Výsledky vyhledávání - "MESH : Hepatocytes"

Fate and PPARγ and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics

Autor: Thibaut Léger, Patrick Balaguer, Ludovic Le Hégarat, Valérie Fessard

Publikováno v: Journal of Hazardous Materials
Journal of Hazardous Materials, 2023, 442, pp.130083. ⟨10.1016/j.jhazmat.2022.130083⟩

Complete proteomic datasets are available in the PRIDE partner repository (Perez-Riverol et al., 2019) under identification numbers: PXD030822 and 10.6019/PXD030822 for HepaRG cells, PXD031045 and 10.6019/PXD031045 for HepaRG culture media, PXD030887

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94f6192bbc40d654e4abfe084531d7b
https://hal-anses.archives-ouvertes.fr/anses-03933720

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Functional compensation precedes recovery of tissue mass following acute liver injury

Autor: Ira Fleming, Carolyn Winston, Benjamin Kruft, Alex K. Shalek, Wolfram Goessling, Satdarshan P.S. Monga, Florian Mueller, Sungjin Ko, Udayan Apte, Chad Walesky, Kellie E. Kolb, Jake Henderson

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.5785. ⟨10.1038/s41467-020-19558-3⟩

The liver plays a central role in metabolism, protein synthesis and detoxification. It possesses unique regenerative capacity upon injury. While many factors regulating cellular proliferation during liver repair have been identified, the mechanisms b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b098b526816baaea3f6aa2942d407e5
https://doaj.org/article/19ae1c964a6645e69ee2804af9f1cfd1

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Hepatitis E virus replication in human intestinal cells

Autor: Sébastien Lhomme, Olivier Marion, Nicolas Carrere, Florence Abravanel, Marion Migueres, Nassim Kamar, Mélanie Pucelle, Pierre Delobel, Martine Dubois, Bertrand Suc, Mary Requena, Manon Nayrac, Jean-Marie Peron, Jacques Izopet

Publikováno v: Gut
Gut, BMJ Publishing Group, 2020, 69 (5), pp.901-910. ⟨10.1136/gutjnl-2019-319004⟩

ObjectiveHepatitis E virus (HEV), one of the most common agent of acute hepatitis worldwide, is mainly transmitted enterically, via contaminated water for HEV genotypes 1 (HEV1) and HEV2, or by eating raw or undercooked infected meat for HEV genotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56835005e2457dc7227b0e4cfe93e33f
https://pubmed.ncbi.nlm.nih.gov/31915238

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Vectorial Release of Hepatitis E Virus in Polarized Human Hepatocytes

Autor: Jacques Izopet, Olivier Marion, Sophie Allart, Sébastien Lhomme, Sabine Chapuy-Regaud, Justine Bertrand-Michel, Nicolas Capelli, Martine Dubois, Florence Abravanel

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2019, 93 (4), ⟨10.1128/JVI.01207-18⟩

International audience; Hepatitis E virus (HEV) is a common cause of acute viral hepatitis worldwide. Most HEV infections are asymptomatic, but immunocompromised patients infected with HEV genotype 3 (HEV3), HEV4, or HEV7 may develop chronic infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc46e65d9d7539bf8694a2a8b742c79
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03608725

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Instability of the NS1 Glycoprotein from La Reunion 2018 Dengue 2 Virus (Cosmopolitan-1 Genotype) in Huh7 Cells Is Due to Lysine Residues on Positions 272 and 324

Autor: Philippe Desprès, Olivier Diaz, Pierre-Olivier Vidalain, Vincent Lotteau, Eva Ogire, Marjolaine Roche

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (4), pp.1951. ⟨10.3390/ijms22041951⟩
International Journal of Molecular Sciences, Vol 22, Iss 1951, p 1951 (2021)
International Journal of Molecular Sciences, MDPI, 2021, 22 (4), pp.1951. ⟨10.3390/ijms22041951⟩
Volume 22
Issue 4

La Reunion island in the South West Indian Ocean is now endemic for dengue following the introduction of dengue virus serotype 2 (DENV-2) cosmopolitan-I genotype in 2017. DENV-2 infection causes a wide spectrum of clinical manifestations ranging from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ace2478b9e0813fd654ada099d78659
https://pubmed.ncbi.nlm.nih.gov/33669407

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Current knowledge on Hepatitis Delta Virus replication

Autor: Julie Lucifora, Marion Delphin

Publikováno v: Antiviral Research
Antiviral Research, Elsevier Masson, 2020, 179, pp.104812. ⟨10.1016/j.antiviral.2020.104812⟩

International audience; Hepatitis B Virus (HBV) that infects liver parenchymal cells is responsible for severe liver diseases and co-infection with Hepatitis Delta Virus (HDV) leads to the most aggressive form of viral hepatitis. Even tough being dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7137c3bbf90a5eea9a9cf903c15d2a7
https://hal.archives-ouvertes.fr/hal-03316035

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Retinoic Acid Inducible Gene I and Protein Kinase R, but Not Stress Granules, Mediate the Proinflammatory Response to Yellow Fever Virus

Autor: Maxime Chazal, Sarah Lesage, Takashi Fujita, Ségolène Gracias, Eliane F. Meurs, Laura Sinigaglia, Frédéric Tangy, Daniela Bruni, Felix Streicher, Guillaume Beauclair, Salomé Bourgeau, Nolwenn Jouvenet

Publikováno v: J Virol
Journal of Virology
Journal of Virology, 2020, 94 (22), pp.e00403-20. ⟨10.1128/JVI.00403-20⟩
Journal of Virology, American Society for Microbiology, 2020, 94 (22), pp.e00403-20. ⟨10.1128/JVI.00403-20⟩

International audience; Yellow fever virus (YFV) is an RNA virus primarily targeting the liver. Severe YF cases are responsible for hemorrhagic fever, plausibly precipitated by excessive proinflammatory cytokine response. Pathogen recognition recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658b3789c6d6a44b048370894bf30abf
https://pubmed.ncbi.nlm.nih.gov/32878892

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Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation

Autor: Ahmed Alshawi, Loranne Agius, Marc Foretz, Benoit Viollet, Silvia Marin, Natasha S. Adam-Primus, Shruti S. Chachra, Ziad H. Al-Oanzi, Tabassum Moonira, Marta Cascante, Catherine Arden, Brian E. Ford

Publikováno v: The Journal of Biological Chemistry
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (10), pp.3330-3346. ⟨10.1074/jbc.ra120.012533⟩

International audience; The chronic effects of metformin on liver gluconeogenesisinvolve repression of theG6pcgene, which is regulated by thecarbohydrate-response element–binding protein throughraised cellular intermediates of glucose metabolism. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f735b9110a996135298766fd5778907
https://pubmed.ncbi.nlm.nih.gov/31974165

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Fast Differentiation of HepaRG Cells Allowing Hepatitis B and Delta Virus Infections

Autor: Lucifora, Julie, Michelet, Maud, Salvetti, Anna, Durantel, David

Publikováno v: Cells
Cells, MDPI, 2020, 9 (10), pp.2288. ⟨10.3390/cells9102288⟩
Cells, Vol 9, Iss 2288, p 2288 (2020)
Cells, 2020, 9 (10), pp.2288. ⟨10.3390/cells9102288⟩

International audience; HepaRG cells are liver bipotent progenitors acquiring hepatocytes features when differentiated in the presence of dimethylsulfoxide (DMSO). Differentiated HepaRG (dHepaRG) are considered the best surrogate model to primary hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f4bc824c647a1f34305c15d93b989f81
https://hal.archives-ouvertes.fr/hal-03315941/document

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