Zobrazeno 1 - 10 of 47 pro vyhledávání: '"MESH : Immunoglobulin Heavy Chains"'
1
Identification of novel recurrent ETV6-IgH fusions in primary central nervous system lymphoma
Autor: Dominique Figarella-Branger, Franck Bielle, Clovis Adam, Louis Royer-Perron, Guillaume Gauchotte, David Meyronet, Aurélie Bruno, Chiara Villa, Amithys Rahimian, Blandine Boisselier, Carole Soussain, Fabrice Chrétien, Khê Hoang-Xuan, Caroline Houillier, Sandrine Eimer, Mailys Daniau, Frederic Davi, Karima Mokhtari, Karim Labreche, Justine Guegan, Pierre de la Grange, Agusti Alentorn, Marc Polivka, Audrey Rousseau, Frédéric Lemoine
Publikováno v: Neuro-Oncology
Neuro-Oncology, 2018, 20 (8), pp.1092-1100. ⟨10.1093/neuonc/noy019⟩
Neuro-Oncology, Oxford University Press (OUP), 2018, 20 (8), pp.1092-1100. ⟨10.1093/neuonc/noy019⟩
International audience; Background: Primary central nervous system lymphoma (PCNSL) represents a particular entity within non-Hodgkin lymphomas and is associated with poor outcome. The present study addresses the potential clinical relevance of chime
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cc9f95aaa08e9662341fc6bbe9c176
https://hal-pasteur.archives-ouvertes.fr/pasteur-02862388
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2
The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells
Autor: Alexis Saintamand, Yves Denizot, Michel Cogné, Christelle Vincent-Fabert, Bernardo Reina-San-Martin, Pauline Rouaud, Isabelle Robert, Rémi Fiancette, Eric Pinaud, Marie Marquet
Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2013, 210 (8), pp.1501-7. ⟨10.1084/jem.20130072⟩
Somatic hypermutation in variable heavy chain rearranged regions is abrogated in the absence of the 3′ regulatory region enhancer, whereas transcription rate in the Ig heavy chain is only partially reduced.
Interactions with cognate antigens r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80c73517706ccf8515835fcf135780f
https://doi.org/10.1084/jem.20130072
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3
Enhancers Located in Heavy Chain Regulatory Region (hs3a, hs1,2, hs3b, and hs4) Are Dispensable for Diversity of VDJ Recombination
Autor: Michel Cogné, Yves Denizot, Christelle Vincent-Fabert, Pauline Rouaud, Eric Pinaud, Rémi Fiancette
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (11), pp.8356-60. ⟨10.1074/jbc.M112.341024⟩
International audience; V(D)J recombination occurs during the antigen-independent early steps of B-cell ontogeny. Multiple IgH cis-regulatory elements control B-cell ontogeny. IGCR1 (intergenic control region 1), the DQ52 promoter/enhancer, and the i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9abeeb4745a12efd0b4e4e00ca2a443
https://doi.org/10.1074/jbc.m112.341024
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4
A p53 Defect Sensitizes Various Stages of B Cell Development to Lymphomagenesis in Mice Carrying an IgH 3′ Regulatory Region-Driven c-myc Transgene
Autor: Michel Cogné, Virginie Magnone, Brice Laffleur, Yves Denizot, Pauline Rouaud, Rémi Fiancette, Christelle Vincent-Fabert
Publikováno v: The Journal of Immunology; Vol 187
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2011, 187 (11), pp.5772-82. ⟨10.4049/jimmunol.1102059⟩
Although c-myc is classically described as the driving oncogene in Burkitt’s lymphoma (BL), deregulation and mutations of c-myc have been reported in multiple solid tumors and in other mature B cell malignancies such as mantle cell lymphoma (MCL),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8094820818eb7b8ee1520ce26ef6c1
https://doi.org/10.4049/jimmunol.1102059
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5
A myeloma translocation-like model associating CCND1 with the immunoglobulin heavy-chain locus 3′ enhancers does not promote by itself B-cell malignancies
Autor: Michel Cogné, Yves Denizot, Rémi Fiancette, Christelle Vincent-Fabert, Rada Amin, Nadine Cogné, Véronique Truffinet
Publikováno v: Leukemia Research
Leukemia Research, Elsevier, 2010, 34 (8), pp.1043-51. ⟨10.1016/j.leukres.2009.11.017⟩
International audience; Cyclin D1 overexpression is associated with mantle cell lymphoma and multiple myeloma. In myeloma, it often results from chromosomal translocations linking the CCND1 gene to the 3' part of the IgH locus constant region. This r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259484e9b9657b5481494356bc09d2cf
https://doi.org/10.1016/j.leukres.2009.11.017
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6
