Differential Inhibition of HIV Replication by the 12 Interferon Alpha Subtypes

Autor: Olivia Blake, Arnaud Droit, Alexandre Nicolas, Jérôme Estaquier, Alexandra Tauzin, Armando Espinosa Ortiz, Jacques Dutrieux, Calaiselvy Soundaramourty, Fabrizio Mammano, Charles Joly-Beauparlant

Publikováno v: Journal of Virology
Journal of Virology, 2021, 95 (15), pp.e0231120. ⟨10.1128/JVI.02311-20⟩
J Virol
Journal of Virology, American Society for Microbiology, 2021, 95 (15), pp.e0231120. ⟨10.1128/JVI.02311-20⟩

International audience; Type I interferons (IFNs) are a family of cytokines that represent a first line of defense against virus infections. The 12 different IFN-α subtypes share a receptor on target cells and trigger similar signaling cascades. Sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2043d318193f130e04b6e434b3ee6a22
https://www.hal.inserm.fr/inserm-03451787/document

Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies

Autor: Madelain, Vincent, Baize, Sylvain, Jacquot, Frédéric, Reynard, Stéphanie, Fizet, Alexandra, Barron, Stephane, Solas, Caroline, Lacarelle, Bruno, Carbonnelle, Caroline, Mentré, France, Raoul, Hervé, de Lamballerie, Xavier, Guedj, Jérémie

Publikováno v: Nature Communications
Nature Communications, 2018, 9 (1), pp.4013. ⟨10.1038/s41467-018-06215-z⟩
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, Nature Publishing Group, 2018, 9, ⟨10.1038/s41467-018-06215-z⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.4013. ⟨10.1038/s41467-018-06215-z⟩

Despite several clinical trials implemented, no antiviral drug could demonstrate efficacy against Ebola virus. In non-human primates, early initiation of polymerase inhibitors favipiravir and remdesivir improves survival, but whether they could be ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d154ac0e471157d76dc4db477c6eb882
https://hal-pasteur.archives-ouvertes.fr/pasteur-03236192/document

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Autor: Llibre, Alba, Bondet, Vincent, Rodéro, Mathieu, Hunt, David, Crow, Yanick, Duffy, Darragh

Publikováno v: Journal of Visualized Experiments : JoVE
Llibre, A, Bondet, V, Rodero, M P, Hunt, D, Crow, Y J & Duffy, D 2018, ' Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α ', Journal of Visualized Experiments (JoVE), no. 136 . https://doi.org/10.3791/57421
Journal of visualized experiments : JoVE
Journal of visualized experiments : JoVE, 2018, 136, pp.e57421. ⟨10.3791/57421⟩
Journal of visualized experiments : JoVE, JoVE, 2018, pp.e57421. ⟨10.3791/57421⟩

International audience; The main aim of this protocol is to describe the development and validation of an interferon (IFN)-α single molecule array digital Enzyme-Linked ImmunoSorbent Assay (ELISA) assay. This system enables the quantification of hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::baf0361d59b18e81ef8a250bc8750c71
https://pubmed.ncbi.nlm.nih.gov/29985347

Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors

Autor: Umeshree Govender, Frédérique Michel, Yasmine Bourdache, Sandra Pellegrini, Béatrice Corre

Publikováno v: Journal of Leukocyte Biology
Journal of Leukocyte Biology, Society for Leukocyte Biology, 2017, 101 (5), pp.1181-1190. ⟨10.1189/jlb.2A0416-187RR⟩
Journal of Leukocyte Biology, 2017, 101 (5), pp.1181-1190. ⟨10.1189/jlb.2A0416-187RR⟩

Type I IFN can exert pro- and anti-inflammatory activities in the immune system. Here, we have investigated the mechanism by which IFN-α enhances early expression of the anti-inflammatory cytokine IL-10 in human CD45RA+CD4+ T cells. With the use of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2464e50cc98856b4358c2ff846e243
https://hal-pasteur.archives-ouvertes.fr/pasteur-02136992

Erroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics

Autor: Caval, Mohamed S. Bouzidi, Jean-Pierre Vartanian, Michel Henry, Rodolphe Suspène, Simon Wain-Hobson

Publikováno v: British Journal of Cancer
British Journal of Cancer, 2014, 110 (10), pp.2615-2622. ⟨10.1038/bjc.2014.176⟩

International audience; Background: The revolution in cancer genomics shows that the dominant mutations are CG->TA transitions. The sources of these mutations are probably two host cell cytidine deaminases APOBEC3A and APOBEC3B. The former in particu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfee682b49b4e289cb39e5876039f22
http://europepmc.org/articles/PMC4021520