Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens

Autor: Normand, Sylvain, Waldschmitt, Nadine, Neerincx, Andreas, Martinez-Torres, Ruben Julio, Chauvin, Camille, Couturier-Maillard, Aurelie, Boulard, Olivier, Cobret, Laetitia, Awad, Fawaz, Huot, Ludovic, Ribeiro-Ribeiro, Andre, Lautz, Katja, Ruez, Richard, Delacre, Myriam, Bondu, Clovis, Guilliams, Martin, Scott, Charlotte, Segal, Anthony, Amselem, Serge, Hot, David, Karabina, Sonia, Bohn, Erwin, Ryffel, Bernhard, Poulin, Lionel F, Kufer, Thomas A, Chamaillard, Mathias

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications, 2018, 9, pp.5338. ⟨10.1038/s41467-018-07750-5⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-07750-5⟩
Nature Communications, Nature Publishing Group, 2018, 9, pp.5338. ⟨10.1038/s41467-018-07750-5⟩
NATURE COMMUNICATIONS

Mutations in the nucleotide-binding oligomerization domain protein 12 (NLRP12) cause recurrent episodes of serosal inflammation. Here we show that NLRP12 efficiently sequesters HSP90 and promotes K48-linked ubiquitination and degradation of NOD2 in r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e50944fc482415c00f8748ca8a1bb1ad
http://link.springer.com/article/10.1038/s41467-018-07750-5

FHL1 is a key player of chikungunya virus tropism and pathogenesis

Autor: Beate M. Kümmerer, Laura Pezzi, Mohamed Lamine Hafirassou, Lucie Gueneau, Constance Delaugerre, Gisèle Bonne, Thibaud Goupil, Vasiliya Kril, Monsef Benkirane, Julien Burlaud-Gaillard, Lucie Bonnet-Madin, R. Juntas-Morales, Anne Bertrand Legout, Thérèse Couderc, Laurent Meertens, Etienne Simon-Loriere, Philippe Roingeard, Ali Amara, Marc Lecuit, Rabah Ben Yaou, Sophia Rafasse, Alexis Brugier, Xavier de Lamballerie, Pierre-Olivier Vidalain, Cécile Doyen, Athena Labeau

Publikováno v: Comptes Rendus Biologies
Comptes Rendus Biologies, 2020, 343 (4), pp.79-89. ⟨10.5802/crbiol.40⟩
Comptes Rendus Biologies, Elsevier, 2020, 343 (4), pp.79-89. ⟨10.5802/crbiol.40⟩

Chikungunya is an infectious disease caused by the chikungunya virus (CHIKV), an alphavirus transmitted to humans by Aedes mosquitoes, and for which there is no licensed vaccine nor antiviral treatments. By using a loss-of-function genetic screen, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350748b1a4b8046cc108abbcc5a794aa
https://hal-pasteur.archives-ouvertes.fr/pasteur-03246117/document

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

Autor: Tarja Schröder, Matteo Pedrelli, Luc Van Gaal, Anthony N. Hollenberg, Arturo Mendoza, Philippe Lefebvre, Ning Liang, Saioa Goñi, Zhiqiang Huang, Bart Staels, Raoul Kuiper, Paolo Parini, Serena Barilla, Lise Lotte Vedin, Eckardt Treuter, Nicolas Venteclef, Sven Francque, Tomas Jakobsson, Anastasius Damdimopoulos, Marco Giudici, Rongrong Fan, Fawaz Alzaid, Osman Ahmed

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.1684. ⟨10.1038/s41467-019-09524-z⟩
Nature Communications, 2019, 10 (1), pp.1684. ⟨10.1038/s41467-019-09524-z⟩
Nature communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations of regulatory transcription networks and epigenomes in hepatocytes. Here we demonstrate that G protein pathway suppressor 2 (GPS2), a subunit of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda4f2121737c067e7c9c5471aeeb6a3
https://www.hal.inserm.fr/inserm-02154801/document

Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)

Autor: Pierre Bordigoni, Danielle Canioni, Michèle Milili, Nathalie Lambert, Claire Galambrun, Marie Ouachée-Chardin, Filomeen Haerynck, Françoise Le Deist, Despina Moshous, Christelle Lenoir, Stephanie Rigaud, Lionel Galicier, Fabien Touzot, Capucine Picard, Mohamed Hamidou, Hirokazu Kanegane, Ester Mejstrikova, Helen Chapel, Eduardo López-Granados, Stéphane Blanche, Alain Dabadie, Jana Pachlopnik Schmid, Pierre-Simon Rohrlich, Fabian Hauck, Geneviève de Saint Basile, Claudin Schiff, Jean-Louis Stephan, Alain Fischer, Isabelle Pellier, Nizar Mahlaoui, Sylvain Latour, Alain Fourmaintraux, Vincent Barlogis

Publikováno v: Blood
Blood, American Society of Hematology, 2011, 117 (5), pp.1522-9. ⟨10.1182/blood-2010-07-298372⟩
Blood, 2011, 117 (5), pp.1522-9. ⟨10.1182/blood-2010-07-298372⟩
Blood; Vol 117
Blood, American Society of Hematology, 2011, 117 (5), pp.1522-9. 〈10.1182/blood-2010-07-298372〉

X-linked lymphoproliferative syndromes (XLP) are primary immunodeficiencies characterized by a particular vulnerability toward Epstein-Barr virus infection, frequently resulting in hemophagocytic lymphohistiocytosis (HLH). XLP type 1 (XLP-1) is cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe9d22dee92c4a2e0ddda891a9b2537
https://doi.org/10.1182/blood-2010-07-298372

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response

Autor: Yamina Bennasser, Monsef Benkirane, Sonia Amraoui, Mehdi Morchikh, Julien Cau, Dany Severac, Olivier Schwartz, Alexandra Cribier, Raoul Raffel, Emeric Dubois

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2017, 67 (3), pp.387-399. ⟨10.1016/j.molcel.2017.06.020⟩
Molecular Cell, 2017, 67 (3), pp.387-399. ⟨10.1016/j.molcel.2017.06.020⟩

International audience; The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry, and RNA sequencing to identify a ribonuclear complex built around

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208cc4f7ee7b022c7835ffde112ee824
https://hal.archives-ouvertes.fr/hal-01572350