Ig Synthesis and Class Switching Do Not Require the Presence of the hs4 Enhancer in the 3′ IgH Regulatory Region
Autor: Michel Cogné, Véronique Truffinet, Christelle Vincent-Fabert, Yves Denizot, Rémi Fiancette, Nadine Cogné
Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2009, 182 (11), pp.6926-32. ⟨10.4049/jimmunol.0900214⟩
Several studies have reported that regulatory elements located 3′ of the IgH locus (namely hs3a, hs1,2, hs3b, and hs4) might play a role during class switch recombination (CSR) and Ig synthesis. While individual deletion of hs3a or hs1,2 had no eff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8412c9a14d20cc8560da8e50cdb21a
https://doi.org/10.4049/jimmunol.0900214
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7
Primary cystic lung light chain deposition disease: a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34/IGKV1 receptor
Autor: Marc Stern, Marie-Hélène Delfau-Larue, Hervé Mal, Diane Damotte, Magali Colombat, Michel Fournier, Patrice Callard, Jacques Diebold, Jean-Pierre Farcet, Christiane Copie-Bergman
Publikováno v: Blood
Blood, American Society of Hematology, 2008, 112 (5), pp.2004-12. 〈10.1182/blood-2007-11-123596〉
We have recently described a new form of light chain deposition disease (LCDD) presenting as a severe cystic lung disorder requiring lung transplantation. There was no bone marrow plasma cell proliferation. Because of the absence of disease recurrenc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b121f36a9399468ebcd762f01ba3763
https://doi.org/10.1182/blood-2007-11-123596
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8
MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation
Autor: Tanja A. Schwickert, Kevin M. McBride, Mila Jankovic, Michel C. Nussenzweig, Thomas Eisenreich, Gordon F. Heidkamp, To-Ha Thai, Davide F. Robbiani, Michela Di Virgilio, Yair Dorsett, Bernardo Reina San-Martin, Anna Gazumyan, Klaus Rajewsky
Publikováno v: Immunity
Immunity, Elsevier, 2008, 28 (5), pp.630-8. ⟨10.1016/j.immuni.2008.04.002⟩
Immunity, 2008, 28 (5), pp.630-8. ⟨10.1016/j.immuni.2008.04.002⟩
International audience; MicroRNAs (miRNAs) are small noncoding RNAs that regulate vast networks of genes that share miRNA target sequences. To examine the physiologic effects of an individual miRNA-mRNA interaction in vivo, we generated mice that car
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9484aee3b6ffa7c023b50153d0ca3b4
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9
Multicenter study of ZAP-70 expression in patients with B-cell chronic lymphocytic leukemia using an optimized flow cytometry method
Autor: Gachard, Nathalie, Salviat, Aurélie, Boutet, Catherine, Arnoulet, Christine, Durrieu, Françoise, Lenormand, Bernard, Leprêtre, Stéphane, Olschwang, Sylviane, Jardin, Fabrice, Lafage-Pochitaloff, Marina, Penther, Dominique, Sainty, Danielle, Reminieras, Liliane, Feuillard, Jean, Béné, Marie C, Renseigné, Non
Publikováno v: Haematologica
Haematologica, Ferrata Storti Foundation, 2008, 93 (2), pp.215-23. ⟨10.3324/haematol.11622⟩
Haematologica, 2008, 93 (2), pp.215-23. ⟨10.3324/haematol.11622⟩
International audience; BACKGROUND: Flow cytometry allows specific assessment of the expression of ZAP-70, a promising new prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL), but suffers from a lack of multicenter standardization. DESIG
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5548def8efd75a1ffedcb27695a98c
https://doi.org/10.3324/haematol.11622
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10
High diversity of the immune repertoire in humanized NOD.SCID.gamma c-/- mice
Autor: Marodon, Gilles, Desjardins, Delphine, Mercey, Laetitia, Baillou, Claude, Parent, Pierric, Manuel, Manuarii, Caux, Christophe, Bellier, Bertrand, Pasqual, Nicolas, Klatzmann, David
Publikováno v: European Journal of Immunology
European Journal of Immunology, 2009, 39 (8), pp.2136-45. ⟨10.1002/eji.200939480⟩
European Journal of Immunology, Wiley-VCH Verlag, 2009, 39 (8), pp.2136-45. ⟨10.1002/eji.200939480⟩
European Journal of Immunology, Wiley-VCH Verlag, 2009, 39 (8), pp.2136-45. 〈10.1002/eji.200939480〉
International audience; The diversity of the human immune repertoire and how it relates to a functional immune response has not yet been studied in detail in humanized NOD.SCID.gammac(-/-) immunodeficient mice. Here, we used a multiplex PCR on genomi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0050ab8fdc2ad5cd709aebd729d11e10
https://hal.science/hal-00420205
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