, Zhang, Weihua, Zhao, Jing Hua, Adeyemo, Adebowale, Afaq, Saima, Amin, Najaf, Amini, Marzyeh, Arking, Dan E, Arzumanyan, Zorayr, Aung, Tin, Ballantyne, Christie, Barr, R Graham, Bielak, Lawrence F, Boerwinkle, Eric, Bottinger, Erwin P, Broeckel, Ulrich, Brown, Morris, Cade, Brian E, Campbell, Archie, Canouil, Mickael, Charumathi, Sabanayagam, Chen, Yii-Der Ida, Christensen, Kaare, Concas, Maria Pina, Connell, John M, de las Fuentes, Lisa, de Silva, H Janaka, de Vries, Paul S, Doumatey, Ayo, Duan, Qing, Eaton, Charles B, Eppinga, Ruben N, Faul, Jessica D, Floyd, James S, Forouhi, Nita G, Forrester, Terrence, Friedlander, Yechiel, Gandin, Ilaria, Gao, He, Ghanbari, Mohsen, Gharib, Sina A, Gigante, Bruna, Giulianini, Franco, Grabe, Hans J, Gu, C Charles, Harris, Tamara B, Heikkinen, Sami, Heng, Chew-Kiat, Hirata, Makoto, Hixson, James E, Ikram, M Arfan, Jia, Yucheng, Joehanes, Roby, Johnson, Craig, Jonas, Jost Bruno, Justice, Anne E, Katsuya, Tomohiro, Khor, Chiea Chuen, Kilpelainen, Tuomas O, Koh, Woon-Puay, Kolcic, Ivana, Kooperberg, Charles, Krieger, Jose E, Kritchevsky, Stephen B, Kubo, Michiaki, Kuusisto, Johanna, Lakka, Timo A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lehne, Benjamin, Lewis, Cora E, Li, Yize, Liang, Jingjing, Lin, Shiow, Liu, Ching-Ti, Liu, Jianjun, Liu, Kiang, Loh, Marie, Lohman, Kurt K, Louie, Tin, Luzzi, Anna, Magi, Reedik, Mahajan, Anubha, Manichaikul, Ani W, McKenzie, Colin A, Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Milani, Lili, Mohlke, Karen L, Momozawa, Yukihide, Morris, Andrew P, Murray, Alison D, Nalls, Mike A, Nauck, Matthias, Nelson, Christopher P, North, Kari E, O'Connell, Jeffrey R, Palmer, Nicholette D, Papanicolau, George J, Pedersen, Nancy L, Peters, Annette, Peyser, Patricia A, Polasek, Ozren, Poulter, Neil, Raitakari, Olli T, Reiner, Alex P, Renstrom, Frida, Rice, Treva K, Rich, Stephen S, Robinson, Jennifer G, Rose, Lynda M, Rosendaal, Frits R, Rudan, Igor, Schmidt, Carsten O, Schreiner, Pamela J, Scott, William R, Sever, Peter, Shi, Yuan, Sidney, Stephen, Sims, Mario, Smith, Jennifer A, Snieder, Harold, Starr, John M, Strauch, Konstantin, Stringham, Heather M, Tan, Nicholas YQ, Tang, Hua, Taylor, Kent D, Teo, Yik Ying, Tham, Yih Chung, Tiemeier, Henning, Turner, Stephen T, Uitterlinden, Andre G, van Heemst, Diana, Waldenberger, Melanie, Wang, Heming, Wang, Lan, Wang, Lihua, Wei, Wen Bin, Williams, Christine A, Sr, Wilson Gregory, Wojczynski, Mary K, Yao, Jie, Young, Kristin, Yu, Caizheng, Yuan, Jian-Min, Zhou, Jie, Zonderman, Alan B, Becker, Diane M, Boehnke, Michael, Bowden, Donald W, Chambers, John C, Cooper, Richard S, de Faire, Ulf, Deary, Ian J, Elliott, Paul, Esko, Tonu, Farrall, Martin, Franks, Paul W, Freedman, Barry I, Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Horta, Bernardo L, Juang, Jyh-Ming Jimmy, Kamatani, Yoichiro, Kammerer, Candace M, Kato, Norihiro, Kooner, Jaspal S, Laakso, Markku, Laurie, Cathy C, Lee, I-Te, Lehtimaki, Terho, Magnusson, Patrik KE, Oldehinkel, Albertine J, Penninx, Brenda WJH, Pereira, Alexandre C, Rauramaa, Rainer, Redline, Susan, Samani, Nilesh J, Scott, James, Shu, Xiao-Ou, van der Harst, Pim, Wagenknecht, Lynne E, Wang, Jun-Sing, Wang, Ya Xing, Wareham, Nicholas J, Watkins, Hugh, Weir, David R, Wickremasinghe, Ananda R, Wu, Tangchun, Zeggini, Eleftheria, Zheng, Wei, Bouchard, Claude, Evans, Michele K, Gudnason, Vilmundur, Kardia, Sharon LR, Liu, Yongmei, Psaty, Bruce M, Ridker, Paul M, van Dam, Rob M, Mook-Kanamori, Dennis O, Fornage, Myriam, Province, Michael A, Kelly, Tanika N, Fox, Ervin R, Hayward, Caroline, van Duijn, Cornelia M, Tai, E Shyong, Wong, Tien Yin, Loos, Ruth JF, Franceschini, Nora, Rotter, Jerome I, Zhu, Xiaofeng, Bierut, Laura J, Gauderman, W James, Rice, Kenneth, Munroe, Patricia B, Morrison, Alanna C, Rao, Dabeeru C, Rotimi, Charles N, Cupples, L Adrienne, Consortium, COGENT-Kidney, Consortium, EPIC-InterAct, Grp, Understanding Soc Sci, Cohort, Lifelines

