Výsledky vyhledávání - "MESH : Indoles"

Real-world safety profiles of pirfenidone and nintedanib in idiopathic pulmonary fibrosis patients

Autor: Dorine Fournier, Stéphane Jouneau, Guillaume Bouzillé, Elisabeth Polard, Marie-Noëlle Osmont, Lucie-Marie Scailteux

Publikováno v: Pulmonary Pharmacology and Therapeutics
Pulmonary Pharmacology and Therapeutics, 2022, 76, pp.102149. ⟨10.1016/j.pupt.2022.102149⟩
Annual Meeting of French Society of Pharmacology and Therapeutics
Annual Meeting of French Society of Pharmacology and Therapeutics, Jun 2022, Lille, France. 36, pp.77-78, 2022

Introduction: While pirfenidone and nintedanib have greatly influenced the treatment of idiopathic pulmonary fibrosis (IPF), both drugs have significant early adverse drug reactions (ADRs) and almost nothing is known of their rare and delayed ADRs. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f463e5ba0ebf3d17710bd8bdd4015b
https://univ-rennes.hal.science/hal-03954444/document

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Multicenter phase II trial of nintedanib plus docetaxel in second-line treatment in advanced non-squamous non-small cell lung cancer patients refractory to first-line platin-based chemotherapy (REFRACT GFPC 02–15 study)

Autor: Gwenaelle Le Garff, Margaux Geier, Lionel Falchero, Jean-Bernard Auliac, A. Bizieux, Alain Vergnenegre, Charles Ricordel, Florian Guisier, Laurent Greillier, Isabelle Monnet, R. Lamy, Refract Gfpc investigators, Christos Chouaid

Publikováno v: Lung Cancer
Lung Cancer, 2021, 161, pp.122-127. ⟨10.1016/j.lungcan.2021.09.007⟩
Lung Cancer, Elsevier, 2021, 161, pp.122-127. ⟨10.1016/j.lungcan.2021.09.007⟩

Introduction Advanced non-squamous non-small cell lung cancer (NsqNSCLC) progressing at the induction of a first-line of platin-based chemotherapy is a subgroup of patients with poor prognosis and few second-line treatment options. Materials and Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1b9fe5d0e6dc748f9ad0dda55f243d
https://hal.inria.fr/hal-03524385

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EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness

Autor: Bruno Ragazzon, Jean-Christophe Pointud, Houda Tabbal, Pierre Val, Igor Tauveron, Coralie Drelon, M. Batisse-Lignier, Cyril Djari, Stéphanie Rodriguez, Anne-Marie Lefrançois-Martinez, Amandine Septier, Jérôme Bertherat, Guillaume Assié, Isabelle Sahut-Barnola, Mickael Mathieu, Antoine Martinez

Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
British Journal of Cancer, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩

International audience; BACKGROUND: EZH2 is overexpressed and associated with poor prognosis in adrenocortical carcinoma (ACC) and its inhibition reduces growth and aggressiveness of ACC cells in culture. Although EZH2 was identified as the methyltra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e8aeb4b82b5deb9b1796239f7afa18
https://doi.org/10.1038/s41416-019-0538-y

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Sex differences in the GSK3β-mediated survival of adherent leukemic progenitors

Autor: Jessica Bertrand, Bernard Payrastre, N Gallay, Nathalie Vergnolle, Véronique Maguer-Satta, Mathieu Despeaux, Cécile Demur, Ezzeddine Bourogaa, S Joly, P Bonnevialle, F Louache, Claire Racaud-Sultan

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2012, 31 (6), pp.694-705. 〈10.1038/onc.2011.258〉
Oncogene, Nature Publishing Group, 2012, 31 (6), pp.694-705. ⟨10.1038/onc.2011.258⟩

International audience; Therapeutic resistance of acute myeloid leukemia stem cells, enriched in the CD34(+)38(-)123(+) progenitor population, is supported by extrinsic factors such as the bone marrow niche. Here, we report that when adherent onto fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d4a2f208c4080faac4382098e8472e
https://doi.org/10.1038/onc.2011.258

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Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK)

Autor: Hossam M. Draz, Alexander A. Goldberg, J. Thomas Sanderson, Stephen Safe, Vladimir I. Titorenko, Emma S. Tomlinson Guns

Publikováno v: Cellular Signalling
Cellular Signalling, Elsevier, 2017, 40, pp.172-182. ⟨10.1016/j.cellsig.2017.09.006⟩

