Výsledky vyhledávání - "MESH : Immunoglobulin Variable Region"

Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+IgD+CD27+ B cell repertoire in infants

Autor: Maria Mamani-Matsuda, Frédéric Gauthier, Claude-Agnès Reynaud, Corinne Cordier, Capucine Picard, Damiana Lecoeuche, Jean-Claude Weill, Sandra K. Weller

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2008, 205 (6), pp.1331-42. ⟨10.1084/jem.20071555⟩
The Journal of Experimental Medecine
The Journal of Experimental Medecine, The Rockefeller University Press, 2008, 205 (6), pp.1331-42. 〈10.1084/jem.20071555〉
Journal of Experimental Medicine, 2008, 205 (6), pp.1331-42. ⟨10.1084/jem.20071555⟩

International audience; T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0931002431ee87e4ab64c257748949
http://europepmc.org/articles/PMC2413031

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The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells

Autor: Alexis Saintamand, Yves Denizot, Michel Cogné, Christelle Vincent-Fabert, Bernardo Reina-San-Martin, Pauline Rouaud, Isabelle Robert, Rémi Fiancette, Eric Pinaud, Marie Marquet

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2013, 210 (8), pp.1501-7. ⟨10.1084/jem.20130072⟩

Somatic hypermutation in variable heavy chain rearranged regions is abrogated in the absence of the 3′ regulatory region enhancer, whereas transcription rate in the Ig heavy chain is only partially reduced.
Interactions with cognate antigens r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80c73517706ccf8515835fcf135780f
https://doi.org/10.1084/jem.20130072

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Primary cystic lung light chain deposition disease: a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34/IGKV1 receptor

Autor: Marc Stern, Marie-Hélène Delfau-Larue, Hervé Mal, Diane Damotte, Magali Colombat, Michel Fournier, Patrice Callard, Jacques Diebold, Jean-Pierre Farcet, Christiane Copie-Bergman

Publikováno v: Blood
Blood, American Society of Hematology, 2008, 112 (5), pp.2004-12. 〈10.1182/blood-2007-11-123596〉

We have recently described a new form of light chain deposition disease (LCDD) presenting as a severe cystic lung disorder requiring lung transplantation. There was no bone marrow plasma cell proliferation. Because of the absence of disease recurrenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b121f36a9399468ebcd762f01ba3763
https://doi.org/10.1182/blood-2007-11-123596

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Multicenter study of ZAP-70 expression in patients with B-cell chronic lymphocytic leukemia using an optimized flow cytometry method

Autor: Gachard, Nathalie, Salviat, Aurélie, Boutet, Catherine, Arnoulet, Christine, Durrieu, Françoise, Lenormand, Bernard, Leprêtre, Stéphane, Olschwang, Sylviane, Jardin, Fabrice, Lafage-Pochitaloff, Marina, Penther, Dominique, Sainty, Danielle, Reminieras, Liliane, Feuillard, Jean, Béné, Marie C, Renseigné, Non

Publikováno v: Haematologica
Haematologica, Ferrata Storti Foundation, 2008, 93 (2), pp.215-23. ⟨10.3324/haematol.11622⟩
Haematologica, 2008, 93 (2), pp.215-23. ⟨10.3324/haematol.11622⟩

International audience; BACKGROUND: Flow cytometry allows specific assessment of the expression of ZAP-70, a promising new prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL), but suffers from a lack of multicenter standardization. DESIG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5548def8efd75a1ffedcb27695a98c
https://doi.org/10.3324/haematol.11622

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Protein-protein recognition and interaction hot spots in an antigen-antibody complex: Free energy decomposition identifies 'efficient amino acids'

Autor: Virginie Lafont, Danièle Altschuh, Michael Schaefer, Annick Dejaegere, Roland H. Stote

Publikováno v: Proteins-Structure, Function and Bioinformatics
Proteins-Structure, Function and Bioinformatics, Wiley, 2007, 67 (2), pp.418-34. ⟨10.1002/prot.21259⟩

The molecular mechanics Poisson–Boltzmann surface area (MM/PBSA) method was applied to the study of the protein–protein complex between a camelid single chain variable domain (cAb-Lys3) and hen egg white lysozyme (HEL), and between cAb-Lys3 and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d49abab820f6fd8c7fba2b65f2307d
https://doi.org/10.1002/prot.21259

