IgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells

Autor: Stephen J. Galli, Martin L. Watzenboeck, Nicolas Gaudenzio, Thomas Marichal, Sylvia Knapp, Philipp Starkl, Frédéric Fontaine, Mindy Tsai, Riccardo Sibilano, Laurent L. Reber, André C. Mueller

Publikováno v: Allergy
Allergy, 2022, 77 (2), pp.499-512. ⟨10.1111/all.14852⟩

International audience; Background: In contrast to their clearly defined roles in allergic diseases, the physiologic functions of Immunoglobulin E antibodies (IgEs) and mast cells (MCs) remain enigmatic. Recent research supports the toxin hypothesis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1364330c2a92ede4bcc5ec0bcdfbc19
https://pubmed.ncbi.nlm.nih.gov/33840121

Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase

Autor: Emeline Richard, Véronique Roig-Zamboni, Hugues Lortat-Jacob, Firas Fadel, Jérôme Hénault, Adeline Goulet, Christine Le Narvor, Yves Bourne, David Bonnaffé, Vincent Delauzun, C. Debarnot, Yoan R. Monneau, Bernard Priem, Romain R. Vivès

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (14), pp.6760-6765. ⟨10.1073/pnas.1818333116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, pp.201818333. ⟨10.1073/pnas.1818333116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (14), pp.6760-6765. ⟨10.1073/pnas.1818333116⟩

Heparan sulfate (HS) is a linear, complex polysaccharide that modulates the biological activities of proteins through binding sites made by a series of Golgi-localized enzymes. Of these, glucuronyl C5-epimerase (Glce) catalyzes C5-epimerization of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f534dfa4e1c1196a83a65edeecbf515
https://hal-amu.archives-ouvertes.fr/hal-02339215/document

Fibrinolysis for patients with intermediate-risk pulmonary embolism

Autor: Sebastian Schellong, Mustapha Sebbane, Thierry Danays, Samuel Z. Goldhaber, Guy Meyer, Irene M. Lang, Cecilia Becattini, Eric Vicaut, Francis Couturaud, Christian Kupatt, Bożena Sobkowicz, Adam Torbicki, Claudia Dellas, Franck Verschuren, Erich Bluhmki, Hélène Bouvaist, Abstr Act, Nicolas Meneveau, Branislav Stefanovic, Benjamin Brenner, Annette Geibel, Piotr Pruszczyk, Mareike Lankeit, Jan Beyer-Westendorf, Ana Franca, Nils Kucher, Klaus Empen, David Jiménez, Matija Kozak, Nazzareno Galiè, Holger Thiele, Antoniu Petris, Giancarlo Agnelli, Gerard Pacouret, Aldo Salvi, Stavros Konstantinides, Matteo Rugolotto, Massimiliano Palazzini

Publikováno v: Meyer, Guy; Vicaut, Eric; Danays, Thierry; Agnelli, Giancarlo; Becattini, Cecilia; Beyer-Westendorf, Jan; Bluhmki, Erich; Bouvaist, Helene; Brenner, Benjamin; Couturaud, Francis; Dellas, Claudia; Empen, Klaus; Franca, Ana; Galiè, Nazzareno; Geibel, Annette; Goldhaber, Samuel Z.; Jimenez, David; Kozak, Matija; Kupatt, Christian; Kucher, Nils; ... (2014). Fibrinolysis for patients with intermediate-risk pulmonary embolism. New England journal of medicine NEJM, 370(15), pp. 1402-1411. Massachusetts Medical Society MMS 10.1056/NEJMoa1302097
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New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2014, 370 (15), pp.1402-11. 〈10.1056/NEJMoa1302097〉
New England Journal of Medicine, Massachusetts Medical Society, 2014, 370 (15), pp.1402-11. ⟨10.1056/NEJMoa1302097⟩

International audience; BACKGROUND: The role of fibrinolytic therapy in patients with intermediate-risk pulmonary embolism is controversial. METHODS: In a randomized, double-blind trial, we compared tenecteplase plus heparin with placebo plus heparin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8884407c666ea6ff838038ea707349a
https://pubmed.ncbi.nlm.nih.gov/25594091

Antithrombin-Independent Effects of Heparins on Fibrin Clot Nanostructure

Autor: Christelle Yeromonahos, Raphaël Marlu, Benoît Polack, François Caton

Publikováno v: Europe PubMed Central
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2012, 32 (5), pp.1320-4. ⟨10.1161/ATVBAHA.112.245308⟩
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2012, 32 (5), pp.1320-1324. ⟨10.1161/ATVBAHA.112.245308⟩

Objective— Because of the widespread clinical use of heparins, their effects on the enzymatic cascade are very well known. In contrast, little is known about the direct effect of heparins on the nanostructure of fibrin fibers, even though this nano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ecb86e08d213adb997823a28adebf3
https://doi.org/10.1161/atvbaha.112.245308

Mapping of the Fibroblast Growth Factors in Human White Adipose Tissue

Autor: Peter Arner, Jean Galitzky, Ingrid Dahlman, Niklas Mejhert, Mikael Rydén, Keith N. Frayn, Lennart Blomqvist, Amanda T. Pettersson, Clara Bambace, Anne Bouloumié

Publikováno v: Journal of Clinical Endocrinology and Metabolism
Journal of Clinical Endocrinology and Metabolism, 2010, 95 (5), pp.2451-7. ⟨10.1210/jc.2009-2049⟩
The Journal of Clinical Endocrinology & Metabolism; Vol 95
Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2010, 95 (5), pp.2451-7. ⟨10.1210/jc.2009-2049⟩

Context: Fibroblast growth factors (FGFs) regulate the development of white adipose tissue (WAT). However, the secretion and cellular origin of individual FGFs in WAT as well as the influence of obesity are unknown. Objective: Our objective was to ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62efdfb2c7490510d0eb1d78304e89f
https://doi.org/10.1210/jc.2009-2049