SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

Autor: Nancy Antoine, Lucie Ruiz, Holger Klein, Patrick Gilon, Anne Wojtusciszyn, Fiona M. Gribble, Frank Reimann, Robert Augustin, Bao-Khanh Lai, Bilal Singh, Michael P. Pieper, Eva Gatineau, Nano Rita, Mohammed Bensellam, Pedro Luis Herrera, Birgit Stierstorfer, Firas Khattab, Heeyoung Chae, Lorenzo Piemonti, Davide Brusa, Michael Mark, Eric Mayoux, Christophe Broca

Publikováno v: Molecular Metabolism
Molecular metabolism, vol. 42, pp. 101071
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 42, pp.101071. ⟨10.1016/j.molmet.2020.101071⟩
Molecular Metabolism (2020) P. 101071
Molecular Metabolism, Vol 42, Iss, Pp 101071-(2020)

Objective Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i), or gliflozins, are anti-diabetic drugs that lower glycemia by promoting glucosuria, but they also stimulate endogenous glucose and ketone body production. The likely causes of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13201cec4df0020051e57406d53b494a
https://pubmed.ncbi.nlm.nih.gov/32896668

Physiological and Pharmacological Mechanisms through which the DPP-4 Inhibitor Sitagliptin Regulates Glycemia in Mice

Autor: Pierre Cattan, Julien Castel, Rémy Burcelin, Aurélie Waget, Daniel J. Drucker, Mattieu Armanet, Melis Karaca, Christophe Magnan, Jens J. Holst, Céline Garret, Thierry Sulpice, Gaëlle Payros, Myriam Masseboeuf, Adriano Maida, Cendrine Cabou

Publikováno v: Endocrinology
Endocrinology, Endocrine Society, 2011, 152 (8), pp.3018-29. 〈10.1210/en.2011-0286〉
Endocrinology, 2011, 152 (8), pp.3018-29. ⟨10.1210/en.2011-0286⟩
Endocrinology, Endocrine Society, 2011, 152 (8), pp.3018-29. ⟨10.1210/en.2011-0286⟩

International audience; Inhibition of dipeptidyl peptidase-4 (DPP-4) activity improves glucose homeostasis through a mode of action related to the stabilization of the active forms of DPP-4-sensitive hormones such as the incretins that enhance glucos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f0300570214f5507362f1065f95366
https://doi.org/10.1210/en.2011-0286

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Autor: Kirk M. Habegger, Fa Liu, Dominik Lutter, Richard D. DiMarchi, Marc E. Healy, Maximilian Kleinert, Heike Biebermann, Yvonne Döring, Diego Perez-Tilve, Katrin Fischer, Luisa Müller, Peng Liu, Achim Weber, Susanna M. Hofmann, Christian Weber, Martin Jastroch, Frédéric Flamant, Miguel A. Sánchez-Garrido, Karl-Werner Schramm, Helmut Fuchs, Valerie Gailus-Durner, Brian Finan, Jan Rozman, Mohsen Malehmir, Sigrid Jall, Matthias H. Tschöp, Martin Hrabě de Angelis, Kerstin Stemmer, Josef Köhrle, Christoffer Clemmensen, Bin Yang, Meri De Angelis, Timo D. Müller, Sara J. Brandt, Zhimeng Zhu, Michaela Keuper, Vasily M. Gelfanov, Mathias Heikenwalder, Kristin Moreth, Frauke Neff, Jan Tuckermann, Karine Gauthier

Publikováno v: Cell
Cell, Elsevier, 2016, 167 (3), pp.843-857. ⟨10.1016/j.cell.2016.09.014⟩
Cell, Elsevier, 2016, 167 (3), pp.843-857.e14. ⟨10.1016/j.cell.2016.09.014⟩
Cell 167, 843-857.e14 (2016)
Cell, 167(3), 843-857. Cell Press
Cell, 2016, 167 (3), pp.843-857.e14. ⟨10.1016/j.cell.2016.09.014⟩

International audience; Glucagon and thyroid hormone (T3) exhibit therapeutic potential for metabolic disease but also exhibit undesired effects. We achieved synergistic effects of these two hormones and mitigation of their adverse effects by enginee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d42eda11b0af6ca1dd39246d570e3a
https://hal.archives-ouvertes.fr/hal-01607311

Sterol-regulatory-element-binding protein I c mediates insulin action on hepatic gene expression

Autor: Fabienne Foufelle, Pascal Ferré, Dominique Bécard, Marc Foretz, Dalila Azzout-Marniche

Publikováno v: Biochemical Society Transactions
Biochemical Society Transactions, 2001, 29 (4), pp.547-552. ⟨10.1042/bst0290547⟩
Biochemical Society Transactions, Portland Press, 2001, 29 (4), pp.547-552. ⟨10.1042/bst0290547⟩

Effects of insulin on the expression of liver-specific genes are part of the adaptive mechanisms aimed at maintaining energy homeostasis in mammals. When the diet is rich in carbohydrates, secreted insulin stimulates the expression of genes for enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5691deef1961f2983ca2fa2626ce036f
https://doi.org/10.1042/bst0290547

Sterol-regulatory-element-binding protein 1c mediates insulin action on hepatic gene expression

Autor: Ferré, P., Foretz, F, Azzout-Marniche, Dalila, Bécard, D, Foufelle, F.

Publikováno v: Biochemical Society Transactions
Biochemical Society Transactions, 2001, pp.547-52
Biochemical Society Transactions, Portland Press, 2001, pp.547-52

International audience; Effects of insulin on the expression of liver-specific genes are part of the adaptive mechanisms aimed at maintaining energy homeostasis in mammals. When the diet is rich in carbohydrates, secreted insulin stimulates the expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::840f409dbd505c84dfeeef52196dbc40
https://pubmed.ncbi.nlm.nih.gov/11498026