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Quantitative measurement of protein stability from unfolding equilibria monitored with the fluorescence maximum wavelength

Autor: Elodie Monsellier, Hugues Bedouelle

Publikováno v: Protein Engineering, Design and Selection
Protein Engineering, Design and Selection, Oxford University Press (OUP), 2005, 18 (9), pp.445-56. ⟨10.1093/protein/gzi046⟩
Protein Engineering, Design and Selection, 2005, 18 (9), pp.445-56. ⟨10.1093/protein/gzi046⟩

International audience; The fluorescence of tryptophan is used as a signal to monitor the unfolding of proteins, in particular the intensity of fluorescence and the wavelength of its maximum lambda(max). The law of the signal is linear with respect t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c9ab0e0f07bc47d031507bc51f909f
https://doi.org/10.1093/protein/gzi046

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Fanconi’s syndrome induced by a monoclonal Vκ3 light chain in Waldenström’s macroglobulinemia

Autor: Jean-Michel Goujon, Antoine Thierry, Ramzi Abou-Ayache, Nathalie Quellard, Frank Bridoux, Michel Cogné, Guy Touchard, Christophe Sirac, Valerie Hugue, Catherine Decourt

Publikováno v: American Journal of Kidney Diseases
American Journal of Kidney Diseases, Elsevier, 2005, 45 (4), pp.749-57. ⟨10.1053/j.ajkd.2004.12.020⟩

Fanconi's syndrome (FS) is a disorder of sodium-dependent proximal tubule reabsorption, which may complicate plasma cell disorders producing a free monoclonal light chain (LC). FS often occurs in the setting of smoldering myeloma and features cytopla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089db7d8b1ca4734a7a12178a84c1044
https://doi.org/10.1053/j.ajkd.2004.12.020

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Intrabody expression in eukaryotic cells

Autor: Pierre Martineau, Laurence Guglielmi

Publikováno v: Methods in Molecular Biology ISBN: 9781603273015
Methods in Molecular Biology
Methods in Molecular Biology, Humana Press/Springer Imprint, 2009, 562, pp.195-203. ⟨10.1007/978-1-60327-302-2_15⟩
Methods in Molecular Biology (Clifton then Totova)
Methods in Molecular Biology (Clifton then Totova), Humana Press (Springer Imprint), 2009, 562, pp.195-203. 〈10.1007/978-1-60327-302-2_15〉

International audience; We describe procedures for intracellular expression of scFv in eukaryotic cells. Starting from a scFv gene cloned in a phage-display vector, we describe the cloning step into a mammalian expression vector, the transient transf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b42d02d2ff30e195872dc73b71ee89c
https://pubmed.ncbi.nlm.nih.gov/19554297

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Immunoglobulin genes undergo legitimate repair in human B cells not only after cis- but also frequent trans-class switch recombination

Autor: Sylvia M. Bardet, Michel Cogné, Brice Laffleur, M Brousse, A Baylet, Armand Garot

Publikováno v: Genes and Immunity
Genes and Immunity, Nature Publishing Group: Open Access Hybrid Model Option B, 2014, 15 (5), pp.341-6. ⟨10.1038/gene.2014.25⟩

International audience; Immunoglobulin (Ig) genes specifically recruit activation-induced deaminase (AID) for 'on-target' DNA deamination, initiating either variable (V) region somatic hypermutation, or double-strand break intermediates of class swit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f7c8160d6a667d91df65432999dfab
https://hal.archives-ouvertes.fr/hal-01112042

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The Eμ enhancer region influences H chain expression and B cell fate without impacting IgVH repertoire and immune response in vivo

Autor: Marie Marquet, Claire Carrion, Pauline Rouaud, Sébastien Bender, Armand Garot, Sandrine Lecardeur, Yves Denizot, Michel Cogné, Eric Pinaud

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2014, 193 (3), pp.1171-83. ⟨10.4049/jimmunol.1302868⟩

The IgH intronic enhancer region Eμ is a combination of both a 220-bp core enhancer element and two 310–350-bp flanking scaffold/matrix attachment regions named MARsEμ. In the mouse, deletion of the core-enhancer Eμ element mainly affects VDJ re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4a398d25b4b24927afdee61f9540be
https://pubmed.ncbi.nlm.nih.gov/24965776

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