Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome

Autor: Sophie Georgin-Lavialle, Philipp Starkl, Eva Conde, Thomas Marichal, Axel Roers, Hal M. Hoffman, Bianca Balbino, Lori Broderick, Julien Stackowicz, Stephen J. Galli, Laurent L. Reber, Nicolas Gaudenzio, Friederike Jönsson, Pierre Bruhns, Nadine Serhan, Philippe Moguelet, Ophélie Godon

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, 2021, 218 (10), pp.e20201466. ⟨10.1084/jem.20201466⟩

International audience; Gain-of-function mutations in NLRP3 are responsible for a spectrum of autoinflammatory diseases collectively referred to as “cryopyrin-associated periodic syndromes” (CAPS). Treatment of CAPS patients with IL-1–targeted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9915e1239305d8535688510613820f
https://pubmed.ncbi.nlm.nih.gov/34477811

Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2

Autor: Jeremy Goc, Gregory G. Putzel, Hiroki Kabata, Judith R. Kelsen, Manish A. Shah, Endi K. Santosa, Gérard Eberl, Gregory F. Sonnenberg, Coco Chu, Kendall A. Smith, Fei Teng, Lei Zhou, Robbyn Sockolow, Robert N. Baldassano, Nicholas J. Bessman, Eric Vivier

Publikováno v: Nature
Nature, 2019, 568 (7752), pp.405-409. ⟨10.1038/s41586-019-1082-x⟩
Nature, Nature Publishing Group, 2019, 568 (7752), pp.405-409. ⟨10.1038/s41586-019-1082-x⟩

International audience; Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract 1-4. The protective effects of IL-2 involve the generation, maintenance and function of regulatory T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b74b95cc1414507458227043fc6212
https://hal-pasteur.archives-ouvertes.fr/pasteur-03258606

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

Autor: Mihai G. Netea, Peter Aaby, Jessica Quintin, Joke van Loenhout, Johanneke Kleinnijenhuis, Jos W. M. van der Meer, Leo A. B. Joosten, Christine Stabell Benn, Frank Preijers, Reinout van Crevel, Cor Jacobs, Ramnik J. Xavier

Publikováno v: Kleinnijenhuis, J, Quintin, J, Preijers, F, Benn, C S, Joosten, L A B, Jacobs, C, van Loenhout, J, Xavier, R J, Aaby, P, van der Meer, J W M, van Crevel, R & Netea, M G 2013, ' Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity ', Journal of Innate Immunity, vol. 37, no. 9, pp. 1041–1045 . https://doi.org/10.1159/000355628
Journal of Innate Immunity
Journal of Innate Immunity, Karger, 2014, 6 (2), pp.152-158. ⟨10.1159/000355628⟩
Journal of Innate Immunity, 6, 2, pp. 152-8
Journal of Innate Immunity, 6, 152-8

Contains fulltext : 138552.pdf (Publisher’s version ) (Open Access) We have recently shown that BCG (Bacillus Calmette-Guerin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11106bbbab3561efbf3a4d42ce73ddb5
https://hdl.handle.net/2066/138552

Aspergillus Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-gamma Receptor/Syk/PI3K Pathway

Autor: Mihai G. Netea, Katharina L. Becker, Leo A. B. Joosten, Mark S. Gresnigt, X. Wang, Anne Ammerdorffer, Roel P. Gazendam, Jean-Paul Latgé, F.L. van de Veerdonk, Cor Jacobs, Vishukumar Aimanianda

Publikováno v: Mbio, 7, 3, pp. pii: e01823-15-pii: e01823-15
mBio
mBio, 7(3), e01823-15. American Society for Microbiology
mBio, 2016, 7 (3), ⟨10.1128/mBio.01823-15⟩
Mbio, 7, pii: e01823-15-pii: e01823-15
mBio, Vol 7, Iss 3, p e01823-15 (2016)
mBio, American Society for Microbiology, 2016, 7 (3), ⟨10.1128/mBio.01823-15⟩
mBio, Vol 7, Iss 3 (2016)

Chitin is an important cell wall component of Aspergillus fumigatus conidia, of which hundreds are inhaled on a daily basis. Previous studies have shown that chitin has both anti- and proinflammatory properties; however the exact mechanisms determini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac107bf32ad7d52da47381625e1c3c0
https://hdl.handle.net/2066/171693

A role for specific collagen motifs during wound healing and inflammatory response of fibroblasts in the teleost fish gilthead seabream

Autor: Dominique Bihan, Patricia Castillo-Briceño, Victoriano Mulero, Richard W. Farndale, Alfonsa García-Ayala, José Meseguer, Samir W. Hamaia, Michael Nilges

Publikováno v: Molecular Immunology
Molecular Immunology, 2011, 48, pp.826-34. ⟨10.1016/j.molimm.2010.12.004⟩
Molecular Immunology, Elsevier, 2011, 48, pp.826-34. ⟨10.1016/j.molimm.2010.12.004⟩

International audience; Specific sites and sequences in collagen to which cells can attach, either directly or through protein intermediaries, were identified using Toolkits of 63-amino acid triple-helical peptides and specific shorter GXX'GEX″ mot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4076f14b66af88603c935a5e1d349f32
https://doi.org/10.1016/j.molimm.2010.12.004