Publikováno v: Nature Genetics
Nature Genetics, Nature Publishing Group, 2019, 51 (4), pp.636-648. ⟨10.1038/s41588-019-0378-y⟩
NATURE GENETICS
Nature Genetics, 51(4), 636
Bentley, A R, Sung, Y J, Brown, M R, Winkler, T W, Kraja, A T, Ntalla, I, Schwander, K, Chasman, D I, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, C-Y, Sim, X, Vojinovic, D, Huffman, J E, Musani, S K, Li, C, Feitosa, M F, Richard, M A, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, T M, Ding, J, Dorajoo, R, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, Hartwig, F P, He, M, Horimoto, A R V R, Milaneschi, Y, Yuan, J-M, Penninx, B W J H, COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Society Scientific group, Lifelines Cohort, Pereira, C, Rauramaa, R, Redline, S, Samani, N J, Scott, J, Shu, X-O, van der Harst, P, Wagenknecht, L E, Wang, J-S, Wang, Y X, Wareham, N, Watkins, H, Weir, D R, Wickremasinghe, A R, Wu, T, Zeggini, E, Zheng, W, Bouchard, C, Evans, M K, Gudnason, V, Kardia, S L R, Liu, Y, Psaty, B M, Ridker, P M, Van Dam, R M, Hayward, C, van Duijn, C M, Tai, E-S, Wong, T Y, Loos, R J F, Franceschini, N, Rotter, J I, Zhu, X, Bierut, L J, Gauderman, W J, Rice, K M, Munroe, P B, Morrison, A C, Rao, D C, Rotimi, C N & Cupples, L A 2019, ' Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids ', Nature Genetics, vol. 51, no. 4, pp. 636-648 . https://doi.org/10.1038/s41588-019-0378-y
Bentley, A R, Sung, Y J, Brown, M R, Winkler, T W, Kraja, A T, Ntalla, I, Schwander, K, Chasman, D I, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, C Y, Sim, X, Vojinovic, D, Huffman, J E, Musani, S K, Li, C, Feitosa, M F, Richard, M A, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, T M, Ding, J, Dorajoo, R, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, Hartwig, F P, He, M, Horimoto, A R V R, Hsu, F C, Christensen, K, Wang, J S, Understanding Society Scientific Group, Lifelines Cohort, COGENT-Kidney Consortium & EPIC-InterAct Consortium 2019, ' Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids ', Nature Genetics, vol. 51, no. 4, pp. 636-648 . https://doi.org/10.1038/s41588-019-0378-y
COGENT-Kidney Consortium & Morris, A P 2019, ' Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids ', Nature Genetics, vol. 51, no. 4, pp. 636-648 . https://doi.org/10.1038/s41588-019-0378-y
Nature Genetics, 51(4), 636-+. Nature Publishing Group
Nature Genetics, 2019, 51 (4), pp.636-648. ⟨10.1038/s41588-019-0378-y⟩
Nature Genetics, 51(4), 636-648. Nature Publishing Group
2019, ' Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids ', Nature Genetics, vol. 51, no. 4, pp. 636-648 . https://doi.org/10.1038/s41588-019-0378-y
Nature genetics

The concentrations of high- and low-density lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5177e19ad850477c3c810e7883a94b85
http://ora.ox.ac.uk/objects/uuid:

Appetite control by the tongue-gut axis and evaluation of the role of CD36/SR-B2

Autor: Philippe Besnard, I. Niot

Publikováno v: Biochimie
Biochimie, Elsevier, 2017, 136, pp.27-32. 〈http://www.sciencedirect.com/science/article/pii/S0300908417300421〉. 〈10.1016/j.biochi.2017.02.011〉
Biochimie, Elsevier, 2017, 136, pp.27-32. ⟨10.1016/j.biochi.2017.02.011⟩

IF 3.112; International audience; Understanding the mechanisms governing food intake is a public health issue given the dramatic rise of obesity over the world. The overconsumption of tasty energy-dense foods rich in lipids is considered to be one of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c414eaef01ae9c246655278f7b1ad6c2
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01540388