Výsledky vyhledávání - "MESH : Hydroxamic Acids"

An innovative automated active compound screening system allows high-throughput optimization of somatic embryogenesis in Coffea arabica

Autor: Awada, Rayan, Verdier, Dorothée, Froger, Solène, Brulard, Eric, de Faria Maraschin, Simone, Etienne, Hervé, Breton, David

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.810. ⟨10.1038/s41598-020-57800-6⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, 2020, 10 (1), pp.810. ⟨10.1038/s41598-020-57800-6⟩

International audience; Somatic embryogenesis (SE) faces many challenges in fulfilling the growing demand for elite materials. A high-throughput approach is required to accelerate the optimization of SE protocols by multiplying experimental condition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ad560625731b76de1f486cba55a1089c
https://hal.umontpellier.fr/hal-03454869

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A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

Autor: Raymond J. Pierce, Wolfgang Sippl, Julien Lancelot, Karin Schmidtkunz, Alokta Chakrabarti, Dina Robaa, Jelena Melesina, Tajith B. Shaik, Christophe Romier, Conrad V. Simoben, Manfred Jung, Srinivasaraghavan Kannan, Martin Marek

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules; Volume 23; Issue 3; Pages: 566
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩

International audience; A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present study, a docking based virtual screening pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57756972e5c4439f4e393638be3994b
http://europepmc.org/articles/PMC6017931

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HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2

Autor: Fabio Manzo, Sergio Valente, Angela Nebbioso, Antonello Mai, Lucia Altucci, Annamaria Scognamiglio

Publikováno v: Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩

International audience; Discovered for their ability to deacetylate histones and repress transcription, HDACs are a promising target for therapy of human diseases. The class II HDACs are mainly involved in developmental and differentiation processes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a943118e0326db2155e84f6a28e2349e

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HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway

Autor: Fabio Manzo, Hinrich Gronemeyer, Patrick Lutz, Michele Lieb, Pattabhiraman Shankaranarayanan, Raoul Herbrecht, Michael Tsapis

Publikováno v: International Journal of Biochemistry and Cell Biology
International Journal of Biochemistry and Cell Biology, Elsevier, 2007, 39 (7-8), pp.1500-9. ⟨10.1016/j.biocel.2007.03.009⟩

Inhibitors of histone deacetylases (HDACi's) are promising novel tools for cancer therapy. We have compared the growth inhibitory and apoptogenic potential of the pan-HDACi SAHA and the sub-class I selective HDAC inhibitor MS275, as well as valproic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb93f7491a82b5c2ad4d74945cb3c883
https://doi.org/10.1016/j.biocel.2007.03.009

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Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: Chemistry, biological evaluations, and therapeutic prospects

Autor: Brigitte Bauvois, Daniel Dauzonne

Publikováno v: Med Res Rev
Med Res Rev, 2006, 26 (1), pp.88-130. ⟨10.1002/med.20044⟩
Medicinal Research Reviews

Aminopeptidase N (APN)/CD13 (EC 3.4.11.2) is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte). APN/CD13 expression is dysregulated in inflammatory diseases and in canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075702490d771d72776c9df23f654a4e
https://doi.org/10.1002/med.20044

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Trapping conformational states along ligand-binding dynamics of peptide deformylase: the impact of induced fit on enzyme catalysis

Autor: Sonia Fieulaine, Isabelle Artaud, Carmela Giglione, Michel Desmadril, Frédéric Dardel, Thierry Meinnel, Adrien Boularot

Publikováno v: PLoS Biology
PLoS Biology, 2011, 9 (5), pp.e1001066. ⟨10.1371/journal.pbio.1001066⟩
PLoS Biology, Vol 9, Iss 5, p e1001066 (2011)
PLoS Biology, Public Library of Science, 2011, 9 (5), pp.e1001066. ⟨10.1371/journal.pbio.1001066⟩
PLoS Biology, Public Library of Science, 2011, 9 (5), pp.e1001066. 〈10.1371/journal.pbio.1001066〉

For several decades, molecular recognition has been considered one of the most fundamental processes in biochemistry. For enzymes, substrate binding is often coupled to conformational changes that alter the local environment of the active site to ali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d34067933f835be1744736b33487c10
https://hal.science/hal-00851377

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The Crystal Structures of Four Peptide Deformylases Bound to the Antibiotic Actinonin Reveal Two Distinct Types: A Platform for the Structure-based Design of Antibacterial Agents

Autor: Patricia Gil, Jean-Pierre Guilloteau, Véronique Blanc, Alain Dupuy, Alain Famechon, Thierry Meinnel, Vincent Mikol, Miline Chevrier, Magali Mathieu, Carmela Giglione

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2002, 320 (5), pp.951-62. ⟨10.1016/S0022-2836(02)00549-1⟩

Bacterial peptide deformylase (PDF) belongs to a sub-family of metalloproteases that catalyse the removal of the N-terminal formyl group from newly synthesised proteins. PDF is essential in prokaryotes and conserved throughout the eubacteria. It is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44a5c8b5b851501fb31e2b22d970cb6
https://doi.org/10.1016/s0022-2836(02)00549-1

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Structure-activity relationship analysis of the peptide deformylase inhibitor 5-bromo-1H-indole-3-acetohydroxamic acid

Autor: Frédéric Dardel, Valéry Larue, Thierry Meinnel, Coralie Soulama, Carmela Giglione, Isabelle Artaud, Yann Duroc, Alexis Denis, Sylvain Petit, Carole Léon

Publikováno v: ChemMedChem
ChemMedChem, Wiley-VCH Verlag, 2009, 4 (2), pp.261-75. ⟨10.1002/cmdc.200800251⟩
ChemMedChem, Wiley-VCH Verlag, 2009, 4 (2), pp.261-75. 〈10.1002/cmdc.200800251〉
ChemMedChem, 2009, 4 (2), pp.261-75. ⟨10.1002/cmdc.200800251⟩

International audience; The lead compound 5-bromoindolyl-3-acetohydroxamic acid (10) was recently identified as a potent inhibitor of bacterial peptide deformylases (PDFs). The synthesis and associated activities of new variants were investigated at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25716bf8107887b01aed8aecb3581f0
https://hal.archives-ouvertes.fr/hal-00853803

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Bsr, a nuclear-retained RNA with monoallelic expression

Autor: Jérôme Cavaillé, Maud Marques, Eugenia Basyuk, Edouard Bertrand, Virginie Marty, Hélène Royo

Publikováno v: Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2007, 18 (8), pp.2817-27. 〈10.1091/mbc.E06-10-0920〉
Molecular Biology of the Cell, American Society for Cell Biology, 2007, 18 (8), pp.2817-27. ⟨10.1091/mbc.E06-10-0920⟩
Molecular Biology of the Cell, 2007, 18 (8), pp.2817-27. ⟨10.1091/mbc.E06-10-0920⟩

The imprinted Dlk1-Gtl2 and Prader-Willi syndrome (PWS) regions are characterized by a complex noncoding transcription unit spanning arrays of tandemly repeated C/D RNA genes. These noncoding RNAs (ncRNAs) are thought to play an essential but still p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2dee1c298a1e337acbbfb4acee9c956
https://hal.archives-ouvertes.fr/hal-00309029

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