International audience; 3,3'-Diindolylmethane (DIM) and its synthetic halogenated derivatives 4,4'-Br2- and 7,7'-Cl2DIM (ring-DIMs) have recently been shown to induce protective autophagy in human prostate cancer cells. The mechanisms by which DIM an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7331239d2af63ac200a47891a978e8b
https://hal-riip.archives-ouvertes.fr/pasteur-01854432

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mGlu1 receptor canonical signaling pathway contributes to the opening of the orphan GluD2 receptor

Autor: Selma Dadak, Elise Goyet, Nathalie Bouquier, Carole Levenes, Laurent Fagni, Julie Perroy

Publikováno v: Neuropharmacology
Neuropharmacology, Elsevier, 2017, 115, pp.92-99. ⟨10.1016/j.neuropharm.2016.06.001⟩

International audience; The orphan Glutamate receptor Delta2 (GluD2) intrinsic ion channel activity is indirectly triggered by glutamate through stimulation of the metabotropic glutamate receptor 1 (mGlu1), in cerebellar Purkinje cells. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e81109bd037540b03d7a019764b76ad
https://hal.archives-ouvertes.fr/hal-03109591

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Acute activation of cannabinoid receptors by anandamide reduces gastrointestinal motility and improves postprandial glycemia in mice

Autor: Stephanie Troy-Fioramonti, Laurent Demizieux, Joseph Gresti, Tania Muller, Bruno Vergès, Pascal Degrace

Publikováno v: Diabetes
Diabetes, American Diabetes Association, 2015, 64 (3), pp.808-18. ⟨10.2337/db14-0721⟩
Diabetes, American Diabetes Association, 2015, 64 (3), pp.808-18. 〈10.2337/db14-0721〉

International audience; The endocannabinoid system (ECS) is associated with an alteration of glucose homeostasis dependent on cannabinoid receptor-1 (CB1R) activation. However, very little information is available concerning the consequences of ECS a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e025a03b2eaffb58d5ca253aa302691
https://www.hal.inserm.fr/inserm-01344501

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5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms

Autor: Andrea Medeiros, Laurent Meijer, Nadège Loaëc, Oliver Koch, Ricarda S. Korn, Lutz Preu, Conrad Kunick, Marcelo A. Comini, Diego Benítez, Oliver C.F. Orban

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2016, 24 (16), pp.3790-800. ⟨10.1016/j.bmc.2016.06.023⟩

International audience; Trypanothione synthetase is an essential enzyme for kinetoplastid parasites which cause highly disabling and fatal diseases in humans and animals. Inspired by the observation that N(5)-substituted paullones inhibit the trypano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e4e9673479b0f5057fd3ad369138d5
https://hal-riip.archives-ouvertes.fr/pasteur-01499026

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Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues : A novel DYRK1A inhibitor class

Autor: Frédéric Buron, Emeline Vedrenne, Cleopatra Neagoie, Olivier Lozach, Laurent Meijer, Stéphane Bourg, Sorin Rosca, Amélie Lansiaux, Sylvain Routier, Brigitte Baldeyrou, Jean-Yves Mérour

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2012, 49, pp.379-96. ⟨10.1016/j.ejmech.2012.01.040⟩
European Journal of Medicinal Chemistry, Elsevier, 2012, 49, pp.379-96. ⟨10.1016/j.ejmech.2012.01.040⟩
European Journal of Medicinal Chemistry, Elsevier, 2012, 49, pp.379-396. ⟨10.1016/j.ejmech.2012.01.040⟩

International audience; A library of substituted chromeno[3,4-b]indoles was developed as Lamellarin isosters. Synthesis was achieved from indoles after a four-step pathway sequence involving C-3 iodination, a Suzuki cross-coupling reaction, and a one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4320509b2a76082675976c07f0489bdb
https://doi.org/10.1016/j.ejmech.2012.01.040

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Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents

Autor: Olga N. Burchak, Jean-Noel Denis, Max Maurin, Carmela Giglione, Xavier Guinchard, Claude Jolivalt, Laure Maigre, Emmanuelle Le Pihive, Dominique Schneider, Pascale Bouhours, Jean-Marc Paris, Thierry Meinnel

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2011, 19 (10), pp.3204-15. ⟨10.1016/j.bmc.2011.03.060⟩

International audience; A collection of 3-substituted indole derivatives was prepared using nucleophilic addition of indoles to nitrones. The compounds were then tested for their antibacterial activity against almost thirty bacterial strains represen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372f094f373deac49f7ed20a89ea06a7
https://doi.org/10.1016/j.bmc.2011.03.060

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