Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis

Autor: Samuel T Workenhe, Akiko Yanagiya, Huy-Dung Hoang, Soroush Tahmasebi, Dana Pearl, Adrian Pelin, John C. Bell, Chadi Zakaria, Karen L. Mossman, Tyson E. Graber, Jaclyn Hearnden, Polen Sean, Tommy Alain, Jian-Jun Jia, Margaret Watson, Louis-Phillipe Leroux, Seyed Mehdi Jafarnejad, Jean-Simon Diallo, Nahum Sonenberg, Maritza Jaramillo, Nathaniel Robichaud, Vinh Tai Truong, Fabrice Le Boeuf

Publikováno v: Zakaria, C, Sean, P, Hoang, H-D, Leroux, L-P, Watson, M, Workenhe, S T, Hearnden, J, Pearl, D, Truong, V T, Robichaud, N, Yanagiya, A, Tahmasebi, S, Jafarnejad, S M, Jia, J-J, Pelin, A, Diallo, J-S, Le Boeuf, F, Bell, J C, Mossman, K L, Graber, T E, Jaramillo, M, Sonenberg, N & Alain, T 2018, ' Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis ', PLoS Pathogens, vol. 14, no. 8, e1007264 . https://doi.org/10.1371/journal.ppat.1007264
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2018, 14 (8), pp.e1007264. ⟨10.1371/journal.ppat.1007264⟩
PLoS Pathogens, Vol 14, Iss 8, p e1007264 (2018)

International audience; Herpes Simplex Virus 1 (HSV1) is amongst the most clinically advanced oncolytic virus platforms. However, efficient and sustained viral replication within tumours is limiting. Rapamycin can stimulate HSV1 replication in cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c92dee5a0216e1929b4920ce8f0aa3
https://pubmed.ncbi.nlm.nih.gov/30138450

Methylation of Epstein-Barr virus Rta promoter in EBV primary infection, reactivation and lymphoproliferation

Autor: Germi, Raphaële, Guigue, Nicolas, Lupo, Julien, Semenova, Touyana, Grossi, Laurence, Vermeulen, Odile, Epaulard, Olivier, De Fraipont, Florence, Morand, Patrice

Publikováno v: Journal of Medical Virology
Journal of Medical Virology, 2016, 88 (10), pp.1814-1820. ⟨10.1002/jmv.24524⟩
Journal of Medical Virology, Wiley-Blackwell, 2016, 88 (10), pp.1814-1820. ⟨10.1002/jmv.24524⟩

International audience; During Epstein-Barr virus (EBV) latency, the EBV genome is largely silenced by methylation. This silencing is overturned during the switch to the lytic cycle. A key event is the production of the viral protein Zta which binds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::04871f8022cb569fa78e14c7a96e29b4
https://hal.science/hal-02060031

Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis

Autor: Anne Rullier, Nathalie Dugot-Senant, Jean Rosenbaum, Jennifer Gillibert-Duplantier, Gérard Déléris, Cyril Petibois, Pierre Costet, Gaelle Cubel, Valérie Haurie, Paulette Bioulac-Sage, Danièle Taras

Publikováno v: AJP-Gastrointestinal and Liver Physiology
AJP-Gastrointestinal and Liver Physiology, 2008, 294 (1), pp.G226-35. ⟨10.1152/ajpgi.00444.2007⟩

Thrombin inhibition protects against liver fibrosis. However, it is not known whether the thrombin profibrogenic effect is due to effects on blood coagulation or to signaling via protease-activated receptors (PARs). We took advantage of the lack of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d43669519b81c8d6853c718c7987ecf
https://doi.org/10.1152/ajpgi.00444.2007

A novel cell response triggered by interphase centromere structural instability

Autor: Eric Morency, Mirna Sabra, Patrick Lomonte, Frédéric Catez, Pascale Texier

Publikováno v: The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2007, 177 (5), pp.757-68. ⟨10.1083/jcb.200612107⟩

International audience; Interphase centromeres are crucial domains for the proper assembly of kinetochores at the onset of mitosis. However, it is not known whether the centromere structure is under tight control during interphase. This study uses th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a9aae995034596bb9c615b654565a0
https://doi.org/10.1083/jcb.200612107

The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids

Autor: Pier Vincenzo Piazza, Jean-Michel Revest, Aline Desmedt, Françoise Rougé-Pont, Francesco Di Blasi, Pierre Kitchener, François Tronche, Marc Turiault

Publikováno v: Nature Neuroscience
Nature Neuroscience, Nature Publishing Group, 2005, 8, pp.664-672; 835
Nature Neuroscience, Nature Publishing Group, 2005, 8 (5), pp.664-672. ⟨10.1038/nn1441⟩
Nature Neuroscience, 2005, 8 (5), pp.664-672. ⟨10.1038/nn1441⟩

International audience; Many of the behavioral consequences of stress are mediated by the activation of the glucocorticoid receptor by stress-induced high levels of glucocorticoid hormones. To explore the molecular mechanisms of these effects, we com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b15557712b6528bcd7d87141596993b
https://doi.org/10.1038/nn1441